专利检索 ap:("Dana-Farber Cancer Institute, Inc." OR "Beth Israel Deaconess Medical Center, Inc." OR "Yeda Research AND Development Co. Ltd") AND inv:"GRAY, Nathanael, S." 第 1 页

1.

发明公开
INHIBITORS OF THE PEPTIDYL-PROLYL CIS/TRANS ISOMERASE (PIN1), COMBINATIONS AND USES THEREOF 审中-实审

公开(公告)号：EP4405395A1

公开(公告)日：2024-07-31

申请号：EP22873890.2

申请日：2022-09-23

申请人： Dana-Farber Cancer Institute, Inc. , Beth Israel Deaconess Medical Center, Inc. , Yeda Research and Development Co. Ltd

发明人： KE, Shizhong , WULF, Gerburg , ZHOU, Xiao, Zhen , LONDON, Nir , WEI, Wenyi , LU, Kun, Ping , GRAY, Nathanael, S. , NABET, Behnam

IPC分类号： C07K16/28 , A61K45/06 , A61P35/04 , C12N9/90 , A61K31/33

CPC分类号： A61P35/04 , A61K45/06 , C12Y207/11022 , C12Y502/01008 , A61K31/519 , A61K31/506 , A61K31/203 , A61K33/36 , A61K2039/50520130101 , C07K16/2818 , C07K2317/7620130101

2.

发明公开
INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND USES THEREOF 审中-公开

公开(公告)号：EP4164752A1

公开(公告)日：2023-04-19

申请号：EP21735521.3

申请日：2021-06-02

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. , ZHANG, Tinghu , KWIATKOWSKI, Nicholas, Paul , FAN, Mengyang , CHE, Jianwei , LU, Wenchao

IPC分类号： A61P35/00 , C07D213/64 , C07D233/64 , C07D237/08 , C07D239/26 , C07D239/34 , C07D257/04 , C07D271/10 , C07D277/28 , C07D401/04 , C07D403/04 , C07D405/12 , C07D513/04 , A61K31/505 , A61K31/41 , A61K31/4174 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/50

3.

发明公开
THE COMBINATION OF CYCLIN DEPENDENT KINASE 7 INHIBITOR AND IMMUNOTHERAPY FOR TREATMENT OF CANCER 审中-公开

公开(公告)号：EP4081527A1

公开(公告)日：2022-11-02

申请号：EP20908219.7

申请日：2020-12-16

申请人： Dana-Farber Cancer Institute, Inc. , New York University

发明人： GRAY, Nathanael, S. , WONG, Kwok-kin , ZHANG, Hua , ROSS, Camilla, Laulund Christensen

IPC分类号： C07D487/04 , A61P35/00 , A61K31/4162 , C07D487/10 , A61K31/454 , A61K45/06

4.

发明公开
DEGRADERS OF CYCLIN-DEPENDENT KINASE 12 (CDK12) AND USES THEREOF 审中-公开

公开(公告)号：EP3958861A1

公开(公告)日：2022-03-02

申请号：EP20795755.6

申请日：2020-04-23

申请人： Dana-Farber Cancer Institute, Inc.

发明人： CHE, Jianwei , GRAY, Nathanael, S. , ZHANG, Tinghu , JIANG, Baishan , GAO, Yang , KWIATKOWSKI, Nicholas, Paul

IPC分类号： A61K31/427 , A61K31/4523 , A61K31/454 , A61K38/05 , A61K47/54

5.

发明公开
BENZOTHIAZOLE DERIVATIVES AND 7-AZA-BENZOTHIAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF 审中-公开

公开(公告)号：EP3876939A1

公开(公告)日：2021-09-15

申请号：EP19882880.8

申请日：2019-11-07

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. , ZHANG, Tinghu , LIU, Yao , WEINSTOCK, David , LI, Loretta, Sze-mun , HAO, Mingfeng

IPC分类号： A61K31/496 , A61K31/426 , A61K31/428 , C07D277/66 , C07D277/68 , C07D277/82

6.

发明公开
DEGRADERS THAT TARGET PROTEINS VIA KEAP1 审中-公开

公开(公告)号：EP3823613A1

公开(公告)日：2021-05-26

申请号：EP19837280.7

申请日：2019-07-18

申请人： Dana Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. , ZHANG, Tinghu , FISCHER, Eric , DU, Guangyan , SAFAEE, Nozhat , HENNING, Nathaniel , DONOVAN, Katherine

IPC分类号： A61K31/41 , A61K31/4192 , A61K31/4439 , C07D249/18 , C07D401/02

7.

发明公开
USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS 审中-公开

公开(公告)号：EP3589284A1

公开(公告)日：2020-01-08

申请号：EP18760857.5

申请日：2018-02-28

申请人： The General Hospital Corporation , Dana-Farber Cancer Institute, Inc.

发明人： MURAKAMI, Ryo , FISHER, David, E. , MUJAHID, Nisma , GRAY, Nathanael, S. , LIANG, Yanke , CHOI, Hwan Geun

IPC分类号： A61K31/395 , A61K31/505 , A61K31/506

8.

发明公开
PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING PI3K-MEDIATED DISORDERS 审中-公开

公开(公告)号：EP3440084A1

公开(公告)日：2019-02-13

申请号：EP17779885.7

申请日：2017-04-07

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. , ZHANG, Tinghu , FERGUSON, Fleur, M. , ZHAO, Jean , NI, Jing

IPC分类号： C07D487/14 , C07D495/14 , C07D473/34

9.

发明公开
COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS 审中-公开
标题翻译：转录抑制剂与激酶抑制剂联用治疗

公开(公告)号：EP3307728A1

公开(公告)日：2018-04-18

申请号：EP16808476.2

申请日：2016-06-10

申请人： Dana Farber Cancer Institute, Inc.

发明人： HAMMERMAN, Peter , WONG, Kwok-kin , GRAY, Nathanael, S.

IPC分类号： C07D401/14 , A61K31/421

CPC分类号： A61K31/506 , A61K31/4162 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K31/69 , A61K45/06 , A61P35/00 , A61K2300/00

摘要： The present disclosure provides combination therapy of a transcription inhibitor and a kinase inhibitor. The combination of the transcription inhibitor and the kinase inhibitor may be useful in treating and/or preventing in a subject a proliferative disease, such as proliferative a disease that is resistant to the transcription inhibitor alone or the kinase inhibitor alone. In certain embodiments, the proliferative disease is a cancer. The combination of the transcription inhibitor and the kinase inhibitor is expected to be synergistic.

10.

发明授权
PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS 有权
标题翻译：嘧啶二氮杂酮激酶支架化合物和治疗疾病的方法

公开(公告)号：EP2379559B1

公开(公告)日：2017-10-25

申请号：EP10729389.6

申请日：2010-01-06

申请人： Dana-Farber Cancer Institute, Inc.

发明人： GRAY, Nathanael, S. , DENG, Xianming , KWIATKOWSKI, Nicholas, Paul

IPC分类号： C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D513/04 , A61P35/00 , A61P29/00 , A61K31/4985 , A61K31/519

CPC分类号： C07D513/04 , C07C2601/08 , C07C2601/14 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14

摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS 1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1,2,3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.