公开(公告)号：EP2966066A1

公开(公告)日：2016-01-13

申请号：EP14760605.7

申请日：2014-03-04

申请人： Consejo Superior De Investigaciones Científicas (CSIC) ,  Centro de Investigación Biomédica en Red (CIBER) ,  Universidad Autónoma De Barcelona (UAB)

发明人： MARCO COLÁS, María Pilar ,  PASCUAL DURÁN, Nuria ,  PASTELLS DÍEZ, Carme ,  SANCHEZ BAEZA, Francisco ,  VILLAVERDE CORRALES, Antonio Pedro ,  RODRÍGUEZ CARMONA, Escarlata

IPC分类号： C07D241/46 ,  C07K16/12 ,  G01N33/569

CPC分类号： G01N33/5308 ,  C07D241/46 ,  C07K16/44 ,  C07K19/00 ,  G01N33/56911 ,  G01N2333/21 ,  G01N2469/10

摘要： The invention relates to a compound of general formula (I) and to the use thereof as a haptene.

The invention also relates to a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable marking agent, or with a polymer or support, and to the use thereof for producing antibodies. The invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

摘要翻译： 本发明涉及通式（I）的化合物和涉及其作为半抗原。 因此，本发明涉及与载体蛋白或其片段，所述化合物I的共轭物，用可检测的标记剂，或者与聚合物或支撑，和它们的用途用于产生抗体。 因此本发明涉及一种用于一hydroxyphenazine的检测和/或定量和/或使用绿脓菌素所述抗体和缀合物用于检测由铜绿假单胞菌引起的感染的方法。

公开(公告)号：EP2966066B1

公开(公告)日：2018-02-14

申请号：EP14760605.7

申请日：2014-03-04

申请人： Consejo Superior De Investigaciones Científicas (CSIC) ,  Consorcio Centro de Investigación Biomédica en Red M.P. ,  Universitat Autónoma De Barcelona (UAB)

发明人： MARCO COLÁS, María Pilar ,  PASCUAL DURÁN, Nuria ,  PASTELLS DÍEZ, Carme ,  SANCHEZ BAEZA, Francisco ,  VILLAVERDE CORRALES, Antonio Pedro ,  RODRÍGUEZ CARMONA, Escarlata

IPC分类号： C07D241/46 ,  C07K16/12 ,  G01N33/569

CPC分类号： G01N33/5308 ,  C07D241/46 ,  C07K16/44 ,  C07K19/00 ,  G01N33/56911 ,  G01N2333/21 ,  G01N2469/10

摘要： The invention relates to a compound of general formula (I) and to the use thereof as a haptene. The invention also relates to a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable marking agent, or with a polymer or support, and to the use thereof for producing antibodies. The invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

公开(公告)号：EP2866839B1

公开(公告)日：2018-08-15

申请号：EP13732179.0

申请日：2013-06-28

申请人： Consejo Superior De Investigaciones Científicas (CSIC) ,  Fundació Parc Científic de Barcelona ,  CIBER Centro de Investigación Biomédica en Red ,  Fundació Institut de Recerca Biomèdica (IRB Barcelona) ,  Universitat de Barcelona ,  Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca ,  Universitat Autònoma de Barcelona

发明人： VENTOSA RULL, Leonor ,  VECIANA MIRÓ, Jaume ,  CABRERA PUIG, Ingrid ,  ELIZONDO SAEZ DE VICUÑA, Elisa ,  MELGAREJO DIAZ, Marta ,  ROYO EXPÓSITO, Miriam ,  ALBERICIO PALOMERA, Fernando ,  PULIDO MARTINEZ, Daniel ,  SALA VERGÉS, Santiago ,  CORCHERO NIETO, Jose Luis ,  SCHWARTZ NAVARRO, Simón ,  ABASOLO OLAORTUA, Ibane ,  VILLAVERDE CORRALES, Antonio Pedro

IPC分类号： A61K47/50

CPC分类号： A61K47/646 ,  A61K38/47 ,  A61K47/54 ,  A61K47/554 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6435 ,  A61K47/6911 ,  A61K47/6915 ,  C12Y302/01022 ,  Y10T428/2982

摘要： The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.

公开(公告)号：EP2866839A1

公开(公告)日：2015-05-06

申请号：EP13732179.0

申请日：2013-06-28

申请人： Consejo Superior De Investigaciones Científicas (CSIC) ,  Fundació Parc Científic de Barcelona ,  CIBER Centro de Investigación Biomédica en Red ,  Fundació Institut de Recerca Biomèdica (IRB Barcelona) ,  Universitat de Barcelona ,  Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca ,  Universitat Autònoma De Barcelona

发明人： VENTOSA RULL, Leonor ,  VECIANA MIRÓ, Jaume ,  CABRERA PUIG, Ingrid ,  ELIZONDO SAEZ DE VICUÑA, Elisa ,  MELGAREJO DIAZ, Marta ,  ROYO EXPÓSITO, Miriam ,  ALBERICIO PALOMERA, Fernando ,  PULIDO MARTINEZ, Daniel ,  SALA VERGÉS, Santiago ,  CORCHERO NIETO, Jose Luis ,  SCHWARTZ NAVARRO, Simón ,  ABASOLO OLAORTUA, Ibane ,  VILLAVERDE CORRALES, Antonio Pedro

IPC分类号： A61K47/48

CPC分类号： A61K47/646 ,  A61K38/47 ,  A61K47/54 ,  A61K47/554 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6435 ,  A61K47/6911 ,  A61K47/6915 ,  C12Y302/01022 ,  Y10T428/2982

摘要： The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.

摘要翻译： 本发明涉及其中固醇通过醚键与引导配体结合的水溶性聚合物官能化的缀合物。 这些缀合物提高其携带囊泡的物理化学和递送性质，使其更稳定，均匀和有效。 还描述了其制备方法，含有所述脂质体的药物组合物及其治疗用途。