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1.发明授权4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效WITH A 4-氨基苯丙氨酸LINKS，血液白细胞抑制其VLA-4介导的粘附
公开(公告)号：EP1001974B1
公开(公告)日：2006-05-24
申请号：EP98937049.9
申请日：1998-07-30
申请人： ELAN PHARMACEUTICALS, INC. , Wyeth
发明人： ASHWELL, Susan , GRANT, Francine, S. , KONRADI, Andrei, W. , KREFT, Anthony , LOMBARDO, Louis, John , PLEISS, Michael, A. , SARANTAKIS, Dimitrios , SEMKO, Christopher, M. , THORSETT, Eugene, D.
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06165
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g, human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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2.发明公开FUSED RING HETEROARYL AND HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 审中-公开稠合杂芳和杂环化合物BY VLA-4介导的白细胞粘附INHIBIT
公开(公告)号：EP1147091A2
公开(公告)日：2001-10-24
申请号：EP00903379.6
申请日：2000-01-21
IPC分类号： C07D235/30 , C07D277/82 , C07D263/58 , C07D239/94 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/517 , A61P3/00 , A61P7/00 , A61P19/00 , A61P25/00
CPC分类号： C07D263/58 , C07D235/30 , C07D239/94 , C07D239/95 , C07D277/82
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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3.发明授权
公开(公告)号：EP1144364B1
公开(公告)日：2005-07-13
申请号：EP00911619.5
申请日：2000-01-21
IPC分类号： C07C233/63 , A61K31/16
CPC分类号： C07C233/84 , C07C233/63 , C07C233/85 , C07C233/87 , C07C237/22 , C07C255/60 , C07C271/22 , C07C271/34 , C07C271/42 , C07C271/44 , C07C275/16 , C07C275/18 , C07C275/20 , C07C275/24 , C07C2601/14 , C07C2603/74 , C07D213/55 , C07D213/64 , C07D213/80 , C07D213/89 , C07D239/52 , C07D239/54 , C07D261/08 , C07D277/48 , C07D295/15 , C07D295/205 , C07D453/02
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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4.发明公开SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效取代的苯丙氨酸衍生物，血液白细胞抑制其VLA-4介导的粘附
公开(公告)号：EP1001972A1
公开(公告)日：2000-05-24
申请号：EP98937990.4
申请日：1998-07-30
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , SARANTAKIS, Dimitrios , PLEISS, Michael, A. , LOMBARDO, Louis, John , KREFT, Anthony , KONRADI, Andrei, W. , GRANT, Francine, S. , DRESSEN, Darren, B. , DAPPEN, Michael, S. , BAUDY, Reinhardt, Bernhard , ASHWELL, Susan
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06165
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds are also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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5.发明公开
公开(公告)号：EP0994895A1
公开(公告)日：2000-04-26
申请号：EP98937991.2
申请日：1998-07-30
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , PLEISS, Michael, A. , KONRADI, Andrei, W. , GRANT, Francine, S. , DRESSEN, Darren, B. , BAUDY, Reinhardt, Bernhard
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/06078 , C07K5/06165
摘要： Diclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthristis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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公开(公告)号：EP1144388B1
公开(公告)日：2010-01-13
申请号：EP00913245.7
申请日：2000-01-21
申请人： ELAN PHARMACEUTICALS, INC. , Wyeth
发明人： KONRADI, Andrei , PLEISS, Michael, A. , THORSETT, Eugene, D. , ASHWELL, Susan , WELMAKER, Gregory, S. , KREFT, Anthony , SARANTAKIS, Dimitrios , DRESSEN, Darren, B. , GRANT, Francine, S. , SEMKO, Christopher , XU, Ying-Zi
IPC分类号： C07D239/42 , A61K31/505 , A61P7/00 , C07D401/12 , A61K31/495 , C07D405/12 , C07D409/12 , C07D285/10 , A61K31/41 , C07D417/12
CPC分类号： A61K31/425 , A61K31/41 , A61K31/427 , A61K31/433 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/54 , C07D211/58 , C07D213/74 , C07D213/76 , C07D233/88 , C07D239/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/52 , C07D241/20 , C07D249/06 , C07D251/18 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/54 , C07D257/06 , C07D285/06 , C07D285/10 , C07D333/36 , C07D333/48 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , Y02A50/463 , A61K2300/00
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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7.发明公开COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS 审中-公开使用再生剂治疗和治疗脱髓鞘疾病和麻痹的组合物
公开(公告)号：EP1592387A2
公开(公告)日：2005-11-09
申请号：EP04705270.9
申请日：2004-01-26
发明人： KARLIK, Steve, J. , PLEISS, Michael, A. , KONRADI, Andrei, W. , GRANT, Francine, S. , SEMKO, Christopher, M. , DRESSEN, Daren , MESSERSMITH, Elizabeth , FREEDMAN, Stephen , YEDNOCK, Ted
IPC分类号： A61K6/00
CPC分类号： A61K45/06 , A61K31/10 , A61K31/16 , A61K31/185 , A61K31/195 , A61K31/21 , A61K31/496 , C07D417/14 , A61K2300/00
摘要： The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.
摘要翻译： 本申请提供了用于在有需要的受试者中抑制脱髓鞘，促进髓鞘再生和/或治疗瘫痪的方法和组合物。 优选地，此类组合物包含免疫球蛋白（例如抗体，抗体片段和重组产生的抗体或片段），多肽（例如整联蛋白的配体蛋白的可溶形式）和小分子，其当以有效量施用时抑制脱髓鞘和/ 或促进患者的髓鞘再生。 本文所述的组合物和方法还可以使用其他用于减轻与脱髓鞘相关的病症和疾病的抗炎剂。
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8.发明公开SULFONYLATED DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 失效磺酰化的二肽血液白细胞抑制其VLA-4介导的粘附
公开(公告)号：EP0994896A1
公开(公告)日：2000-04-26
申请号：EP98939871.4
申请日：1998-07-31
发明人： THORSETT, Eugene, D. , SEMKO, Christopher, M. , PLEISS, Michael, A. , KREFT, Anthony , KONRADI, Andrei, W. , GRANT, Francine, S. , BAUDY, Reinhardt, Bernhard , SARANTAKIS, Dimitrios
CPC分类号： C07K5/06165 , A61K38/00 , C07K5/06139 , C07K5/06191
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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9.发明公开COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS 审中-公开组成并ENTMYELINIERENDEN疾病方面，因资金管理的REMYELINIERENDEN治疗和瘫痪
公开(公告)号：EP1592386A2
公开(公告)日：2005-11-09
申请号：EP04705266.7
申请日：2004-01-26
发明人： KARLIK, Steve, J. , PLEISS, Michael, A. , KONRADI, Andrei, W. , GRANT, Francine, S. , SEMKO, Christopher, M. , DRESSEN, Daren , MESSERSMITH, Elizabeth , FREEDMAN, Stephen , YEDNOCK, Ted
IPC分类号： A61K6/00
CPC分类号： A61K45/06 , A61K31/10 , A61K31/16 , A61K31/185 , A61K31/195 , A61K31/21 , A61K31/496 , C07D417/14 , A61K2300/00
摘要： The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.
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10.发明公开MULTICYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 有权MULTIZYKLISCHE VERBINDUNGEN ZUR HEMMUNG DER DURCH VLA-4 VERMITTELTENLEUKOZYTENADHÄSION
公开(公告)号：EP1144364A2
公开(公告)日：2001-10-17
申请号：EP00911619.5
申请日：2000-01-21
IPC分类号： C07C233/63 , A61K31/16
CPC分类号： C07C233/84 , C07C233/63 , C07C233/85 , C07C233/87 , C07C237/22 , C07C255/60 , C07C271/22 , C07C271/34 , C07C271/42 , C07C271/44 , C07C275/16 , C07C275/18 , C07C275/20 , C07C275/24 , C07C2601/14 , C07C2603/74 , C07D213/55 , C07D213/64 , C07D213/80 , C07D213/89 , C07D239/52 , C07D239/54 , C07D261/08 , C07D277/48 , C07D295/15 , C07D295/205 , C07D453/02
摘要： Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
摘要翻译： 公开了结合VLA-4的化合物。 这些化合物中的某些也抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。 这样的化合物可用于治疗哺乳动物患者例如人类例如哮喘，阿尔茨海默氏病，动脉粥样硬化，艾滋病痴呆，糖尿病，炎性肠病，类风湿性关节炎，组织移植，肿瘤转移和心肌缺血等炎性疾病。 化合物也可以用于治疗炎性脑疾病如多发性硬化症。
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