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公开(公告)号:EP3620534A1
公开(公告)日:2020-03-11
申请号:EP19188624.1
申请日:2014-03-12
发明人: MAY, Andrew, Paul , HAURWITZ, Rachel, E. , DOUDNA, Jennifer, A. , BERGER, James, M. , CARTER, Matthew, Merrill , DONOHOUE, Paul
IPC分类号: C12Q1/6818 , C12Q1/6806 , C12Q1/6869 , C12N9/22 , C12N15/113 , C12N15/52 , C12N15/10
摘要: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.
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公开(公告)号:EP2971167A1
公开(公告)日:2016-01-20
申请号:EP14771135.2
申请日:2014-03-12
发明人: MAY, Andrew, Paul , HAURWITZ, Rachel, E. , DOUDNA, Jennifer, A. , BERGER, James, M. , CARTER, Matthew, Merrill , DONOHOUE, Paul
IPC分类号: C12Q1/68
CPC分类号: C12N15/11 , A61K38/465 , A61K47/549 , A61K47/6455 , C12N9/22 , C12N15/102 , C12N15/113 , C12N15/52 , C12N15/85 , C12N15/90 , C12N15/902 , C12N15/907 , C12N2310/20 , C12N2310/531 , C12N2310/533 , C12N2800/80 , C12Q1/68 , C12Q1/6806 , C12Q1/6818 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q2525/203
摘要: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer to altering the genome by deleting, inserting, mutating, or substituting specific nucleic acid sequences. The altering can be gene or location specific. Genome engineering can use nucleases to cut a nucleic acid thereby generating a site for the alteration. Engineering of non-genomic nucleic acid is also contemplated.
摘要翻译: 本公开提供了用于使用核酸靶向核酸及其复合物的组合物和方法。 基因组工程可以指通过删除,插入,突变或取代特定的核酸序列来改变基因组。 改变可以是基因或特定位置。 基因组工程可以使用核酸酶来切割核酸,从而产生改变的位点。 还设想了非基因组核酸的工程。
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公开(公告)号:EP2971167B1
公开(公告)日:2019-07-31
申请号:EP14771135.2
申请日:2014-03-12
发明人: MAY, Andrew, Paul , HAURWITZ, Rachel, E. , DOUDNA, Jennifer, A. , BERGER, James, M. , CARTER, Matthew, Merrill , DONOHOUE, Paul
IPC分类号: C12Q1/6818 , C12Q1/6869 , C12Q1/6806
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