公开(公告)号：EP1572724A2

公开(公告)日：2005-09-14

申请号：EP03711418.8

申请日：2003-03-03

申请人： Dyax Corp. ,  BRACCO International B.V.

发明人： SATO, Aaron, K. ,  SEXTON, Daniel, J. ,  LADNER, Robert, C. ,  DRANSFIELD, Daniel, T. ,  SWENSON, Rolf, E. ,  MARINELLI, Edmund, R. ,  RAMALINGAM, Kondareddiar ,  NUNN, Adrian, D. ,  VON WRONSKI, Mathew, A. ,  SHRIVASTAVA, Ajay ,  POCHON, Sibylle ,  BUSSAT, Philippe ,  ARBOGAST, Christophe ,  PILLAI, Radhakrishna ,  FAN, Hong ,  LINDER, Karen, E. ,  SONG, Bo ,  NANJAPPAN, Palaniappa

IPC分类号： C07K7/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K49/223 ,  A61K51/088 ,  C07K14/001 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e . g ., having a K D

公开(公告)号：EP1531791B1

公开(公告)日：2010-08-11

申请号：EP03757339.1

申请日：2003-06-06

申请人： Dyax Corp.

发明人： LADNER, Robert, C. ,  LEY, Arthur, C. ,  HIRANI, Shirish ,  WILLIAMS, Anthony

IPC分类号： A61P29/00 ,  A61P7/00 ,  A61K38/55

CPC分类号： A61K38/57 ,  A61K9/0019 ,  A61K38/55 ,  C12N9/6445

摘要： Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g., coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.

公开(公告)号：EP0907887A1

公开(公告)日：1999-04-14

申请号：EP97916844.0

申请日：1997-03-20

申请人： Dyax Corp.

发明人： MACLENNAN, John, M. ,  LADNER, Robert, C.

IPC分类号： C12N9 ,  B01J20 ,  C07K1 ,  C07K7 ,  C07K14 ,  C07K17 ,  C12N15 ,  C40B30 ,  C40B40 ,  G01N30 ,  G01N33

CPC分类号： C40B30/04 ,  C07K1/047 ,  C07K14/001 ,  C07K14/811 ,  C07K14/8114 ,  C07K2319/00 ,  C12N9/6459 ,  C12N15/1037 ,  C12Y304/21069 ,  C40B40/02 ,  G01N33/6845

摘要： A method is disclosed for obtaining highly specific and tailored ligands suitable for purifying a particular product target or for eliminating particular target impurities in a feed stream. Engineered affinity ligands according to the invention will bind a target with high specificity at a preselected binding condition and release the target at a preselected elution condition. The ligands are isolated by contacting a target with a multiplicity of polypeptides derived through variegation of the structure of a candidate binding domain, the variants (or analogues) including polypeptides favoring binding to the target under desired binding conditions and release from the target under elution conditions, where the binding and elution conditions differ according to one or more parameters, such as pH, temperature, concentration of salt or volume % of an organic solvent.

公开(公告)号：EP1276855B1

公开(公告)日：2012-10-24

申请号：EP01927108.9

申请日：2001-04-17

申请人： Dyax Corp.

发明人： LADNER, Robert, C. ,  COHEN, Edward, Hirsch ,  NASTRI, Horacio, Gabriel ,  ROOKEY, Kristin, L. ,  HOET, Rene

IPC分类号： C12N15/10 ,  C12N15/66 ,  C40B40/02

CPC分类号： C12N15/1093 ,  C12N15/10 ,  C12N15/1037 ,  C12N15/66 ,  C40B40/02

公开(公告)号：EP1663279A2

公开(公告)日：2006-06-07

申请号：EP04782687.0

申请日：2004-08-30

申请人： Dyax Corp. ,  Nektar Therapeutics

发明人： LADNER, Robert, C. ,  SATO, Aaron, K. ,  AMARAL, Michelle ,  BOSSARD, Mary, J. ,  ROBERTS, Michael, J. ,  ZHANG, Yan ,  LEY, Arthur, C.

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N9/00 ,  C12N9/66

CPC分类号： C07K14/8114 ,  A61K38/00 ,  A61K47/60 ,  A61K49/0002

摘要： DX-890 inhibits elastase. DX-890 can be attached a single polyethylene glycol moiety. The polyethylene glycol is at least 18 kDa in molecular weight and is attached to the polypeptide by a single covalent bond to the N-terminus of the polypeptide.

公开(公告)号：EP1603935A2

公开(公告)日：2005-12-14

申请号：EP04716901.6

申请日：2004-03-03

申请人： Dyax Corp. ,  BRACCO International B.V.

发明人： SATO, Aaron, K. ,  DRANSFIELD, Daniel, T. ,  LADNER, Robert, C. ,  THOMAS, Regi ,  NANJAPPAN, Palaniappa

IPC分类号： C07K1/00

CPC分类号： C07K7/08 ,  A61K47/543 ,  A61K47/60 ,  A61K47/665 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/08 ,  B82Y5/00 ,  C07K14/00 ,  C07K14/4753

摘要： A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.

公开(公告)号：EP0904541A1

公开(公告)日：1999-03-31

申请号：EP97918488.0

申请日：1997-03-20

申请人： Dyax Corp.

发明人： MACLENNAN, John, M. ,  LADNER, Robert, C. ,  RANSOHOFF, Thomas, C.

IPC分类号： C12N9 ,  B01J20 ,  C07K1 ,  C07K7 ,  C07K14 ,  C07K17 ,  C12N15 ,  C40B30 ,  C40B40 ,  G01N30 ,  G01N33

CPC分类号： C40B30/04 ,  C07K1/047 ,  C07K14/001 ,  C07K14/811 ,  C07K14/8114 ,  C07K2319/00 ,  C12N9/6459 ,  C12N15/1037 ,  C12Y304/21069 ,  C40B40/02 ,  G01N33/6845

摘要： A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed. Also disclosed are methods whereby additional ligands having desirable preselected binding and release (elution) characteristics may be isolated, permitting the development of tailored ligands to meet the purification problems presented by any particular feed stream containing tPA.

公开(公告)号：EP2478136A2

公开(公告)日：2012-07-25

申请号：EP10816294.2

申请日：2010-09-14

申请人： Dyax Corp.

发明人： LADNER, Robert, C.

IPC分类号： C40B40/08

CPC分类号： C07K16/005 ,  C07K2317/21 ,  C07K2317/565

摘要： Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long. Libraries encoding antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.

公开(公告)号：EP1587944A1

公开(公告)日：2005-10-26

申请号：EP03770325.3

申请日：2003-09-11

申请人： Dyax Corp. ,  BRACCO International B.V.

发明人： SATO, Aaron, K. ,  SEXTON, Daniel, J. ,  DRANSFIELD, Daniel, T. ,  LADNER, Robert, C. ,  ARBOGAST, Christophe ,  BUSSAT, Philippe ,  FAN, Hong ,  KHURANA, Sudha ,  LINDER, Karen, E. ,  MARINELLI, Edmund, R. ,  NANJAPPAN, Palaniappa ,  NUNN, Adrian ,  PILLAI, Radhakrishna ,  POCHON, Sibylle ,  RAMALINGAM, Kondareddiar ,  SHRIVASTAVA, Ajay ,  SONG, Bo ,  SWENSON, Rolf E. ,  VON WRONSKI, Mathew A.

IPC分类号： C12Q1/00 ,  A61K48/00

CPC分类号： A61K49/221 ,  A61K38/00 ,  A61K47/62 ,  A61K49/223 ,  A61K51/088 ,  C07K7/08 ,  C07K14/001 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

公开(公告)号：EP2245153A1

公开(公告)日：2010-11-03

申请号：EP09710404.6

申请日：2009-02-13

申请人： Dyax Corp.

发明人： LADNER, Robert, C.

IPC分类号： C12N15/00 ,  C12N15/63

CPC分类号： C12N15/1037

摘要： Provided are improved methods for providing specific binding pairs (SBPs). The methods enable production of libraries of SBP members using both a large population of one member of the SBPs and a smaller, preselected population of the other member of the SBPs having affinity for a preselected target.