公开(公告)号：EP1608687B1

公开(公告)日：2010-01-20

申请号：EP04742303.3

申请日：2004-03-22

申请人： Centre National de La Recherche Scientifique-CNRS ,  UNIVERSITE JOSEPH FOURIER - Grenoble 1 ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ,  UNIVERSIDAD DE SEVILLA

发明人： DEFAYE, Jacques ,  ORTIZ-MELLET, Carmen ,  GARCIA-FERNANDEZ, José Manuel ,  GOMEZ-GARCIA, Maria ,  CHMURSKI, Kazimierz ,  YU, Jian-Xin

IPC分类号： C08B37/16 ,  A61K47/48 ,  A61K31/724

CPC分类号： B82Y5/00 ,  A61K47/6951 ,  C08B37/0012 ,  C08B37/0015

摘要： The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1is an OH group, all R1s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n = 1, m = 6, Z = NH2 and R1 = OH is excluded.

公开(公告)号：EP1608687A1

公开(公告)日：2005-12-28

申请号：EP04742303.3

申请日：2004-03-22

申请人： Centre National De La Recherche Scientifique-CNRS ,  UNIVERSITE JOSEPH FOURIER - Grenoble 1 ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ,  UNIVERSIDAD DE SEVILLA

发明人： DEFAYE, Jacques ,  ORTIZ-MELLET, Carmen ,  GARCIA-FERNANDEZ, José Manuel ,  GOMEZ-GARCIA, Maria ,  CHMURSKI, Kazimierz ,  YU, Jian-Xin

IPC分类号： C08B37/16 ,  A61K47/48 ,  A61K31/724

CPC分类号： B82Y5/00 ,  A61K47/6951 ,  C08B37/0012 ,  C08B37/0015

摘要： The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1is an OH group, all R1s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n = 1, m = 6, Z = NH2 and R1 = OH is excluded.

公开(公告)号：EP1689789A2

公开(公告)日：2006-08-16

申请号：EP04805527.1

申请日：2004-11-24

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE JOSEPH FOURIER ,  CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS (CSIC) ,  UNIVERSIDAD DE SEVILLA

发明人： DEFAYE, Jacques ,  ORTIZ-MELLET, Carmen ,  GARCIA-FERNANDEZ, José Manuel ,  BENITO, Juan, M. ,  GOMEZ-GARCIA, Marta ,  YU, Jian-Xin

IPC分类号： C08B37/16 ,  A61K47/40

CPC分类号： A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0012 ,  C08B37/0015

摘要： The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and n' represent an integer from 1 to 5; the A groups represent, in particular, a hydrogenated atom; X represents O or S; Y represents, in particular, a group NR1, R1, representing, in particular, a hydrogenated atom; W represents CH or N; and Z represents, in particular, a hydrogenated atom.

公开(公告)号：EP1689789B1

公开(公告)日：2009-11-11

申请号：EP04805527.1

申请日：2004-11-24

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE JOSEPH FOURIER ,  CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS (CSIC) ,  UNIVERSIDAD DE SEVILLA

发明人： DEFAYE, Jacques ,  ORTIZ-MELLET, Carmen ,  GARCIA-FERNANDEZ, José Manuel ,  BENITO, Juan, M. ,  GOMEZ-GARCIA, Marta ,  YU, Jian-Xin

IPC分类号： C08B37/16 ,  A61K47/40

CPC分类号： A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0012 ,  C08B37/0015

摘要： The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and n' represent an integer from 1 to 5; the A groups represent, in particular, a hydrogenated atom; X represents O or S; Y represents, in particular, a group NR1, R1, representing, in particular, a hydrogenated atom; W represents CH or N; and Z represents, in particular, a hydrogenated atom.

公开(公告)号：EP1086142B1

公开(公告)日：2002-03-27

申请号：EP99920913.3

申请日：1999-05-25

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： DEFAYE, Jacques ,  CROUZY, Serge ,  EVRARD, Nicolas ,  LAW, Ho

IPC分类号： C08B37/16

CPC分类号： C08B37/0012

摘要： The invention concerns a highly region-selective method for preparing a cyclodextrin C-6 monosulphonyl derivative in particular beta -cyclodextrin, which consists in reacting said cyclodextrin with a sulphonylation agent in an aqueous alkaline solution in the presence of a metal salt capable of forming a co-ordinating complex with the cyclodextrin secondary hydroxyl groups, and at the end of the reaction in recuperating said cyclodextrin C-6 monosuphonyl derivative from the reaction mixture. Cyclodextrin monosulphonyl derivatives are particularly useful as starting materials for obtaining monofunctionalised cyclodextrin derivatives.

摘要翻译： 本发明涉及用于制备环糊精C-6单磺酰基衍生物特别是β-环糊精的高度区域选择性方法，其包括使所述环糊精与磺酰化剂在碱金属水溶液中在能够形成 与环糊精仲羟基配位配合物，并在反应结束时从反应混合物中回收所述环糊精C-6单磺酰基衍生物。 环糊精单磺酰基衍生物特别可用作获得单官能化环糊精衍生物的原料。

公开(公告)号：EP2044128A2

公开(公告)日：2009-04-08

申请号：EP07823320.2

申请日：2007-07-20

申请人： Centre National De La Recherche Scientifique-CNRS

发明人： DEFAYE, Jacques ,  BALBUENA, Patricia ,  BENITO, Juan M. ,  DIAZ MOSCOSO, Alejandro ,  DI GIORGIO, Christophe ,  GARCIA FERNANDEZ, José ,  GEZE, Annabelle ,  GOMEZ GARCIA, Marta ,  ORTIZ MELLET, Carmen ,  VIERLING, Pierre ,  WOUESSIDJEWE, Denis

IPC分类号： C08B37/16 ,  A61K47/40

CPC分类号： A23L29/30 ,  A23L5/00 ,  A61K8/11 ,  A61K8/738 ,  A61K47/6951 ,  A61K2800/413 ,  A61Q19/00 ,  B82Y5/00 ,  C08B37/0012 ,  C08B37/0015 ,  C08L5/16

摘要： The present invention relates to cyclodextrins having the following formula (I): to nanostructures comprising them, to processes for preparing them, to the use thereof, and also to compositions comprising them.