公开(公告)号：EP2012799B1

公开(公告)日：2016-08-24

申请号：EP07760797.6

申请日：2007-04-18

申请人： Chimerix, Inc. ,  The Regents of the University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  RUIZ, Jacqueline ,  ALMOND, Merrick R. ,  PAINTER, George R. ,  RILEY, Timothy, A. ,  FRANCOM, Paula

IPC分类号： C07D473/34 ,  C07D239/47 ,  C07D473/00 ,  C07D239/52 ,  C07F9/40 ,  A61K31/675 ,  A61P31/12 ,  A61P33/00

CPC分类号： C07F9/65121 ,  C07F9/6552 ,  C07F9/65616 ,  C07F9/657172

公开(公告)号：EP2012799A2

公开(公告)日：2009-01-14

申请号：EP07760797.6

申请日：2007-04-18

申请人： Chimerix, Inc. ,  The Regents Of The University Of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  RUIZ, Jacqueline ,  ALMOND, Merrick R. ,  PAINTER, George R. ,  RILEY, Timothy, A. ,  FRANCOM, Paula

IPC分类号： A61K31/675 ,  C07F9/40 ,  C07D473/00 ,  C07D473/34 ,  C07D239/47 ,  C07D239/52

CPC分类号： C07F9/65121 ,  C07F9/6552 ,  C07F9/65616 ,  C07F9/657172

摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.

公开(公告)号：EP4185300A1

公开(公告)日：2023-05-31

申请号：EP21846589.6

申请日：2021-07-24

申请人： The Regents of the University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James ,  VALIAEVA, Nadejda ,  SCHOOLEY, Robert T.

IPC分类号： A61K31/7068 ,  A61K39/395 ,  A61P31/14

公开(公告)号：EP2970346A1

公开(公告)日：2016-01-20

申请号：EP14764430.6

申请日：2014-03-14

申请人： The Regents of the University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  VALIAEVA, Nadejda

IPC分类号： C07F9/40 ,  C07F9/6512 ,  C07F9/6524 ,  A61K31/675 ,  A61K31/662 ,  A61K31/522 ,  A61K31/513 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  A61P35/00

CPC分类号： A61K31/685 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K31/675 ,  C07F9/65121 ,  C07F9/65583 ,  C07F9/6561 ,  C07F9/65616 ,  Y02A50/467

摘要： The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

摘要翻译： 本公开尤其涉及用于治疗病毒性疾病和癌症的组合物和方法。 公开了亲脂性抗病毒和抗癌无环核苷膦酸二酯，其制备方法，以及使用该化合物治疗病毒性疾病和癌症的方法。

公开(公告)号：EP1866319B1

公开(公告)日：2011-11-23

申请号：EP06799899.7

申请日：2006-03-30

申请人： The Regents of The University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  CHOO, Hyunah

IPC分类号： C07F9/6561 ,  C07F9/6512 ,  C07H19/20 ,  C07H19/10 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07F9/65616 ,  C07F9/65121 ,  C07H19/10 ,  C07H19/20

摘要： Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are 5-phosphono-pent-2-en-l-yl nucleosides and esters thereof.

公开(公告)号：EP3401320B1

公开(公告)日：2020-05-13

申请号：EP18179904.0

申请日：2014-03-14

申请人： The Regents of the University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  VALIAEVA, Nadejda

IPC分类号： C07F9/6512 ,  C07F9/6558 ,  A61K31/675 ,  A61K31/662 ,  A61K31/522 ,  A61K31/513 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  A61P35/00 ,  C07F9/6561

公开(公告)号：EP3401320A1

公开(公告)日：2018-11-14

申请号：EP18179904.0

申请日：2014-03-14

申请人： The Regents of the University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  VALIAEVA, Nadejda

IPC分类号： C07F9/6512 ,  C07F9/6558 ,  A61K31/675 ,  A61K31/662 ,  A61K31/522 ,  A61K31/513 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  A61P35/00 ,  C07F9/6561

摘要： The present disclosure relates, inter alia, to a compound of Formula (la):

or a pharmaceutically acceptable salt thereof for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia to a subject in need thereof wherein:
B Nuc ( a ) is selected from the group consisting of:


L a is an unsubstituted C 13-29 heteroalkyl;
R a is selected from the group consisting of an unsubstituted C 1-6 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl(C 1-6 alkyl), a substituted or unsubstituted heteroaryl(C 1-6 alkyl) and a substituted or unsubstituted heterocycloalkyl(C 1-6 alkyl);
X a is hydrogen, an unsubstituted C 1-6 alkyl, a halogen substituted C 1-6 alkyl, a hydroxy substituted C 1-6 alkyl or an unsubstituted C 1-6 alkoxy;
wherein alkyl is fully saturated; and
wherein the substituent is selected from the following moieties: -OH, -NH 2 , -SH, -CN, -CF 3 , -NO 2 , oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.

公开(公告)号：EP2970346B1

公开(公告)日：2018-08-08

申请号：EP14764430.6

申请日：2014-03-14

申请人： The Regents of the University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  VALIAEVA, Nadejda

IPC分类号： C07F9/6512 ,  C07F9/6558 ,  A61K31/675 ,  A61K31/662 ,  A61K31/522 ,  A61K31/513 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  A61P35/00 ,  C07F9/6561

CPC分类号： A61K31/675 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P35/02 ,  C07F9/6512 ,  C07F9/65583 ,  C07F9/6561 ,  C07F9/65616 ,  Y02A50/467

摘要： The present disclosure relates, inter alia, to a compound of Formula (la): or a pharmaceutically acceptable salt thereof for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia to a subject in need thereof wherein: B Nuc ( a ) is selected from the group consisting of: L a is an unsubstituted C 13-29 heteroalkyl; R a is selected from the group consisting of an unsubstituted C 1-6 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl(C 1-6 alkyl), a substituted or unsubstituted heteroaryl(C 1-6 alkyl) and a substituted or unsubstituted heterocycloalkyl(C 1-6 alkyl); X a is hydrogen, an unsubstituted C 1-6 alkyl, a halogen substituted C 1-6 alkyl, a hydroxy substituted C 1-6 alkyl or an unsubstituted C 1-6 alkoxy; wherein alkyl is fully saturated; and wherein the substituent is selected from the following moieties: -OH, -NH 2 , -SH, -CN, -CF 3 , -NO 2 , oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.

公开(公告)号：EP3194411A1

公开(公告)日：2017-07-26

申请号：EP15842133.9

申请日：2015-09-15

申请人： The Regents of the University of California

发明人： HOSTETLER, Karl Y. ,  BEADLE, James R. ,  VALIAEVA, Nadejda

IPC分类号： C07F9/6561

CPC分类号： A61K31/522 ,  A61K8/24 ,  A61K31/00 ,  C07F9/65616 ,  C07F9/657181 ,  C07F9/65742 ,  C07F9/65744

摘要： Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.

摘要翻译： 本文特别公开了无环核苷酸类似物和使用无环核苷酸类似物治疗和/或改善乳头瘤病毒感染的方法。