公开(公告)号：EP3207026B1

公开(公告)日：2018-12-12

申请号：EP15805323.1

申请日：2015-10-14

申请人： Council of Scientific and Industrial Research

发明人： VISHWAKARMA, Ram ,  BHARATE, Sandip Bibishan ,  KUMAR, Ajay ,  SINGH, Baljinder ,  KUMAR, Ashok ,  BHUSHAN, Shashi ,  HAMID, Abid ,  JOSHI, Prashant ,  GURU, Santosh Kumar ,  KUMAR, Suresh ,  HUSSAIN, Aashiq ,  QAZI, Asif Khurshid ,  BHARATE, Sonali Sandip ,  SHARMA, Parduman ,  SAXENA, Ajit Kumar ,  MONDHE, Dilip Manikrao ,  MAHAJAN, Girish ,  WANI, Zahoor

IPC分类号： C07C233/41

CPC分类号： C07C233/41 ,  A61K31/165 ,  C07C231/12 ,  C07C2603/34

摘要： The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.

公开(公告)号：EP3207026A1

公开(公告)日：2017-08-23

申请号：EP15805323.1

申请日：2015-10-14

申请人： Council of Scientific and Industrial Research

发明人： VISHWAKARMA, Ram ,  BHARATE, Sandip Bibishan ,  KUMAR, Ajay ,  SINGH, Baljinder ,  KUMAR, Ashok ,  BHUSHAN, Shashi ,  HAMID, Abid ,  JOSHI, Prashant ,  GURU, Santosh Kumar ,  KUMAR, Suresh ,  HUSSAIN, Aashiq ,  QAZI, Asif Khurshid ,  BHARATE, Sonali Sandip ,  SHARMA, Parduman ,  SAXENA, Ajit Kumar ,  MONDHE, Dilip Manikrao ,  MAHAJAN, Girish ,  WANI, Zahoor

IPC分类号： C07C233/41

CPC分类号： C07C233/41 ,  A61K31/165 ,  C07C231/12 ,  C07C2603/34

摘要： The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.

摘要翻译： 本发明涉及式I化合物，其中R如本文所述。 本发明特别涉及10-取代的类秋水仙碱的合成和抗增殖活性。 本发明的化合物可以用于预防或治疗癌症疾病。