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公开(公告)号：EP2663646B1
公开(公告)日：2018-09-12
申请号：EP12734376.2
申请日：2012-01-16
发明人： KIM, So Young , SHIN, Yong Uk , HEO, In Kyung , KIM, Ju Eun , SON, Sung Kwang , SEO, Chang Il , KIM, Hyun Ah , LEE, Han Jin , NA, Kwang Ho , BAE, Jee Yeon
IPC分类号： C12P17/12 , C07D213/80
CPC分类号： C12P17/12 , C07D213/80
摘要： A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.
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2.发明公开MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM 审中-公开微生物，O-乙酰高丝氨酸制定和方法产生O-乙酰高丝氨酸微生物法
公开(公告)号：EP3042950A1
公开(公告)日：2016-07-13
申请号：EP16156542.9
申请日：2010-03-11
发明人： KIM, So Young , SHIN, Yonk Uk , HEO, In Kyung , KIM, Hyun Ah , SEO, Chang Il , KIM, Ju Eun , SON, Sung Kwang , LEE, Sang Mok , JHON, Sung Hoo , LEE, Han Jin , NA, Kwang Ho
CPC分类号： C12N9/1217 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12P13/06
摘要： Disclosed is a strain of Escherichia sp., capable of producing 0-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing 0-acetyl homoserine using the strain is provided.
摘要翻译： 。本发明公开了埃希氏菌属的菌株，能够以高产量产生O-乙酰高丝氨酸的，具有在其中的活性的引入和增强：高丝氨酸乙酰转移酶，天冬氨酸激酶和高丝氨酸脱氢酶; 和至少一种酶由选自由磷酸烯醇丙酮酸羧，天冬氨酸氨基转移酶和天冬氨酸半醛脱氢酶组成的组。 所以，提供了一种生产使用菌株0乙酰高丝氨酸的方法。
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3.发明公开NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME 有权新的O-乙酰丝氨酸硫化氢或版本体和方法使其转化蛋氨酸SO
公开(公告)号：EP2657249A2
公开(公告)日：2013-10-30
申请号：EP11850058.6
申请日：2011-12-21
发明人： KIM, So Young , SHIN, Yong Uk , SEO, Chang Il , SON, Sung Kwang , HEO, In Kyung , LEE, Han Jin , KIM, Ju Eun , KIM, Hyun Ah , BAE, Jee Yeon , NA, Kwang Ho
IPC分类号： C07K14/195 , C12N15/31 , C12N15/60 , C12N15/70
CPC分类号： C12N9/1085 , C12P7/54 , C12P13/12 , C12Y205/01049
摘要： The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield.
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4.发明授权NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME 有权新的O-乙酰丝氨酸硫化氢或版本体和方法使其转化蛋氨酸SO
公开(公告)号：EP2657249B1
公开(公告)日：2017-03-15
申请号：EP11850058.6
申请日：2011-12-21
发明人： KIM, So Young , SHIN, Yong Uk , SEO, Chang Il , SON, Sung Kwang , HEO, In Kyung , LEE, Han Jin , KIM, Ju Eun , KIM, Hyun Ah , BAE, Jee Yeon , NA, Kwang Ho
CPC分类号： C12N9/1085 , C12P7/54 , C12P13/12 , C12Y205/01049
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5.发明公开VARIANT POLYPEPTIDE HAVING HOMOSERINE ACETYLTRANSFERASE ACTIVITY AND MICROORGANISM EXPRESSING SAME 有权变种多糖多肽微量元素 - 乙酰胆碱酯酶维生素
公开(公告)号：EP2657250A2
公开(公告)日：2013-10-30
申请号：EP11852010.5
申请日：2011-12-21
发明人： KIM, So Young , SHIN, Yong Uk , SEO, Chang Il , HEO, In Kyung , KIM, Ju Eun , KIM, Hyun Ah , LEE, Han Jin , NA, Kwang Ho , SON, Sung Kwang
IPC分类号： C07K14/245 , C12N15/54 , C12N15/70 , C12P13/06 , C12R1/19
CPC分类号： C12N9/1029 , C12N1/00 , C12N15/70 , C12N15/74 , C12P13/06 , C12Y203/01031
摘要： The present invention relates to a polypeptide that is modified to have homoserine O-acetyltransferase activity, and in particular, the present invention provides a modified polypeptide having homoserine O-acetyltransferase activity, in which the amino acid at position 111 of a polypeptide having homoserine succinyltransferase activity is substituted with other amino acid.
摘要翻译： 本发明涉及被修饰为具有高丝氨酸O-乙酰转移酶活性的多肽，特别是本发明提供了具有高丝氨酸O-乙酰转移酶活性的修饰多肽，其中具有高丝氨酸琥珀酰转移酶的多肽的111位氨基酸 活性被其他氨基酸取代。
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6.发明公开MICROORGANISM PRODUCING L-METHIONINE PRECURSOR AND THE METHOD OF PRODUCING L-METHIONINE PRECURSOR USING THE MICROORGANISM 审中-公开微生物生产L-蛋氨酸前体及其制备方法L-蛋氨酸前体微生物
公开(公告)号：EP3081649A1
公开(公告)日：2016-10-19
申请号：EP16165937.0
申请日：2009-04-03
发明人： SHIN, Young Uk , KIM, So Young , CHANG, Jin Sook , CHO, Young Wook , LEE, Han Jin , HEO, In Kyung , NA, Kwang Ho , SEO, Chang Il , KIM, Chul Ha , UM, Hye Won
CPC分类号： C12P13/06 , C12N9/1029
摘要： The present invention relates to a microorganism producing L-methionine precursor, O-succinylhomoserine, and a method of producing L-methionine precursor using the microorganism.
摘要翻译： 本发明涉及一种微生物生产L-甲硫氨酸前体，O-琥珀酰高，和使用该微生物生产L-甲硫氨酸前体的方法。
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公开(公告)号：EP2663646A2
公开(公告)日：2013-11-20
申请号：EP12734376.2
申请日：2012-01-16
发明人： KIM, So Young , SHIN, Yong Uk , HEO, In Kyung , KIM, Ju Eun , SON, Sung Kwang , SEO, Chang Il , KIM, Hyun Ah , LEE, Han Jin , NA, Kwang Ho , BAE, Jee Yeon
CPC分类号： C12P17/12 , C07D213/80
摘要： The present invention relates to a method for the preparation of nicotinic acid, which comprises the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.
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8.发明公开METHOD FOR INCREASING METHIONINE PRODUCTIVITY USING A MIXTURE OF METHYL MERCAPTAN AND DIMETHYL SULFIDE 有权METHOD FOR USING增甲硫醇和二甲的混合物METHIONINPRODUKTIVITÄT
公开(公告)号：EP2402453A2
公开(公告)日：2012-01-04
申请号：EP10746468.7
申请日：2010-02-26
发明人： KIM, So Young , SHIN, Yong Uk , HEO, In Kyung , KIM, Hyun Ah , KIM, Ju Eun , SEO, Chang Il , SON, Sung Kwang , LEE, Sang Mok , JHON, Sung Hoo , LEE, Han Jin , NA, Kwang Ho , KIM, Il Chul
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention relates to a method for increasing L-methionine productivity and organic acid productivity. More particularly, the present invention relates to a method which involves adding a mixture containing methyl mercaptan and dimethyl sulfide at a appropriate appropriateratioto O-acetyl homoserine or O-succinyl homoserine and to an enzyme having an activity of converting methionine precursor into L-methionine, so as to perform an enzyme reaction, to thereby improve the conversion rate of L-methionine and organic acid from the L-methionine precursor, and thus increasing L-methionine yield as compared to conventional method..
摘要翻译： 本发明涉及用于增加L-蛋氨酸生产效率和有机酸生产率的方法。 更具体地，本发明涉及一种方法，其涉及在一适当appropriateratioto O-乙酰高丝氨酸或O-琥珀酰高丝氨酸和在酶具有甲硫氨酸前体转化为L-蛋氨酸的活性将含有甲硫醇和二甲硫醚的混合物， 速率，以便在酶反应进行，从而提高L-甲硫氨酸和有机酸从L-甲硫氨酸前体的转化率，并因此增加了L-甲硫氨酸的产量相比于常规方法..
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9.发明公开
公开(公告)号：EP4332229A1
公开(公告)日：2024-03-06
申请号：EP21939436.8
申请日：2021-05-25
发明人： LEE, Young Ju , LEE, Sun Hee , LEE, Han Jin , PARK, Seok Hyun , PARK, Joon Hyun
摘要： Provided are a Corynebacterium glutamicum variant with improved L-lysine producing ability and a method of producing L-lysine using the same. The variant increases or enhances the expression of a gene encoding aspartate aminotransferase, thereby improving a production yield of L-lysine, as compared to a parent strain.
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公开(公告)号：EP3081649B1
公开(公告)日：2019-06-05
申请号：EP16165937.0
申请日：2009-04-03
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