利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

98 records (took 0.032 seconds)

    PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS
    2.
    发明公开
    PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS 审中-公开
    PHENAZINDERIVATE ALS ANTIMIKROBIELLE MITTEL

    公开(公告)号：EP3086791A4

    公开(公告)日：2017-06-14

    申请号：EP14873432

    申请日：2014-12-23

    Applicant: UNIV FLORIDA

    Inventor： HUIGENS ROBERT WILLIAM III ,  JIN SHOUGUANG

    IPC: A61K31/498 ,  C07D241/46

    CPC classification number: C07D241/46 ,  A61K31/498 ,  A61K45/06 ,  C07D241/38 ,  C07D405/12 ,  C07D409/12 ,  A61K2300/00

    Abstract: The present invention provides novel phenazine derivatives, such as compounds of Formula (I) and (II), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be anitmicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium), killing a microorganism (e.g., a bacterium), inhibiting the formation and/or growth of a biofilm, or reducing or clearing a biofilm.

    Abstract translation: 本发明提供新的吩嗪衍生物，如式（I）和（II）的化合物及其药学上可接受的盐。 预期本发明的化合物是抗微生物剂并且可以通过微生物战争策略（例如基于活性氧（ROS）的竞争策略）起作用。 本发明还提供涉及本发明化合物的药物组合物，试剂盒，用途和方法，并且可用于预防或治疗受试者中的微生物感染（例如细菌感染），抑制生长和/或生殖 （例如细菌），杀灭微生物（例如细菌），抑制生物膜的形成和/或生长，或减少或清除生物膜。

    IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS
    4.
    发明公开
    IMPROVED METHOD OF PRODUCING POLYMERIC PHENAZONIUM COMPOUNDS 审中-公开
    改进的方法制备聚合物吡唑酮鎓

    公开(公告)号：EP2619244A1

    公开(公告)日：2013-07-31

    申请号：EP11827508.0

    申请日：2011-09-22

    Applicant: MacDermid Acumen, Inc.

    Inventor： KROL, Andrew, M. ,  LONG, Ernest ,  TAYTSAS, Lev

    IPC: C08G63/48

    CPC classification number: C08G73/0633 ,  C07D241/46 ,  C08G73/0694 ,  C25D3/38

    Abstract: A process of making a polymeric phenazonium compound having the general formula: wherein R
    1 , R
    2 , R
    4 , R
    5 , R
    6 , R
    8 and R
    9 are the same or different, and represent hydrogen, a low alkyl or a substituted aryl, R
    3 stalls as NH
    2 and is diazotized followed by polymerization, R
    5 and R
    8 may alternatively represent monomeric or polymeric phenazonium radicals, R
    7 is a carbon in the aromatic ring, and wherein R
    X -N-R
    Y represents a substituted amine, and R
    x and R
    y represent any combination of CH
    3 , C
    2 H
    5 , and hydrogen, except that R
    x and R
    Y cannot both be hydrogen, A is an acid radical, and n is an integer from 2 to 100. The polymeric phenazonium compound is usable in as an additive in a metal plating bath. The method includes the steps of: a) dissolving an effective amount of an amino compound in a formic acid solution; b) adding a nitrite salt to diazotize the amino compound; and c) adding sulfamic acid to neutralize any excess nitrous acid that may be fonned in step b), whereby a polymeric phenazonium compound is produced.

    NOVEL SEH INHIBITORS AND THEIR USE
    8.
    发明公开
    NOVEL SEH INHIBITORS AND THEIR USE 有权
    新SEH抑制剂及其用途

    公开(公告)号：EP2214487A1

    公开(公告)日：2010-08-11

    申请号：EP08838314.6

    申请日：2008-10-10

    Applicant: GlaxoSmithKline LLC

    Inventor： DING, Yun ,  THALJI, Reema, K. ,  MARINO, Joseph, Paul, Jr.

    IPC: A01N43/66 ,  A61K31/53

    CPC classification number: C07D241/46 ,  C07D251/18 ,  C07D251/52 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/04

    Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Patent Agency Ranking