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11 条记录 (耗时 0.02 秒)

    COATED IMPLANTABLE MEDICAL DEVICE
    3.
    发明公开
    COATED IMPLANTABLE MEDICAL DEVICE 有权
    涂层纸，植入式医疗设备

    公开(公告)号：EP1330273A1

    公开(公告)日：2003-07-30

    申请号：EP01987197.9

    申请日：2001-10-31

    申请人： Cook Incorporated ,  MED INSTITUTE, INC.

    发明人： RAGHEB, Anthony, O. ,  BATES, Brian, L. ,  STEWART, Joseph, M., IV ,  BOURDEAU, William, J. ,  CHOULES, Brian, D. ,  PURDY, James, D. ,  FEARNOT, Neal, E.

    IPC分类号： A61L31/16 ,  A61L27/54

    CPC分类号： A61L27/54 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/606

    摘要： A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 νin. (about 250 nm) and a surface roughness range between about 1/νin. and about 100 νin. (about 25 nm and about 2.5 νm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

    COATED IMPLANTABLE MEDICAL DEVICE
    4.
    发明授权
    COATED IMPLANTABLE MEDICAL DEVICE 有权
    涂层纸，植入式医疗设备

    公开(公告)号：EP1330273B1

    公开(公告)日：2007-07-25

    申请号：EP01987197.9

    申请日：2001-10-31

    申请人： Cook Incorporated ,  MED INSTITUTE, INC.

    发明人： RAGHEB, Anthony, O. ,  BATES, Brian, L. ,  STEWART, Joseph, M., IV ,  BOURDEAU, William, J. ,  CHOULES, Brian, D. ,  PURDY, James, D. ,  FEARNOT, Neal, E.

    IPC分类号： A61L31/16 ,  A61L27/54

    CPC分类号： A61L27/54 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/606

    摘要： A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 νin. (about 250 nm) and a surface roughness range between about 1/νin. and about 100 νin. (about 25 nm and about 2.5 νm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

    INTRAVASCULAR MEDICAL DEVICE
    5.
    发明公开
    INTRAVASCULAR MEDICAL DEVICE 无效
    血管内的医疗器械

    公开(公告)号：EP0716616A1

    公开(公告)日：1996-06-19

    申请号：EP95900402.0

    申请日：1994-08-29

    申请人： MED INSTITUTE, INC.

    发明人： FEARNOT, Neal, E. ,  RAGHEB, Anthony, O. ,  VOORHEES, William, D., III

    IPC分类号： A61L27 ,  A61L29 ,  A61L31 ,  A61L33

    CPC分类号： A61L31/16 ,  A61L29/16 ,  A61L33/0011 ,  A61L33/0047 ,  A61L2300/254 ,  A61L2300/42

    摘要： An intravascular medical device (10) having a structure (11) shaped and sized for introduction into the vascular system of a patient, the structure having biologically inert properties and a thrombolytic agent (13) or an antithrombogenic agent (14). The thrombolytic agent advantageously dissolves or breaks up the formation of thrombus on the surface of the structure when placed in the vascular system of a patient. The antithrombogenic agent inhibits the formation of thrombus on the surface of the medical device. The structure also includes a biologically inert material (15) that forms either at least part of the base material of the device or a coating material (22) on the base material. The thrombolytic agent and/or antithrombogenic agent are homogeneously combined with the base and/or coating material.

    IMPLANTABLE MEDICAL DEVICE WITH PARTICULATE COATING
    6.
    发明公开
    IMPLANTABLE MEDICAL DEVICE WITH PARTICULATE COATING 有权
    与颗粒涂层植入式医疗设备

    公开(公告)号：EP2054101A2

    公开(公告)日：2009-05-06

    申请号：EP07836532.7

    申请日：2007-08-03

    申请人： Med Institute, Inc.

    发明人： GREWE, David, D. ,  VOORHEES, William, D. ,  RAGHEB, Anthony, O.

    IPC分类号： A61L31/08 ,  A61L27/28

    CPC分类号： A61L31/082

    摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device can include a frame with a vessel-engaging region on at least a portion of the medical device. The vessel- engaging region may be a particulate coating configured and adapted to engage the interior wall of a body vessel or to attach a material, such as a valve leaflet or graft material, to the frame. Methods of making an implantable medical device and methods of treating a subject are also disclosed.

    INTRAVASCULAR MEDICAL DEVICE
    7.
    发明授权
    INTRAVASCULAR MEDICAL DEVICE 无效
    血管内的医疗器械

    公开(公告)号：EP0716616B1

    公开(公告)日：2003-10-08

    申请号：EP95900402.9

    申请日：1994-08-29

    申请人： MED INSTITUTE, INC.

    发明人： FEARNOT, Neal, E. ,  RAGHEB, Anthony, O. ,  VOORHEES, William, D., III

    IPC分类号： A61L33/00 ,  A61L29/00 ,  A61L27/00

    CPC分类号： A61L31/16 ,  A61L29/16 ,  A61L33/0011 ,  A61L33/0047 ,  A61L2300/254 ,  A61L2300/42

    摘要： An intravascular medical device (10) having a structure (11) shaped and sized for introduction into the vascular system of a patient, the structure having biologically inert properties and a thrombolytic agent (13) or an antithrombogenic agent (14). The thrombolytic agent advantageously dissolves or breaks up the formation of thrombus on the surface of the structure when placed in the vascular system of a patient. The antithrombogenic agent inhibits the formation of thrombus on the surface of the medical device. The structure also includes a biologically inert material (15) that forms either at least part of the base material of the device or a coating material (22) on the base material. The thrombolytic agent and/or antithrombogenic agent are homogeneously combined with the base and/or coating material.

    ENDOVASCULAR FILTER
    9.
    发明公开
    ENDOVASCULAR FILTER 审中-公开
    ENDOVASKULÄRER过滤器

    公开(公告)号：EP1412014A2

    公开(公告)日：2004-04-28

    申请号：EP02744350.6

    申请日：2002-06-14

    申请人： Cook Incorporated

    发明人： GRIFFIN, Dennis ,  MOLGAARD-NIELSEN, Arne ,  RAGHEB, Anthony, O. ,  LEONARD II, Raymond, B.

    IPC分类号： A61M29/00

    CPC分类号： A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0086

    摘要： Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if 5 desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.