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公开(公告)号：EP1892245B1
公开(公告)日：2015-07-29
申请号：EP06753157.4
申请日：2006-05-05
发明人： RODRIGUEZ FERNANDEZ, Rolando Eduardo , VERA ALVAREZ, Roberto , DE LA NUEZ VEULENS, Ania , MAZOLA REYES, Yuliet , PEREA RODRÍGUEZ, Silvio, Ernesto , ACEVEDO CASTRO, Boris Ernesto , MUSACCHIO LASA, Alexis , UBIETA GÓMEZ, Raimundo
IPC分类号： C07F9/22 , C07D487/04 , C07D239/42 , C07D239/36 , C07D233/54 , C07D235/14 , C07D215/18 , C07D213/82 , C07D207/36 , C07C237/30 , C07C327/44 , C07C313/06 , C07C275/36 , C07C275/22 , C07C275/18
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
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2.发明授权CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES 有权具有抗登革热病毒和其他黄病毒的抗病毒活性的化学化合物
公开(公告)号：EP2258356B1
公开(公告)日：2017-09-27
申请号：EP09714439.8
申请日：2009-02-27
发明人： MAZOLA REYES, Yuliet , CHINEA SANTIAGO, Glay , GUIROLA CRUZ, Osmany , VERA ALVAREZ, Roberto , HUERTA GALINDO, Vivian , FLEITAS SALAZAR, Noralvis , MUSACCHIO LASA, Alexis
IPC分类号： A61K31/428 , A61K31/495 , A61K31/00 , A61K31/496 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K31/425 , A61K31/381 , A61K31/404 , A61K31/433 , A61K31/40 , A61K31/4192 , A61K31/34 , A61K31/505 , A61K31/55 , A61P31/14
CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.
摘要翻译： 利用计算机获得的化学化合物制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过干扰或调节与病毒进入宿主细胞相关的几个病毒复制周期阶段和成熟后代病毒体的组装。 本发明还包括这些药物组合物用于预防性和/或治疗性治疗由所有四种登革病毒血清型和其他黄热病病毒引起的感染的用途。
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公开(公告)号：EP1892245A2
公开(公告)日：2008-02-27
申请号：EP06753157.4
申请日：2006-05-05
发明人： RODRIGUEZ FERNANDEZ, Rolando Eduardo , VERA ALVAREZ, Roberto , DE LA NUEZ VEULENS, Ania , MAZOLA REYES, Yuliet , PEREA RODRÍGUEZ, Silvio, Ernesto , ACEVEDO CASTRO, Boris Ernesto , MUSACCHIO LASA, Alexis , UBIETA GÓMEZ, Raimundo
IPC分类号： C07F9/22 , C07D487/04 , C07D239/42 , C07D239/36 , C07D233/54 , C07D235/14 , C07D215/18 , C07D213/82 , C07D207/36 , C07C237/30 , C07C327/44 , C07C313/06 , C07C275/36 , C07C275/22 , C07C275/18
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds identified by in silico molecular modelling, and having an structure that allows the blocking of the phosphorylation event, through the interaction of such compounds with the phosphorylation domain or its milieu in the substrates of the Casein Kinase 2 enzyme. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines for the treatment of diseases related with neoplasic processes.
摘要翻译： 化学化合物通过硅胶分子模拟鉴定，并具有允许阻断磷酸化事件的结构，通过这些化合物与酪蛋白激酶2酶底物中磷酸化结构域或其环境的相互作用。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与新生物相关疾病的药物中的用途。
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4.发明公开CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES 有权CHEMISCHE VERBINDUNGEN MIT ANTIVIRALER WIRKUNGGEGENÜBERDEM DENGUE-VIRUS UND ANDEREN FLAVIVIREN
公开(公告)号：EP2258356A2
公开(公告)日：2010-12-08
申请号：EP09714439.8
申请日：2009-02-27
发明人： MAZOLA REYES, Yuliet , CHINEA SANTIAGO, Glay , GUIROLA CRUZ, Osmany , VERA ALVAREZ, Roberto , HUERTA GALINDO, Vivian , FLEITAS SALAZAR, Noralvis , MUSACCHIO LASA, Alexis
IPC分类号： A61K31/00 , A61K31/496 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K31/425 , A61K31/381 , A61K31/404 , A61K31/433 , A61K31/40 , A61K31/4192 , A61K31/34 , A61K31/505 , A61K31/55 , A61P31/14
CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.
摘要翻译： 使用在硅胶中获得的化合物用于制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。 本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的所有四种血清型引起的感染。
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