公开(公告)号：EP1667714B1

公开(公告)日：2018-01-03

申请号：EP04784298.4

申请日：2004-09-17

申请人： Duke University ,  The University of Alabama at Birmingham Research Foundation ,  The Regents of the University of California

发明人： HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  SHAW, George, M. ,  KOTHE, Denise ,  LI, Ying Ying ,  DECKER, Julie ,  LIAO, Hua-Xin

IPC分类号： A61K39/21 ,  C07H21/04 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/4225 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

公开(公告)号：EP1667714A2

公开(公告)日：2006-06-14

申请号：EP04784298.4

申请日：2004-09-17

申请人： Duke University ,  The University of Alabama at Birmingham Research Foundation ,  The Regents of the University of California

发明人： HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  SHAW, George, M. ,  KOTHE, Denise ,  LI, Ying Ying ,  DECKER, Julie ,  LIAO, Hua-Xin

IPC分类号： A61K39/21 ,  C07H21/04 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/4225 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和广谱HIV原发分离株和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法，和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。

公开(公告)号：EP2318430A2

公开(公告)日：2011-05-11

申请号：EP09806982.6

申请日：2009-08-14

申请人： Los Alamos National Security, LLC ,  Beth Israel Deaconess Medical Center ,  Duke University ,  The University of Alabama at Birmingham Research Foundation

发明人： KORBER, Bette, T. ,  FISCHER, William ,  LETVIN, Norman ,  LIAO, Hua-xin ,  HAYNES, Barton, F. ,  HAHN, Beatrice, H.

IPC分类号： C07K14/155 ,  C12N15/49 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2740/16334

摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

摘要翻译： 本发明涉及马赛克进化枝M HIV-1 Env多肽和包含其的组合物。 本发明的多肽适用于诱导人体对HIV-1的免疫应答。

公开(公告)号：EP2129395A2

公开(公告)日：2009-12-09

申请号：EP08799657.5

申请日：2008-03-27

申请人： The Regents of the University of California ,  Duke University ,  THE UNIVERSITY OF ALABAMA AT BIRMINGHAM ,  UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： HAYNES, Barton, F. ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  BHATTACHARYA, Tanmoy ,  GNANAKARAN, Gnana, S. ,  GAO, Feng ,  SWANSTROM, Ron ,  SHAW, George

IPC分类号： A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.

公开(公告)号：EP1917040A2

公开(公告)日：2008-05-07

申请号：EP06802155.9

申请日：2006-08-23

申请人： The Regents of the University of California ,  Beth Israel Deaconess Medical Center ,  Duke University ,  University of Alabama at Birmingham Research Foundation

发明人： KORBER, Bette, T. ,  PERKINS, Simon ,  BHATTACHARYA, Tanmoy ,  FISCHER, William, M. ,  THEILER, James ,  LETVIN, Norman ,  HAYNES, Barton, F. ,  HAHN, Beatrice, H. ,  YUSIM, Karina ,  KUIKEN, Carla

IPC分类号： A61K48/00

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  C12N2740/16034

摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

公开(公告)号：EP3126502A1

公开(公告)日：2017-02-08

申请号：EP15772335.4

申请日：2015-03-31

申请人： Duke University ,  The Trustees of The University of Pennsylvania ,  Los Alamos National Security, LLC

发明人： HAYNES, Barton, F. ,  HAHN, Beatrice, H. ,  SHAW, George, M. ,  KORBER, Bette, T. ,  HRABER, Peter, T.

IPC分类号： C12N15/49 ,  C07K14/155 ,  A61K31/7088 ,  A61K39/21

CPC分类号： A61K31/7088 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/70 ,  C07K14/155 ,  C12N2740/16034

摘要： In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.

摘要翻译： 在某些方面，本发明提供包含CH848 HIV-1包膜的致突变组合物及其在受试者例如人受试者中诱导免疫应答的方法中的用途。

公开(公告)号：EP2895500A1

公开(公告)日：2015-07-22

申请号：EP13837551.4

申请日：2013-09-12

申请人： Duke University ,  Los Alamos National Security LLC ,  The Trustees Of The University Of Pennsylvania ,  Trustees of Boston University ,  The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services ,  The Board of Trustees of the Leland Stanford Junior University

发明人： HAYNES, Barton, F. ,  LIAO, Hua-Xin ,  LYNCH, Rebecca, M. ,  ZHOU, Tongqing ,  GAO, Feng ,  BOYD, Scott ,  SHAW, George, M. ,  HAHN, Beatrice, H. ,  KEPLER, Thomas, B. ,  KORBER, Bette, T. ,  KWONG, Peter ,  MASCOLA, John

IPC分类号： C07K14/155 ,  A61K39/12 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/57 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

摘要翻译： 本发明一般涉及HIV-1，特别涉及广泛中和HIV-1抗体和HIV-1免疫原，以及涉及使用此类免疫原以诱导产生广泛中和HIV-1抗体的方法 主题（例如，人）。

公开(公告)号：EP2542566A2

公开(公告)日：2013-01-09

申请号：EP11751024.8

申请日：2011-03-03

申请人： THE UAB RESEARCH FOUNDATION ,  Duke University ,  The Rockefeller University

发明人： SHAW, George, M. ,  HAHN, Beatrice, H. ,  LI, Hui ,  HAYNES, Barton, F. ,  MARKOWITZ, Martin

IPC分类号： C07K14/16 ,  C12N15/49 ,  C07K16/10 ,  A61K39/42 ,  C12N15/86 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K39/12 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16034

摘要： The present invention relates, in general, to HIV-1 and, in particular, to a molecular clone of HIV- 1. The invention further relates to methods of inducing an immune response to HIV-1 in a patient and to immunogens suitable for use in such methods. The invention also relates to anti-HIV-1 antibodies and to methods of using same to prevent or treat HIV-infection.