公开(公告)号：EP1190058A2

公开(公告)日：2002-03-27

申请号：EP98965500.6

申请日：1998-12-25

申请人： CHIRON CORPORATION ,  Hyseq Inc.

发明人： WILLIAMS, Lewis T. ,  ESCOBEDO, Jaime ,  INNIS, Michael A. ,  GARCIA, Pablo, Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  GIESE, Klaus ,  RANDAZZO, Filippo ,  KENNEDY, Giulia, C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA,Veronica ,  JONES, Lee, William ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1263956A2

公开(公告)日：2002-12-11

申请号：EP01918557.8

申请日：2001-03-09

申请人： Chiron Corporation ,  Hyseq Inc.

发明人： WILLIAMS, Lewis, T. ,  ESCOBEDO, Jaime ,  INNIS, Michael, A. ,  GARCIA, Pablo, Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  RANDAZZO, Filippo ,  KENNEDY, Giulia, C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C12N15/10 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/47

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1090117A2

公开(公告)日：2001-04-11

申请号：EP99930528.7

申请日：1999-06-22

申请人： CHIRON CORPORATION

发明人： KENNEDY, Giulia, C.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  C12N15/11 ,  C12N9/00

CPC分类号： C07K14/47

摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.

公开(公告)号：EP1370684A2

公开(公告)日：2003-12-17

申请号：EP01948414.6

申请日：2001-06-15

申请人： CHIRON CORPORATION

发明人： KENNEDY, Giulia, C. ,  KANG, Sanmao ,  REINHARD, Christoph ,  JEFFERSON, Anne, Bennet

IPC分类号： C12Q1/68 ,  C12N15/11 ,  A61K31/00 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： The present invention is based on the discovery of polynucleotides that represent genes that are differentially expressed in colon cancer, e.g., adenomatous polyp, colorectal carcinoma, high metastatic potential colon tumor and metastatic colon cancer. The invention features methods of identifying cells affected by such colon diseases by detection of a gene product encoded by such differentially expressed genes, as well as method of moduloating expression of such gene products to effect therapy (e.g., to decrease growth and/or affect abnormal characteristics of cancerous or displastic colon cells).