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公开(公告)号：EP1190058A2
公开(公告)日：2002-03-27
申请号：EP98965500.6
申请日：1998-12-25
申请人： CHIRON CORPORATION , Hyseq Inc.
发明人： WILLIAMS, Lewis T. , ESCOBEDO, Jaime , INNIS, Michael A. , GARCIA, Pablo, Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , GIESE, Klaus , RANDAZZO, Filippo , KENNEDY, Giulia, C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA,Veronica , JONES, Lee, William , STACHE-CRAIN, Birgit
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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公开(公告)号：EP1105474A2
公开(公告)日：2001-06-13
申请号：EP99925624.1
申请日：1999-05-13
申请人： Chiron Corporation , HYSEQ, INC.
发明人： WILLIAMS, Lewis, T , ESCOBEDO, Jaime , INNIS, Michael A. , GARCIA, Pablo Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , GIESE, Klaus , RANDAZZO, Filippo , KENNEDY, Giulia C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA, Veronica , JONES, Lee William , STACHE-CRAIN, Birgit
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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公开(公告)号：EP1263956A2
公开(公告)日：2002-12-11
申请号：EP01918557.8
申请日：2001-03-09
申请人： Chiron Corporation , Hyseq Inc.
发明人： WILLIAMS, Lewis, T. , ESCOBEDO, Jaime , INNIS, Michael, A. , GARCIA, Pablo, Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , RANDAZZO, Filippo , KENNEDY, Giulia, C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA, Veronica , STACHE-CRAIN, Birgit
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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公开(公告)号：EP1309679A2
公开(公告)日：2003-05-14
申请号：EP01964160.4
申请日：2001-08-16
申请人： CHIRON CORPORATION , Hyseq Inc.
发明人： ESCOBEDO, Jaime , GARCIA, Pablo, Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , RANDAZZO, Filippo , LAMSON, George , SCOTT, Elizabeth, M. , ZHANG, Guozhong , KASSAM, Altaf , POT, David , LABAT, Ivan
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
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公开(公告)号：EP1268528A2
公开(公告)日：2003-01-02
申请号：EP01962418.8
申请日：2001-03-27
申请人： Chiron Corporation , Hyseq Inc.
发明人： WILLIAMS, Lewis T. , ESCOBEDO, Jaime , INNIS, Michael A. , GARCIA, Pablo Dominguez , SUDDUTH-KLINGER, Julie , REINHARD, Christoph , HE, Zhijun , RANDAZZO, Filippo , KENNEDY, Giulia C. , POT, David , KASSAM, Altaf , LAMSON, George , DRMANAC, Radoje , CRKVENJAKOV, Radomir , DICKSON, Mark , DRMANAC, Snezana , LABAT, Ivan , LESHKOWITZ, Dena , KITA, David , GARCIA, Veronica , JONES, Lee William , STACHE-CRAIN, Birgit
IPC分类号： C07K14/00
CPC分类号： C07K14/47
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variant thereof, to genes corresponding to theses polynucleotides and to proteins expressed by the genes. This invention also relates to diagnostic and therapeutic agents employing such novel polynucleotides, their corresponding genes or gene products, ∫i⊃e.g.∫/i⊃, these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。
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6.发明公开ANTISENSE THERAPY USING OLIGONUCLEOTIDES THAT TARGET HUMAN KINESIN GENES FOR TREATMENT OF CANCER 审中-公开反义治疗使用的寡核苷酸靶向人KINESINGENE是癌症的治疗
公开(公告)号：EP1451205A2
公开(公告)日：2004-09-01
申请号：EP02776213.7
申请日：2002-10-11
申请人： CHIRON CORPORATION
CPC分类号： C12N15/113 , A61K31/7088 , A61K38/00 , A61K45/06 , C12N15/1137 , A61K2300/00
摘要： The present invention is directed toward the use of antisense oligonucleotides that target human kinesin genes for treating diseases involving aberrant cell proliferation, particularly cancers such as colon cancer. Also, the invention is directed to a synergistic combination for treating cancer comprising a chemotherapeutic such as cisplatin and an antisense oligonucleotide that specifically inhibits human kinesin expression.
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公开(公告)号：EP1480995A2
公开(公告)日：2004-12-01
申请号：EP03711050.9
申请日：2003-02-12
申请人： CHIRON CORPORATION
CPC分类号： C12N15/113 , A61K38/00
摘要： Inhibitors of human Cks1 and human Skp2, including antisense oligonucleotides, methods, and compositions specific for human Cks1 and human Skp2, are provided. Methods of using the compositions for modulating Cks1 expression and Skp2 expression, and for regulating cell growth, particularly tumor cell growth, are also provided.
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公开(公告)号：EP1141331A2
公开(公告)日：2001-10-10
申请号：EP99967389.0
申请日：1999-12-16
申请人： CHIRON CORPORATION
发明人： REINHARD, Christoph
CPC分类号： C12N9/1205 , C07K2319/00
摘要： A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.
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9.发明公开METHODS OF MODULATING METASTASIS AND SKELETAL RELATED EVENTS RESULTING FROM METASTASES 审中-公开方法调制转移的关系，并与转移的基骨架相关事件
公开(公告)号：EP1628992A2
公开(公告)日：2006-03-01
申请号：EP04751974.9
申请日：2004-05-12
申请人： CHIRON CORPORATION
CPC分类号： A61K31/663 , A61K31/7088 , A61K45/06 , A61K2300/00
摘要： The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.
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10.发明公开COMPOSITIONS COMPRISING NET-4 MODULATORS AND THEIR USE FOR TREATING NEOPLASTIC DISEASE 审中-公开组合物NET-4调节剂遏制和它们用于癌症治疗
公开(公告)号：EP1290029A2
公开(公告)日：2003-03-12
申请号：EP01942047.0
申请日：2001-06-05
申请人： CHIRON CORPORATION
IPC分类号： C07K14/705 , C12N15/11 , A61K48/00 , A61P35/00 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C07K14/715 , C12Q1/6886 , C12Q2600/158
摘要： Modulators of NET-4 are provided that reduce the expression or biological activities of NET-4 or the expression of NET-4mRNA in a mammalian cell. NET-4 modulators include antisense molecules, NET-4 modulators find use in compositions and methods for decreasing NET-4 gene expression as well as methods for inhibiting the proliferation of mammalian cells, including tumor cells, and methods for treating neoplastic diseases.
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