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公开(公告)号：EP0938310A1
公开(公告)日：1999-09-01
申请号：EP97928660.0
申请日：1997-06-05
发明人： JUNGHEIM, Louis, N. , MILLER, Shawn, C. , SPITZER, Wayne, A. , TEBBE, Mark, J. , VICTOR, Frantz
CPC分类号： C07D235/30
摘要： The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus and flaviviruses such as hepatitis C and bovine diarrheal virus.
摘要翻译： 本申请提供了抑制小核糖核酸病毒如鼻病毒，肠道病毒，脊髓灰质炎病毒，A和B组的柯萨奇病毒，回声病毒和门戈病毒以及黄病毒如丙型肝炎和牛腹泻病毒的生长的一系列苯并咪唑化合物。
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公开(公告)号：EP0914120A1
公开(公告)日：1999-05-12
申请号：EP97927737.0
申请日：1997-06-05
发明人： JUNGHEIM, Louis, N. , MILLER, Shawn, C. , SPITZER, Wayne, A. , TEBBE, Mark, J. , VICTOR, Frantz
CPC分类号： C07D409/12 , C07D235/30
摘要： The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus and flaviviruses such as hepatitis C and bovine diarrheal virus.
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公开(公告)号：EP1027051A1
公开(公告)日：2000-08-16
申请号：EP98922073.6
申请日：1998-04-30
发明人： CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , PALKOWITZ, Alan, D. , RICHETT, Michael, E. , SALL, Daniel, Jon , SMITH, Gerald, Floyd , TAKEUCHI, Kumiko , ZHANG, Minsheng
IPC分类号： A61K31/445 , A61K31/38
CPC分类号： C07D333/58 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D333/56 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of defined compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及如本文所定义的新的式（I）化合物（及其药学上可接受的盐），其制备方法和中间体，包含式（I）的新化合物的药物制剂以及式 （I）作为凝血酶抑制剂。
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公开(公告)号：EP0862430A1
公开(公告)日：1998-09-09
申请号：EP96917155.0
申请日：1996-06-05
发明人： MILLER, Shawn, C. , VICTOR, Frantz , SATTELBERG, Thomas, R., S. , SPITZER, Wayne, A. , TEBBE, Mark, J.
CPC分类号： C07D235/30
摘要： The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, cardioviruses, polioviruses, coxsachieviruses of the A and B groups, echo virus and Mengo virus. Such compounds are also useful as intermediates for preparing additional benzimidazole antiviral compounds.
摘要翻译： 本申请提供了一系列抑制小核糖核酸病毒（例如鼻病毒，肠道病毒，心脏病毒，脊髓灰质炎病毒，A和B组的柯萨奇病毒，回声病毒和门戈病毒）生长的苯并咪唑化合物。 这些化合物也可用作制备其他苯并咪唑抗病毒化合物的中间体。
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公开(公告)号：EP1027051B1
公开(公告)日：2005-01-05
申请号：EP98922073.6
申请日：1998-04-30
发明人： CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , PALKOWITZ, Alan, D. , RICHETT, Michael, E. , SALL, Daniel, Jon , SMITH, Gerald, Floyd , TAKEUCHI, Kumiko , ZHANG, Minsheng
IPC分类号： A61K31/445 , A61K31/38 , A61K31/40 , C07D409/10
CPC分类号： C07D333/58 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D333/56 , C07D409/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP1019047B1
公开(公告)日：2003-11-05
申请号：EP98920057.1
申请日：1998-04-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , MULLANEY, Jeffrey, T. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , WILEY, Michael, R. , ZHANG, Minsheng
IPC分类号： A61K31/415 , A61K31/41 , C07D235/18 , A61P7/02
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
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公开(公告)号：EP1019047A1
公开(公告)日：2000-07-19
申请号：EP98920057.1
申请日：1998-04-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , MULLANEY, Jeffrey, T. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , WILEY, Michael, R. , ZHANG, Minsheng
IPC分类号： A61K31/415 , A61K31/41
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
摘要： This application relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及如本文所定义的新的式（I）化合物及其药学上可接受的盐，其制备方法和中间体，包含式（I）的新化合物的药物制剂，以及式 I）作为凝血酶抑制剂。
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