公开(公告)号：EP1838674B1

公开(公告)日：2011-03-30

申请号：EP06718419.2

申请日：2006-01-13

申请人： ChemoCentryx, Inc.

发明人： UNGASHE, Solomon ,  WRIGHT, John, Jessen ,  ZENG, Yibin ,  BADAK, Arindrajit ,  CHARVAT, Trevor, T. ,  DAIRAGHI, Daniel ,  HANSEN, Derek ,  JIN, Jeff ,  MOORE, Jimmie ,  PENNELL, Andrew M.K. ,  PUNNA, Sreenivas ,  WEI, Zheng

IPC分类号： C07D213/02 ,  C07D401/02 ,  A61K31/44

CPC分类号： C07C311/21 ,  C07D213/48 ,  C07D213/61 ,  C07D213/643 ,  C07D213/70 ,  C07D213/73 ,  C07D213/76 ,  C07D213/79 ,  C07D213/81 ,  C07D213/89 ,  C07D241/22 ,  C07D263/32 ,  C07D401/04 ,  C07D405/04 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D417/12 ,  C07D471/04

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物试验表明，这些化合物可用于治疗炎症，这是CCR2的标志性疾病。 该化合物通常是芳基磺酰胺衍生物，并且可用于药物组合物，治疗CCR2介导的疾病的方法以及用于鉴定CCR2拮抗剂的测定中的对照。

公开(公告)号：EP1247103B1

公开(公告)日：2008-08-20

申请号：EP00988164.0

申请日：2000-12-18

申请人： ChemoCentryx, Inc.

发明人： SCHALL, Thomas, J. ,  PREMACK, Brett ,  MIAO, Zhenhua ,  WEI, Zheng

IPC分类号： G01N33/68 ,  C12N15/10

CPC分类号： G01N33/6863 ,  C07K14/521 ,  C07K14/7158 ,  C07K2319/00 ,  G01N33/5088 ,  G01N33/531 ,  G01N2500/00

公开(公告)号：EP1567486B1

公开(公告)日：2008-01-16

申请号：EP03816012.3

申请日：2003-11-18

申请人： ChemoCentryx, Inc.

发明人： UNGASHE, Solomon ,  WEI, Zheng ,  WRIGHT, J., J. ,  PENNELL, Andrew ,  PREMACK, Brett ,  SCHALL, Thomas, J.

IPC分类号： C07C311/21 ,  A61K31/18 ,  A61P29/00

CPC分类号： C07C311/29 ,  C07C311/21 ,  C07C311/46 ,  C07C317/14 ,  C07D213/26 ,  C07D213/50 ,  C07D213/70 ,  C07D213/74 ,  C07D213/84 ,  C07D213/89 ,  C07D241/12 ,  C07D413/12

摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.

公开(公告)号：EP1417488B1

公开(公告)日：2006-12-06

申请号：EP02739361.0

申请日：2002-05-22

申请人： ChemoCentryx, Inc.

发明人： WEI, Zheng ,  MIAO, Zhenhua

IPC分类号： G01N33/53 ,  G01N33/537 ,  C12N5/00 ,  G01N33/68

CPC分类号： G01N33/5029 ,  G01N33/5008 ,  G01N33/6863 ,  G01N2333/715 ,  G01N2500/00 ,  G01N2500/04

摘要： The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.

公开(公告)号：EP1461061A2

公开(公告)日：2004-09-29

申请号：EP02786859.5

申请日：2002-12-02

申请人： Chemocentryx, Inc.

发明人： BURNS, Jennifer, M. ,  MIAO, Zhenhua ,  WEI, Zheng ,  HOWARD, Maureen, C. ,  PREMACK, Brett, A. ,  SCHALL, Thomas, J.

IPC分类号： A61K38/00 ,  G01N33/53 ,  G01N33/537 ,  C12N15/00 ,  C12N5/00

CPC分类号： G01N33/6863 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57449 ,  G01N2500/10

摘要： Compositions and Methods for Detecting and Treating Diseases and Conditions Related to Chemokine ReceptorsABSTRACT OF THE DISCLOSUREThe present invention provides methods for identifying an agent that specifically binds and/or modulates one topology of chemokine receptor but not a second topology of the receptor. Such agents are useful as therapeutics for diseases or conditions associated with a particular chemokine receptor topology. Moreover, the agents are useful for detecting a particular topology of a chemokine receptor, thereby diagnosing disease or predisposition for a disease. In addition, the agents are useful for identifying and isolating cells that express a particular topology of a chemokine receptor.

公开(公告)号：EP1499886A1

公开(公告)日：2005-01-26

申请号：EP02805706.5

申请日：2002-10-21

申请人： Chemocentryx, Inc.

发明人： SCHALL, Thomas, J. ,  MIAO, Zhenhua ,  BERAHOVICH, Robert ,  WEI, Zheng ,  HOWARD, Maureen ,  PREMACK, Brett

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61K39/385 ,  A61K39/09 ,  A61K39/02 ,  A01N43/40 ,  A01N25/00

CPC分类号： C07K14/523 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55522 ,  Y02A50/39 ,  Y02A50/401 ,  Y02A50/466 ,  Y02A50/484

摘要： This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.

公开(公告)号：EP1417488A2

公开(公告)日：2004-05-12

申请号：EP02739361.0

申请日：2002-05-22

申请人： Chemocentryx, Inc.

发明人： WEI, Zheng ,  MIAO, Zhenhua

IPC分类号： G01N33/53 ,  G01N33/537 ,  C12N5/00

CPC分类号： G01N33/5029 ,  G01N33/5008 ,  G01N33/6863 ,  G01N2333/715 ,  G01N2500/00 ,  G01N2500/04

摘要： The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.

公开(公告)号：EP1838674B9

公开(公告)日：2011-11-02

申请号：EP06718419.2

申请日：2006-01-13

申请人： ChemoCentryx, Inc.

发明人： UNGASHE, Solomon ,  WRIGHT, John, Jessen ,  ZENG, Yibin ,  BADAK, Arindrajit ,  CHARVAT, Trevor, T. ,  DAIRAGHI, Daniel ,  HANSEN, Derek ,  JIN, Jeff ,  MOORE, Jimmie ,  PENNELL, Andrew M.K. ,  PUNNA, Sreenivas ,  WEI, Zheng

IPC分类号： C07D213/02 ,  C07D401/02 ,  A61K31/44

CPC分类号： C07C311/21 ,  C07D213/48 ,  C07D213/61 ,  C07D213/643 ,  C07D213/70 ,  C07D213/73 ,  C07D213/76 ,  C07D213/79 ,  C07D213/81 ,  C07D213/89 ,  C07D241/22 ,  C07D263/32 ,  C07D401/04 ,  C07D405/04 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D417/12 ,  C07D471/04

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：EP1499886B1

公开(公告)日：2010-01-13

申请号：EP02805706.5

申请日：2002-10-21

申请人： ChemoCentryx, Inc.

发明人： SCHALL, Thomas, J. ,  MIAO, Zhenhua ,  BERAHOVICH, Robert ,  WEI, Zheng ,  HOWARD, Maureen ,  PREMACK, Brett

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61K39/385 ,  A61K39/09 ,  A61K39/02 ,  A01N43/40 ,  A01N25/00

CPC分类号： C07K14/523 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55522 ,  Y02A50/39 ,  Y02A50/401 ,  Y02A50/466 ,  Y02A50/484

摘要： This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.

公开(公告)号：EP1562940B1

公开(公告)日：2007-05-30

申请号：EP03796416.0

申请日：2003-11-17

申请人： ChemoCentryx, Inc.

发明人： UNGASHE, Solomon ,  WEI, Zheng ,  WRIGHT, J., J. ,  PENNELL, Andrew, M.K.

IPC分类号： C07D213/89 ,  A61K31/44 ,  A61P29/00

CPC分类号： C07C311/29 ,  C07C311/21 ,  C07C311/46 ,  C07C317/14 ,  C07D213/26 ,  C07D213/50 ,  C07D213/70 ,  C07D213/74 ,  C07D213/84 ,  C07D213/89 ,  C07D241/12 ,  C07D413/12

摘要： Compounds of formula (I) (in which the variables L, X, Y and Z are as defined in the claims) are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulphonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.