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1.发明授权GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 有权糖复合物及其作为候选疫苗抗感染与志贺菌
公开(公告)号：EP1642132B1
公开(公告)日：2011-06-22
申请号：EP04744281.9
申请日：2004-07-02
申请人： INSTITUT PASTEUR , INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： PHALIPON, Armelle , NATO, Farida , MULARD, Laurence , SANSONETTI, Philippe , GRANDJEAN, Cyrille , BALEUX, Francoise , BELOT, Frédéric
IPC分类号： G01N33/569 , C07K16/12 , A61K47/48 , C07H3/06 , G01N33/563 , A61K39/112
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： The present invention relates to a saccharide selected from the group consisting of: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{B(E)CD} €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{(E)CDAB}n €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{AB(E)CD}n Wherein A, B, C, E, D and n are as defined in claim 1. The invention also relates to derivatives thereof, pharmaceutical compositions comprising said derivatives, and kit for the diagnostic of Shigella flexneri type 2a infection comprising said derivatives.
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2.发明授权SELECTIVE INHIBITION OF NF-KAPPAB ACTIVATION BY PEPTIDES DESIGNED TO DISRUPT NEMO OLIGOMERIZATION. 有权设计破坏NEMO低聚化的肽对NF-KAPPAB活化的选择性抑制。
公开(公告)号：EP1677815B1
公开(公告)日：2017-05-31
申请号：EP04769635.6
申请日：2004-09-24
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-
发明人： AGOU, Fabrice , COURTOIS, Gilles , ISRAEL, Alain , VERON, Michel , TRAINCARD, François , YAMAOKA, Shoji , BALEUX, Francoise
IPC分类号： A61K38/17
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/01
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3.发明授权
公开(公告)号：EP1677815B8
公开(公告)日：2017-08-30
申请号：EP04769635.6
申请日：2004-09-24
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-
发明人： AGOU, Fabrice , COURTOIS, Gilles , ISRAEL, Alain , VERON, Michel , TRAINCARD, François , YAMAOKA, Shoji , BALEUX, Francoise , COÏC, Yves-Marie
IPC分类号： A61K38/17
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/01
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公开(公告)号：EP2197907A2
公开(公告)日：2010-06-23
申请号：EP08856180.8
申请日：2008-10-15
IPC分类号： C07K14/52 , C12N15/62 , C07K14/475 , A61K38/18 , A61K38/19
CPC分类号： A61K38/1808 , A61K38/00 , A61K38/1825 , A61K38/185 , A61K38/1866 , C07K14/475 , C07K14/522 , C07K2319/00
摘要： The present invention relates to fragments of CXCL12 Gamma A chemokine having improved chemotaxis activity in vivo defined by an unprecedented capacity to associate and immobilise on extracellular glycans.
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5.发明公开SELECTIVE INHIBITION OF NF-KAPPAB ACTIVATION BY PEPTIDES DESIGNED TO DISRUPT NEMO OLIGOMERIZATION. 有权对灭失NEMO的寡聚化NF-KAPPA-激活肽选择性抑制
公开(公告)号：EP1677815A1
公开(公告)日：2006-07-12
申请号：EP04769635.6
申请日：2004-09-24
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： AGOU, Fabrice , COURTOIS, Gilles , ISRAEL, Alain , VERON, Michel , TRAINCARD, François , YAMAOKA, Shoji , BALEUX, Francoise
IPC分类号： A61K38/17
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/01
摘要： The present invention relates to polypeptides that inhibit the NF-κB signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
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6.发明公开GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 有权糖复合物及其作为候选疫苗抗感染与志贺菌
公开(公告)号：EP1642132A2
公开(公告)日：2006-04-05
申请号：EP04744281.9
申请日：2004-07-02
申请人： INSTITUT PASTEUR , INSERM (Institut National de la Santé et de la Recherche Medicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： PHALIPON, Armelle , NATO, Farida , MULARD, Laurence , SANSONETTI, Philippe , GRANDJEAN, Cyrille , BALEUX, Francoise , BELOT, Frédéric
IPC分类号： G01N33/569 , C07K16/12 , A61K47/48 , C07H3/06 , G01N33/563 , A61K39/112
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： The present invention relates to a saccharide selected from the group consisting of: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{B(E)CD} €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{(E)CDAB}n €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ{AB(E)CD}n Wherein A, B, C, E, D and n are as defined in claim 1. The invention also relates to derivatives thereof, pharmaceutical compositions comprising said derivatives, and kit for the diagnostic of Shigella flexneri type 2a infection comprising said derivatives.
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