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公开(公告)号：EP3178821B1
公开(公告)日：2020-05-06
申请号：EP15830563.1
申请日：2015-08-05
发明人： WANG, Lulu , ZHANG, Xiquan , LIU, Fei , ZHU, Yizhong , GAO, Chao , TANG, Song , ZHU, Bo , TANG, Jianqiu
IPC分类号： C07D491/048 , A61K31/4355 , A61P35/00 , A61P29/00
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公开(公告)号：EP3505516A1
公开(公告)日：2019-07-03
申请号：EP17842961.9
申请日：2017-08-24
申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd. , Centaurus BioPharma Co., Ltd.
发明人： TANG, Song , ZHU, Yizhong , LIU, Fei , ZHOU, Jie , CHEN, Zhilin , XU, Hongjiang , TIAN, Xin
IPC分类号： C07D401/12 , C07C57/145 , C07C51/41 , A61K31/517 , A61P35/00
摘要： Disclosed are a crystal of a maleate of a compound of formula (I), a preparation method for the crystal, a crystallization composition of same, a pharmaceutical composition of same, and uses thereof in preventing and treating a tumor.
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公开(公告)号：EP3476841A1
公开(公告)日：2019-05-01
申请号：EP17814745.0
申请日：2017-06-23
申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd. , Centaurus BioPharma Co., Ltd.
发明人： ZHU, Yizhong , TANG, Jianqiu , LIU, Fei , ZHANG, Xiquan , GU, Hongmei , ZHU, Bo , WANG, Lulu , TANG, Song , ZHANG, Yanyang
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00 , A61P35/02
摘要： The present application belongs to the field of medicinal chemistry, and relates to crystals of an aniline pyrimidine compound serving as an EGFR inhibitor. Specifically, the present application relates to crystal A, crystal B and crystal C of N-(2-((2-(dimethyl amino)ethyl)(methyl)amino)-4-methoxy-5-(4-(3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-base)pyrimidine-2-base amino)phenyl)acrylamide (formula I) hydrochloride, and also relates to the method for preparing the crystal A, the crystal B and the crystal C, a crystal composition comprising the crystal A, the crystal B, and the crystal C, a pharmaceutical composition comprising the crystal A, the crystal B and the crystal C or the crystal composition thereof, and medical uses thereof. The crystal A, the crystal B and the crystal C in the present application has the advantages of high purity, high crystallization degree, good stability and the like.
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4.发明公开6-ARYL AMINO PYRIDONE FORMAMIDE COMPOUND CRYSTAL AND PREPARATION METHOD THEREFOR 审中-公开6-芳基氨基吡啶酮甲酰胺化合物晶体及其制备方法
公开(公告)号：EP3178821A1
公开(公告)日：2017-06-14
申请号：EP15830563.1
申请日：2015-08-05
发明人： WANG, Lulu , ZHANG, Xiquan , LIU, Fei , ZHU, Yizhong , GAO, Chao , TANG, Song , ZHU, Bo , TANG, Jianqiu
IPC分类号： C07D491/048 , A61K31/4355 , A61P35/00 , A61P29/00
CPC分类号： C07D491/048 , A61K31/4355 , C07B2200/13
摘要： Provided are 6-aryl amino pyridone formamide compound crystal and a preparation method therefor. In the present invention, 6-(2-chlorine-4-iodopheny amino)-N-(2-hydroxyl ethyoxyl)-5-methyl-4-oxo-4,5-dihydrofuran[3,2-c]pyridine-7-formamide is dissolved in a polar aprotic solvent, a second solvent is added for recrystallization, and a crystal is obtained. The crystallization method is simple to operate and conducive for industrial production. The produced crystal has high purity, good stability, and is conductive for pharmaceutical production and storage.
摘要翻译： 本发明提供6-芳基氨基吡啶酮甲酰胺化合物结晶及其制备方法。 在本发明中，6-（2-氯-4-氨基iodopheny）-N-（2-羟基ethyoxyl）-5-甲基-4-氧代-4,5-二氢呋喃并[3,2-c]吡啶-7- - 甲酰胺溶于极性非质子溶剂中，加入第二溶剂进行重结晶，得到晶体。 结晶方法操作简单，有利于工业生产。 所生产的晶体纯度高，稳定性好，对药物生产和储存具有导电性。
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公开(公告)号：EP3272746B1
公开(公告)日：2019-12-25
申请号：EP16767717.8
申请日：2016-03-18
申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： ZHANG, Xiquan , TANG, Song , FENG, Weiwei , TIAN, Xin , CHEN, Zhilin , GU, Hongmei , XU, Hongjiang , LIU, Fei
IPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , A61K31/517 , A61K31/5377 , A61P35/00 , A61K31/4427 , A61K45/06 , C07D239/94 , C07D211/40
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公开(公告)号：EP4052713A1
公开(公告)日：2022-09-07
申请号：EP20883328.5
申请日：2020-10-30
申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. , Lianyungang Runzhong Pharmaceutical Co., Ltd. , Shouyao Holdings (Beijing) Co., Ltd.
发明人： SHANG, Lei , HE, Jiali , YAN, Caixia , DONG, Ping , ZHOU, Jie , SUN, Yingying , XU, Yi , CHEN, Zhilin , TANG, Song
IPC分类号： A61K31/78 , A61K47/58 , C07D403/12 , C07D401/12 , C07D405/14 , C07D401/14 , A61P35/00
摘要： A solid pharmaceutical composition comprising a quinazoline derivative or a medicinal salt thereof, and a preparation method therefor. Specifically, provided is a solid pharmaceutical composition comprising N 6 -(1-acryloylpiperidin-4-yl)-N 4 -(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine or a medicinal salt thereof, and a preparation method therefor and use thereof.
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公开(公告)号：EP3858832A1
公开(公告)日：2021-08-04
申请号：EP19878278.1
申请日：2019-10-29
发明人： LIU, Fei , FENG, Weiwei , WANG, Bin , XU, Hongjiang , WANG, Jinan , ZHANG, Xiquan , WANG, Shanchun , LIU, Yanlong , ZHANG, Jianqing , YAO, Yiyan , TANG, Xujing , SHI, Wei , ZHANG, Hongying , LI, Yang , TANG, Song , ZHU, Yizhong , LIU, Limin , GU, Hongmei , YANG, Ling
IPC分类号： C07D471/04 , C07D211/96 , C07D215/20 , A61K31/404 , A61P35/00
摘要： Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.
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公开(公告)号：EP3272746A1
公开(公告)日：2018-01-24
申请号：EP16767717.8
申请日：2016-03-18
申请人： Chai Tai Tianqing Pharmaceutical Group Co., Ltd. , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： ZHANG, Xiquan , TANG, Song , FENG, Weiwei , TIAN, Xin , CHEN, Zhilin , GU, Hongmei , XU, Hongjiang , LIU, Fei
IPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , A61K31/517 , A61K31/5377 , A61P35/00
摘要： The present application relates to maleates of a compound of Formula I, methods for preparing the same, pharmaceutical compositions thereof and uses thereof in the treatment of tumors, such as non-small cell lung cancer, breast cancer, and other malignant tumors.
摘要翻译： 本申请涉及式I化合物的马来酸盐，其制备方法，其药物组合物及其在治疗肿瘤如非小细胞肺癌，乳腺癌和其他恶性肿瘤中的用途。
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