公开(公告)号：EP3303267A2

公开(公告)日：2018-04-11

申请号：EP16800751.6

申请日：2016-05-26

申请人： California Institute of Technology ,  Provivi, Inc.

发明人： ARNOLD, Frances H. ,  RENATA, Hans ,  MCINTOSH, John A. ,  LEWIS, Russell D. ,  KAN, Sek Bik Jennifer ,  HERNANDEZ, Kari ,  COELHO, Pedro ,  ROZZELL, David ,  ZHANG, Chen

IPC分类号： C07C2/52 ,  C07K14/795 ,  C07K14/80 ,  C07K14/805 ,  C12N15/31 ,  C12P1/04

CPC分类号： C12P7/62 ,  C07C49/697 ,  C12N9/0071 ,  C12P7/26 ,  C12Y106/02004 ,  C12Y114/14001 ,  C12Y114/15003

摘要： The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

公开(公告)号：EP3376859A1

公开(公告)日：2018-09-26

申请号：EP16867255.8

申请日：2016-11-18

申请人： Provivi, Inc.

发明人： LEONARD, Effendi ,  MEINHOLD, Peter ,  WAMPLER, Keith ,  COELHO, Pedro ,  SHEPPARD, Micah ,  HEEL, Thomas

IPC分类号： A01M29/12 ,  A01N37/46 ,  A61K9/42 ,  C07C57/66 ,  C12N15/53 ,  C12N15/63 ,  C12P7/64

CPC分类号： A01N63/02 ,  C12P7/6436 ,  C12P7/6472

摘要： The present application relates to recombinant microorganisms useful in the biosynthesis of unsaturated C6-C24 fatty alcohols, aldehydes, and acetates which may be useful as insect pheromones, fragrances, flavors, and polymer intermediates. The C6-C24 fatty alcohols, aldehydes, and acetates described herein may be used as substrates for metathesis reactions to expand the repertoire of target compounds and pheromones. The application further relates to recombinant microorganisms co-expressing a pheromone pathway and a pathway for the production of a toxic protein, peptide, oligonucleotide, or small molecule suitable for use in an attract-and-kill pest control approach. Also provided are methods of producing unsaturated C6-C24 fatty alcohols, aldehydes, and acetates using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product alcohols, aldehydes, or acetates.

公开(公告)号：EP4234522A2

公开(公告)日：2023-08-30

申请号：EP23178988.4

申请日：2016-11-17

申请人： Provivi, Inc.

发明人： MEHDI, Hasan ,  WAMPLER, Keith M. ,  MEINHOLD, Peter ,  COELHO, Pedro ,  BUI, Vu

IPC分类号： C07C6/02 ,  C07C6/04 ,  B01J31/22 ,  C07C29/147 ,  C07C67/08 ,  C07C67/293 ,  C07C67/343 ,  C07C45/41

摘要： The invention provides a method for synthesizing a fatty olefin derivative. In some embodiments, the method includes: a) contacting an unsaturated olefin with an unsaturated fatty acid ester in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product and b) converting the metathesis product to the fatty olefin derivative. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is an insect pheromone. Pheromone compositions and methods of using them are also described.

公开(公告)号：EP4234522A3

公开(公告)日：2023-10-25

申请号：EP23178988.4

申请日：2016-11-17

申请人： Provivi, Inc.

发明人： MEHDI, Hasan ,  WAMPLER, Keith M. ,  MEINHOLD, Peter ,  COELHO, Pedro ,  BUI, Vu

IPC分类号： C07C6/02 ,  C07C6/04 ,  B01J31/22 ,  C07C29/147 ,  C07C67/08 ,  C07C67/293 ,  C07C67/343 ,  C07C45/41

摘要： The invention provides a method for synthesizing a fatty olefin derivative. In some embodiments, the method includes: a) contacting an unsaturated olefin with an unsaturated fatty acid ester in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product and b) converting the metathesis product to the fatty olefin derivative. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is an insect pheromone. Pheromone compositions and methods of using them are also described.

公开(公告)号：EP3583088A2

公开(公告)日：2019-12-25

申请号：EP18753853.3

申请日：2018-02-17

申请人： Provivi, Inc.

发明人： WAMPLER, Keith M. ,  BUI, Vu ,  ROZZELL, David ,  COELHO, Pedro ,  FLORUTI, Arthur ,  ONDI, Levente ,  MEHDI, Hasan ,  EROS, Gabor

IPC分类号： C07C29/00

公开(公告)号：EP3377465A2

公开(公告)日：2018-09-26

申请号：EP16867164.2

申请日：2016-11-17

申请人： Provivi, Inc.

发明人： ONDI, Levente ,  MEHDI, Hasan ,  WAMPLER, Keith M. ,  MEINHOLD, Peter ,  COELHO, Pedro ,  BUI, Vu

IPC分类号： C07C6/02 ,  C07C6/04

CPC分类号： B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07B2200/09 ,  C07C6/04 ,  C07C29/147 ,  C07C45/41 ,  C07C67/08 ,  C07C67/293 ,  C07C67/343 ,  C07C2531/22 ,  C07C69/533 ,  C07C33/025 ,  C07C69/145 ,  C07C47/21 ,  C07C11/21

摘要： and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

公开(公告)号：EP3868890A1

公开(公告)日：2021-08-25

申请号：EP20216824.1

申请日：2016-11-18

申请人： Provivi, Inc.

发明人： LEONARD, Effendi ,  MEINHOLD, Peter ,  WAMPLER, Keith ,  COELHO, Pedro ,  SHEPPARD, Micah ,  HEEL, Thomas

IPC分类号： C12P7/64 ,  C12N9/02 ,  C12N15/52 ,  C12N15/53 ,  C12N15/63 ,  C07C57/66 ,  A61K9/42 ,  A01M29/12 ,  A01N37/46 ,  A01N63/50

摘要： The present application relates to recombinant microorganisms useful in the biosynthesis of unsaturated C 6 -C 24 fatty alcohols, aldehydes, and acetates which may be useful as insect pheromones, fragrances, flavors, and polymer intermediates. The C 6 -C 24 fatty alcohols, aldehydes, and acetates described herein may be used as substrates for metathesis reactions to expand the repertoire of target compounds and pheromones. The application further relates to recombinant microorganisms co-expressing a pheromone pathway and a pathway for the production of a toxic protein, peptide, oligonucleotide, or small molecule suitable for use in an attract-and-kill pest control approach. Also provided are methods of producing unsaturated C 6 -C 24 fatty alcohols, aldehydes, and acetates using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product alcohols, aldehydes, or acetates.

公开(公告)号：EP3635124A1

公开(公告)日：2020-04-15

申请号：EP18803040.7

申请日：2018-05-17

申请人： Provivi, Inc.

发明人： SHEPPARD, Micah ,  HEEL, Thomas ,  MEINHOLD, Peter ,  WAMPLER, Keith ,  COELHO, Pedro ,  LEONARD, Effendi

IPC分类号： C12P7/04 ,  C12P7/24 ,  C12P7/64 ,  C12N9/02 ,  C12N9/10