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公开(公告)号：EP2945621A1
公开(公告)日：2015-11-25
申请号：EP14703010.0
申请日：2014-01-17
发明人： KALISH, Vincent Jacob , REARDON, John , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie , TOSCANO, John P.
IPC分类号： A61K31/18 , C07D307/64 , A61P9/04 , C07C317/14
CPC分类号： A61K31/341 , A61K9/0019 , A61K9/08 , A61K31/18 , A61K31/222 , A61K31/24 , A61K31/255 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/42 , A61K31/433 , A61K31/4436 , A61K31/5377 , A61K31/538 , A61K47/12 , A61K47/40 , C07C317/14 , C07D307/64
摘要： The disclosed subject matter provides N- substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
摘要翻译： 所公开的主题提供了N-取代的羟胺衍生物化合物，药物组合物和包含这些化合物的试剂盒，以及使用这些化合物或药物组合物的方法。 特别地，所公开的主题提供了使用这些化合物或药物组合物治疗心力衰竭的方法。
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2.发明公开
公开(公告)号：EP2509941A2
公开(公告)日：2012-10-17
申请号：EP10793381.4
申请日：2010-12-07
发明人： TOSCANO, John P. , SUTTON, Art , KALISH, Vincent J. , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie
IPC分类号： C07C311/48 , A61K31/18 , A61P9/04 , C07D265/00 , C07C317/14
CPC分类号： C07C311/48 , C07C311/51 , C07C317/14 , C07C317/32 , C07C2601/14 , C07D207/06 , C07D207/16 , C07D209/48 , C07D211/46 , C07D211/58 , C07D211/62 , C07D213/40 , C07D213/46 , C07D213/59 , C07D213/71 , C07D213/74 , C07D233/38 , C07D241/04 , C07D241/08 , C07D295/192 , C07D295/195 , C07D295/205 , C07D307/82 , C07D309/12 , C07D317/30 , C07D333/34 , C07D401/04 , C07D413/04
摘要： The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
摘要翻译： 本发明提供某些N-酰氧基磺酰胺和N-羟基-N-酰基磺酰胺衍生物化合物，包含这些化合物的药物组合物和试剂盒，以及使用这些化合物或药物组合物的方法。 特别地，本发明提供了使用这些化合物或药物组合物治疗，预防或延缓疾病或病症发作和/或发展的方法。 在一些实施方案中，疾病或病症选自心血管疾病，局部缺血，再灌注损伤，癌性疾病，肺动脉高压和对硝酰基治疗有反应的病症。
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公开(公告)号：EP3427728A1
公开(公告)日：2019-01-16
申请号：EP18190818.7
申请日：2014-01-17
发明人： KALISH, Vincent Jacob , REARDON, John , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie , TOSCANO, John P.
IPC分类号： A61K31/18 , C07D307/64 , A61P9/04 , C07C317/14
摘要： The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N -substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases ( e.g ., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.
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公开(公告)号：EP2945621B1
公开(公告)日：2018-10-17
申请号：EP14703010.0
申请日：2014-01-17
发明人： KALISH, Vincent Jacob , REARDON, John , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie , TOSCANO, John P.
IPC分类号： A61K31/18 , C07D307/64 , A61P9/04 , C07C317/14
CPC分类号： A61K31/341 , A61K9/0019 , A61K9/08 , A61K31/18 , A61K31/222 , A61K31/24 , A61K31/255 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/42 , A61K31/433 , A61K31/4436 , A61K31/5377 , A61K31/538 , A61K47/12 , A61K47/40 , C07C317/14 , C07D307/64
摘要： The disclosed subject matter provides N- substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
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公开(公告)号：EP2509942A2
公开(公告)日：2012-10-17
申请号：EP10795136.0
申请日：2010-12-07
发明人： TOSCANO, John P. , SUTTON, Art , KALISH, Vincent J. , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie
IPC分类号： C07C311/48 , C07C233/92 , C07C233/66 , A61K31/67 , A61K31/18 , A61P9/04
CPC分类号： C07D333/34 , C07C233/01 , C07C233/64 , C07C259/06 , C07C259/10 , C07C271/08 , C07C311/51 , C07C311/53 , C07C317/14 , C07C317/28 , C07C317/32 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D213/40 , C07D213/71 , C07D295/205 , C07D295/215 , C07D307/82 , C07D309/12
摘要： The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
摘要翻译： 本发明提供某些双酰化羟胺衍生物化合物，包含这些化合物的药物组合物和试剂盒，以及使用这些化合物或药物组合物的方法。 特别地，本发明提供了使用这些化合物或药物组合物治疗，预防或延缓疾病或病症发作和/或发展的方法。 在一些实施方案中，疾病或病症选自心血管疾病，局部缺血，再灌注损伤，癌性疾病，肺动脉高压和对硝酰基治疗有反应的病症。
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公开(公告)号：EP3148972B1
公开(公告)日：2019-08-21
申请号：EP15726852.5
申请日：2015-05-26
发明人： KALISH, Vincent Jacob , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie , TOSCANO, John P. , GUTHRIE, Daryl A. , NORTH, Carl Leslie
IPC分类号： C07D231/46 , C07D231/56 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D491/044 , C07D491/048 , C07D491/052 , A61K31/4152 , A61P9/00
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公开(公告)号：EP2509941B1
公开(公告)日：2019-01-23
申请号：EP10793381.4
申请日：2010-12-07
发明人： TOSCANO, John P. , SUTTON, Art , KALISH, Vincent J. , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie
IPC分类号： C07C311/48 , A61K31/18 , A61P9/04 , C07D265/00 , C07C317/14
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公开(公告)号：EP3365325A1
公开(公告)日：2018-08-29
申请号：EP16790490.3
申请日：2016-10-18
发明人： KALISH, Vincent Jacob , FROST, Lisa, Marie , BROOKFIELD, Frederick Arthur , TOSCANO, John P. , COURTNEY, Stephen, Martin
IPC分类号： C07C311/00 , C07D213/71 , C07D309/10 , C07D317/40 , C07D317/54 , C07D231/12 , C07D333/34 , C07D405/12 , C07D413/12 , C07D241/24 , C07D261/08 , C07D271/12 , C07D295/26 , C07D213/30 , C07D307/52
CPC分类号： C07C311/48 , A61P9/00 , C07C317/14 , C07C2601/08 , C07D213/30 , C07D213/71 , C07D231/12 , C07D241/24 , C07D261/08 , C07D271/12 , C07D295/26 , C07D307/52 , C07D307/82 , C07D309/10 , C07D317/40 , C07D317/54 , C07D333/34 , C07D405/12 , C07D413/12
摘要： The disclosed subject matter provides N- hydroxylsulfonamide derivative compounds of formulae (I), (II) or (III) as drawn below, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
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公开(公告)号：EP3148972A1
公开(公告)日：2017-04-05
申请号：EP15726852.5
申请日：2015-05-26
发明人： KALISH, Vincent J. , BROOKFIELD, Frederick A. , COURTNEY, Stephen M. , FROST, Lisa M. , TOSCANO, John P. , GUTHRIE, Daryl A. , NORTH, Carl L.
IPC分类号： C07D231/46 , C07D231/56 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D491/044 , C07D491/048 , C07D491/052 , A61K31/4152 , A61P9/00
CPC分类号： C07D231/46 , C07D231/56 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
摘要翻译： 所公开的主题提供吡唑啉酮衍生物化合物，包含此类化合物的药物组合物，包含此类化合物的试剂盒以及使用此类化合物或药物组合物的方法。 具体而言，所公开的主题提供了使用这种化合物或药物组合物治疗心力衰竭的方法。
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