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1.发明授权GENETICALLY ENCODED PROBE FOR QUANTIFICATION OF LACTATE, AND METHODS FOR QUANTIFYING METABOLIC RATES AND LACTATE TRANSPORT 有权Sa基因存储器中的探针用于LACTAT和方法，定量的代谢率与LACTATTRANSPORT定量
公开(公告)号：EP2836503B1
公开(公告)日：2016-06-08
申请号：EP12874169.1
申请日：2012-04-13
发明人： BARROS OLMEDO, Luis Felipe , SAN MARTIN, Alejandro , CEBALLO CHARPENTIER, Sebastian , FROMMER, Wolf, B.
IPC分类号： G01N33/542
CPC分类号： G01N33/5035 , C12N15/85 , G01N33/5038 , G01N33/542 , G01N33/582
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2.发明公开GENETICALLY ENCODED PROBE FOR QUANTIFICATION OF LACTATE, AND METHODS FOR QUANTIFYING METABOLIC RATES AND LACTATE TRANSPORT 有权用于定量乳酸盐的遗传编码探针，以及用于定量测定代谢速率和乳酸盐运输的方法
公开(公告)号：EP2836503A1
公开(公告)日：2015-02-18
申请号：EP12874169.1
申请日：2012-04-13
发明人： BARROS OLMEDO, Luis Felipe , SAN MARTIN, Alejandro , CEBALLO CHARPENTIER, Sebastian , FROMMER, Wolf, B.
CPC分类号： G01N33/5035 , C12N15/85 , G01N33/5038 , G01N33/542 , G01N33/582
摘要： A nanosensor for detecting and quantifying lactate in different types of samples, such as tissues, intra-cellular and subcellular compartments, with high spatial and temporal resolution is disclosed. Methods comprising use of the nanosensor for quantifying the activity of lactate transporters, rates of cellular lactate production and cellular lactate consumption, and rate of mitochondrial pyruvate consumption are also disclosed. Methods for quantifying the transformation in energy metabolism that characterizes cancer cells with single-cell resolution and for detecting interference of candidate drugs with mitochondrial energetics are additionally disclosed.
摘要翻译： 公开了一种纳米传感器，用于以高空间和时间分辨率检测和定量不同类型的样品（例如组织，细胞内和亚细胞区室）中的乳酸盐。 还公开了包括使用纳米传感器来定量乳酸转运蛋白活性，细胞乳酸产生速率和细胞乳酸消耗速率以及线粒体丙酮酸消耗速率的方法。 另外公开了量化表征具有单细胞分辨率的癌细胞和用于检测候选药物与线粒体能量学物质的干扰的能量代谢转化的方法。
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