公开(公告)号：EP4405395A1

公开(公告)日：2024-07-31

申请号：EP22873890.2

申请日：2022-09-23

申请人： Dana-Farber Cancer Institute, Inc. ,  Beth Israel Deaconess Medical Center, Inc. ,  Yeda Research and Development Co. Ltd

发明人： KE, Shizhong ,  WULF, Gerburg ,  ZHOU, Xiao, Zhen ,  LONDON, Nir ,  WEI, Wenyi ,  LU, Kun, Ping ,  GRAY, Nathanael, S. ,  NABET, Behnam

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61P35/04 ,  C12N9/90 ,  A61K31/33

CPC分类号： A61P35/04 ,  A61K45/06 ,  C12Y207/11022 ,  C12Y502/01008 ,  A61K31/519 ,  A61K31/506 ,  A61K31/203 ,  A61K33/36 ,  A61K2039/50520130101 ,  C07K16/2818 ,  C07K2317/7620130101

公开(公告)号：EP2968548B1

公开(公告)日：2020-09-09

申请号：EP14768309.8

申请日：2014-03-14

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： LU, Kun, Ping ,  ZHOU, Xiao, Zhen

IPC分类号： C07K16/18 ,  A61P25/28

公开(公告)号：EP2858648B1

公开(公告)日：2018-08-22

申请号：EP13800857.8

申请日：2013-06-07

申请人： Beth Israel Deaconess Medical Center, Inc. ,  The United States of America as represented by the Secretary, Department of Health and Human Services

发明人： LU, Kun, Ping ,  BOXER, Matthew, Brian ,  DAVIS, Mindy Irene, Emily ,  PRAGANI, Rajan ,  SHEN, Min ,  SIMEONOV, Anton, Momtchilov ,  WEI, Shuo ,  ZHOU, Xiao, Zhen

IPC分类号： A61K31/473 ,  C12N9/90 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K31/5377 ,  A61K31/185 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/381 ,  A61K31/382 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/473 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

公开(公告)号：EP2858648A1

公开(公告)日：2015-04-15

申请号：EP13800857.8

申请日：2013-06-07

申请人： Beth Israel Deaconess Medical Center, Inc. ,  The United States of America as Represented by the Secretary, Department of Health and Human Services

发明人： LU, Kun, Ping ,  BOXER, Matthew, Brian ,  DAVIS, Mindy Irene, Emily ,  PRAGANI, Rajan ,  SHEN, Min ,  SIMEONOV, Anton, Momtchilov ,  WEI, Shuo ,  ZHOU, Xiao, Zhen

IPC分类号： A61K31/473 ,  C12N9/90

CPC分类号： A61K31/5377 ,  A61K31/185 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/381 ,  A61K31/382 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/473 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

摘要翻译： 本发明的特征在于用于抑制Pin1蛋白的组合物和方法，以及治疗以Pin1水平升高为特征的病症。

公开(公告)号：EP1771556A2

公开(公告)日：2007-04-11

申请号：EP05807006.1

申请日：2005-07-15

申请人： Vernalis PLC ,  Beth Israel Deaconess Medical Center, Inc.

发明人： LU, Kun, Ping ,  SOWADSKI, Janusz, M. ,  SUTO, Robert, K. ,  MCKEE, Timothy, D. ,  KIMZEY, Amy, L. ,  SUIZU, Futoshi

IPC分类号： C12N9/90 ,  C30B29/58 ,  C07K16/40 ,  C12Q1/533 ,  C12N15/11 ,  C12N15/61 ,  C12N1/21

CPC分类号： C12N9/90 ,  C07K2299/00 ,  Y02A90/24

摘要： This invention relates to methods of determining the prognosis of a subject with a Pin1 associated disorder by evaluating the levels of phosphorylated Pin1 in a biological sample. The invention also provides Pin1 polypeptides phosphorylated position 16, position 71, or both. The invention further relates to a crystal structure of a pPin1(71) polypeptide and a pPin1(16)(71) polypeptide. The invention also provides constitutively active mutants of Pin1 and modulators that are specific for the molecules. The invention further provides methods for determining if a subject is at risk of developing a Pin1 associated state by determining if a the subject has a mutation in Pin1 that renders the polypeptide constitutively active.

公开(公告)号：EP1631823A2

公开(公告)日：2006-03-08

申请号：EP04751521.8

申请日：2004-05-07

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： RYO, Akihide ,  LU, Kun, Ping

IPC分类号： G01N33/53 ,  G01N33/567

CPC分类号： C12N9/90 ,  C12N2310/14 ,  C12Y502/01008

摘要： The instant invention pertains to the discovery of two novel regulatory mechanisms of NF-kB. The instant invention demonstrates that NF-kB is regulated by PinI-catalyzed prolyl isomerization and ubiquitin-mediated proteolysis of p65. Accordingly, the instant invention provides methods for regulating NF-kB, and diseases and disorders associated with NF-kB. Further, the invention provides compositions capable of modulating the activity or expression of NF-kB, Pinl, and/or the proteolysis of p65.

公开(公告)号：EP2968548A2

公开(公告)日：2016-01-20

申请号：EP14768309.8

申请日：2014-03-14

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： LU, Kun, Ping ,  ZHOU, Xiao, Zhen

IPC分类号： A61K39/395

摘要： The present invention features methods and compositions for the generation and use of conformation-specific anti-bodies or fragments thereof.

摘要翻译： 本发明的特征在于用于产生和使用构象特异性抗体或其片段的方法和组合物。