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公开(公告)号：EP1190058A2
公开(公告)日：2002-03-27
申请号：EP98965500.6
申请日：1998-12-25
申请人： CHIRON CORPORATION , Hyseq Inc.
发明人： WILLIAMS, Lewis T. , ESCOBEDO, Jaime , INNIS, Michael A. , GARCIA, Pablo, Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , GIESE, Klaus , RANDAZZO, Filippo , KENNEDY, Giulia, C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA,Veronica , JONES, Lee, William , STACHE-CRAIN, Birgit
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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公开(公告)号：EP1105474A2
公开(公告)日：2001-06-13
申请号：EP99925624.1
申请日：1999-05-13
申请人： Chiron Corporation , HYSEQ, INC.
发明人： WILLIAMS, Lewis, T , ESCOBEDO, Jaime , INNIS, Michael A. , GARCIA, Pablo Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , GIESE, Klaus , RANDAZZO, Filippo , KENNEDY, Giulia C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA, Veronica , JONES, Lee William , STACHE-CRAIN, Birgit
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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公开(公告)号：EP1309679A2
公开(公告)日：2003-05-14
申请号：EP01964160.4
申请日：2001-08-16
申请人： CHIRON CORPORATION , Hyseq Inc.
发明人： ESCOBEDO, Jaime , GARCIA, Pablo, Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , RANDAZZO, Filippo , LAMSON, George , SCOTT, Elizabeth, M. , ZHANG, Guozhong , KASSAM, Altaf , POT, David , LABAT, Ivan
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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公开(公告)号：EP1268528A2
公开(公告)日：2003-01-02
申请号：EP01962418.8
申请日：2001-03-27
申请人： Chiron Corporation , Hyseq Inc.
发明人： WILLIAMS, Lewis T. , ESCOBEDO, Jaime , INNIS, Michael A. , GARCIA, Pablo Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , HE, Zhijun , RANDAZZO, Filippo , KENNEDY, Giulia C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA, Veronica , JONES, Lee William , STACHE-CRAIN, Birgit
IPC分类号： C07K14/00
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variant thereof, to genes corresponding to theses polynucleotides and to proteins expressed by the genes. This invention also relates to diagnostic and therapeutic agents employing such novel polynucleotides, their corresponding genes or gene products, ∫i⊃e.g.∫/i⊃, these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。
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公开(公告)号：EP1263956A2
公开(公告)日：2002-12-11
申请号：EP01918557.8
申请日：2001-03-09
申请人： Chiron Corporation , Hyseq Inc.
发明人： WILLIAMS, Lewis, T. , ESCOBEDO, Jaime , INNIS, Michael, A. , GARCIA, Pablo, Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , RANDAZZO, Filippo , KENNEDY, Giulia, C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA, Veronica , STACHE-CRAIN, Birgit
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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6.发明公开SIGNALING INOSITOL POLYPHOSPHATE 5-PHOSPHATASES (SIPs) 失效非甾体类聚磷酸酯-5-磷酸酯（SIPs）FUER DIE SIGNALUEBERTRAGUNG
公开(公告)号：EP0865483A2
公开(公告)日：1998-09-23
申请号：EP96942928.0
申请日：1996-12-06
申请人： CHIRON CORPORATION
摘要： Novel polypeptides called signaling inositol polyphosphate 5-phosphatases are described called SIP-130, SIP-125, and SIP-N. SIP-130 is capable of binding to a PTB domain of SH2 and collagen containing protein (SHC). Also provided are polynucleotide sequences encoding the novel polypeptides, as well as vectors and host cells containing the polynucleotides. Further provided are modulators including agonists and antagonists of the novel polypeptides for use as therapeutics, including antibodies, polypeptides, small molecules, and polynucleotides and methods of using the therapeutics in treatment of diseases associated with abnormal cell growth. Methods of making the polypeptides, polynucleotides, vectors, host cells, antibodies, and small molecules are also provided. Gene delivery vehicles including SIP and SIP activity-modulating polynucleotides are described.
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