公开(公告)号：EP1667714A2

公开(公告)日：2006-06-14

申请号：EP04784298.4

申请日：2004-09-17

申请人： Duke University ,  The University of Alabama at Birmingham Research Foundation ,  The Regents of the University of California

发明人： HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  SHAW, George, M. ,  KOTHE, Denise ,  LI, Ying Ying ,  DECKER, Julie ,  LIAO, Hua-Xin

IPC分类号： A61K39/21 ,  C07H21/04 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/4225 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和广谱HIV原发分离株和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法，和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。

公开(公告)号：EP1667714B1

公开(公告)日：2018-01-03

申请号：EP04784298.4

申请日：2004-09-17

申请人： Duke University ,  The University of Alabama at Birmingham Research Foundation ,  The Regents of the University of California

发明人： HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  SHAW, George, M. ,  KOTHE, Denise ,  LI, Ying Ying ,  DECKER, Julie ,  LIAO, Hua-Xin

IPC分类号： A61K39/21 ,  C07H21/04 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/4225 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

公开(公告)号：EP2318430A2

公开(公告)日：2011-05-11

申请号：EP09806982.6

申请日：2009-08-14

申请人： Los Alamos National Security, LLC ,  Beth Israel Deaconess Medical Center ,  Duke University ,  The University of Alabama at Birmingham Research Foundation

发明人： KORBER, Bette, T. ,  FISCHER, William ,  LETVIN, Norman ,  LIAO, Hua-xin ,  HAYNES, Barton, F. ,  HAHN, Beatrice, H.

IPC分类号： C07K14/155 ,  C12N15/49 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2740/16334

摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

摘要翻译： 本发明涉及马赛克进化枝M HIV-1 Env多肽和包含其的组合物。 本发明的多肽适用于诱导人体对HIV-1的免疫应答。

公开(公告)号：EP1917040A2

公开(公告)日：2008-05-07

申请号：EP06802155.9

申请日：2006-08-23

申请人： The Regents of the University of California ,  Beth Israel Deaconess Medical Center ,  Duke University ,  University of Alabama at Birmingham Research Foundation

发明人： KORBER, Bette, T. ,  PERKINS, Simon ,  BHATTACHARYA, Tanmoy ,  FISCHER, William, M. ,  THEILER, James ,  LETVIN, Norman ,  HAYNES, Barton, F. ,  HAHN, Beatrice, H. ,  YUSIM, Karina ,  KUIKEN, Carla

IPC分类号： A61K48/00

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  C12N2740/16034

摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

公开(公告)号：EP2129395A2

公开(公告)日：2009-12-09

申请号：EP08799657.5

申请日：2008-03-27

申请人： The Regents of the University of California ,  Duke University ,  THE UNIVERSITY OF ALABAMA AT BIRMINGHAM ,  UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： HAYNES, Barton, F. ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  BHATTACHARYA, Tanmoy ,  GNANAKARAN, Gnana, S. ,  GAO, Feng ,  SWANSTROM, Ron ,  SHAW, George

IPC分类号： A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.

公开(公告)号：EP1601328A2

公开(公告)日：2005-12-07

申请号：EP04715002.4

申请日：2004-02-26

申请人： Duke University ,  The Regents of the University of California

发明人： HAYNES, Barton, F. ,  KORBER, Bette, T. ,  DE LORIMIER, Robert, M. ,  LIAO, Hua-Xin

IPC分类号： A61K6/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K2319/00 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  Y10S530/826

摘要： The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.

公开(公告)号：EP4415752A2

公开(公告)日：2024-08-21

申请号：EP22881744.1

申请日：2022-10-12

申请人： Duke University ,  The Trustees of the University of Pennsylvania ,  Korber, Bette, T. ,  Wagh, Kshitij, G. ,  Shaw, George, M. ,  Weissman, Drew ,  Alameh, Mohamad-Gabriel

发明人： HAYNES, Barton, F. ,  SAUNDERS, Kevin, O. ,  HAHN, Beatrice ,  DING, Wenge ,  RUSSELL, Ronnie, M. ,  KORBER, Bette, T. ,  WAGH, Kshitij, G. ,  SHAW, George, M. ,  WEISSMAN, Drew ,  ALAMEH, Mohamad-Gabriel

IPC分类号： A61K39/21 ,  A61P31/18 ,  C07K14/16 ,  C12N15/49 ,  A61K9/127 ,  A61K39/295 ,  C12N15/85

CPC分类号： A61K39/12 ,  C12N2740/1613420130101 ,  A61K2039/57520130101 ,  A61K2039/5320130101 ,  C07K14/005 ,  C12N2740/1612220130101

公开(公告)号：EP4284427A1

公开(公告)日：2023-12-06

申请号：EP22746696.8

申请日：2022-01-28

申请人： Duke University

发明人： HENDERSON, Rory ,  HAYNES, Barton, F.

IPC分类号： A61K39/21 ,  C07K14/005 ,  C12N7/00 ,  A61P31/18 ,  A61K39/39

公开(公告)号：EP2739300B1

公开(公告)日：2019-06-19

申请号：EP12807743.5

申请日：2012-07-05

申请人： Duke University ,  Children's Medical Center Corporation ,  The Government of The US, as Represented by The Secretary of the Army, on behalf of Walter Reed Army Institute of Research

发明人： KIM, Jerome ,  HARRISON, Stephen ,  HAYNES, Barton, F. ,  TOMARAS, Georgia, D. ,  MICHAEL, Nelson

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K39/245 ,  A61K48/00 ,  A61P37/00 ,  A61P31/00 ,  A61K39/21 ,  C07K14/005

公开(公告)号：EP3160986A2

公开(公告)日：2017-05-03

申请号：EP15812422.2

申请日：2015-06-25

申请人： Duke University

发明人： HAYNES, Barton, F. ,  LIAO, Hua-Xin ,  ALAM, S., Munir

IPC分类号： C07K14/16 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  C07K14/005 ,  C12N2740/16071 ,  C12N2740/16122 ,  C12N2740/16134

摘要： In certain aspects the invention provides HIV-1 engineered envelope proteins and their uses. The engineered envelopes comprise a sequence that prevents cleavage of the envelope associated with recombinant expression in a cell line, and N-terminal deletion which improves envelope expression as a monomer.

摘要翻译： 在某些方面，本发明提供了HIV-1工程包膜蛋白及其用途。 工程包膜包含防止与细胞系中的重组表达相关的包膜的切割的序列和改善作为单体的包膜表达的N端缺失。