公开(公告)号：EP2810661A3

公开(公告)日：2015-04-29

申请号：EP14002542.0

申请日：2010-09-03

申请人： Curevac GmbH

发明人： Baumhof, Patrick ,  Schlake, Thomas

IPC分类号： A61K47/48 ,  A61P43/00

CPC分类号： A61K48/0041 ,  A61K47/60 ,  A61K47/6455

摘要： The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex. The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases.

公开(公告)号：EP2810661A2

公开(公告)日：2014-12-10

申请号：EP14002542.0

申请日：2010-09-03

申请人： Curevac GmbH

发明人： Baumhof, Patrick ,  Schlake, Thomas

IPC分类号： A61K47/48

CPC分类号： A61K48/0041 ,  A61K47/60 ,  A61K47/6455

摘要： The present invention is directed to an inventive polymeric carrier molecule according to generic formula (I) and variations thereof, which allows for efficient transfection of nucleic acids into cells in vivo and in vitro, a polymeric carrier cargo complex formed by a nucleic acid and the inventive polymeric carrier molecule, but also to methods of preparation of this inventive polymeric carrier molecule and of the inventive polymeric carrier cargo complex. The present invention also provides methods of application and use of this inventive polymeric carrier molecule and the inventive polymeric carrier cargo complex as a medicament, for the treatment of various diseases, and in the preparation of a pharmaceutical composition for the treatment of such diseases.

摘要翻译： 本发明涉及根据通式（I）及其变体的本发明的聚合物载体分子，其允许核酸在体内和体外有效转染细胞，由核酸和 本发明的聚合物载体分子，而且还涉及本发明的聚合物载体分子和本发明的聚合物载体货物复合物的制备方法。 本发明还提供了本发明的聚合物载体分子和本发明的聚合物载体载体复合物作为药物的应用和用途的方法，用于治疗各种疾病以及用于治疗这些疾病的药物组合物的制备。

公开(公告)号：EP2796557A1

公开(公告)日：2014-10-29

申请号：EP14002182.5

申请日：2011-08-12

申请人： CureVac GmbH

发明人： Theß, Andreas ,  Schlake, Thomas ,  Probst, Jochen

IPC分类号： C12N15/67

CPC分类号： A61K48/0066 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/575 ,  C07K14/435 ,  C12N15/67

摘要： The present application describes a coding nucleic acid sequence, particularly a messenger RNA (mRNA), comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal and the use thereof for increasing the expression of an encoded protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine e.g. for the use in the treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, autoimmune diseases or genetic diseases, or in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal and an ex vivo and in vivo method.

摘要翻译： 本申请描述了一种编码核酸序列，特别是包含或用于增加所编码蛋白质的表达编码组蛋白茎环和聚（A）序列或聚腺苷酸化信号和使用它们的信使RNA（mRNA） ， 因此，光盘失去其用途的药物组合物的制备中，特别喜爱一个E.G.疫苗 在肿瘤和癌症疾病，心血管疾病，感染性疾病，自身免疫性疾病或遗传病，或在基因治疗的药物中的用途。 本发明进一步描述了在体外转录的方法，在体外使用核酸，其包含或编码为一个组蛋白茎环和聚（A）序列或聚腺苷酸化信号，并离体增加的蛋白质的表达的方法和 体内方法。