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公开(公告)号：EP0963370A1
公开(公告)日：1999-12-15
申请号：EP97952325.0
申请日：1997-12-08
发明人： FISHER, Matthew, J. , FRANCISKOVICH, Jeffry, Bernard , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , SCARBOROUGH, Robert, M. , SMYTH, Mark , SU, Ting
CPC分类号： C07C311/06 , C07C311/19 , C07C2601/14 , C07D211/62
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
摘要翻译： 公开了与哺乳动物整联蛋白相关的新化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗血栓形成或再狭窄病症。
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2.发明授权SPIRO COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION 失效螺环化合物作为抑制剂纤维蛋白原依赖性血小板聚集
公开(公告)号：EP0854869B1
公开(公告)日：2004-08-25
申请号：EP96936093.2
申请日：1996-09-27
发明人： FISHER, Matthew, J. , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , MULLANEY, Jeffrey, T. , PAAL, Michael , RÜHTER, Gerd , RUTERBORIES, Kenneth, J. , SCARBOROUGH, Robert, M. , SCHOTTEN, Theo , STENZEL, Wolfgang
IPC分类号： C07D221/20 , A61K31/435 , C07D498/10 , C07D471/10 , C07D401/06 , C07D263/52 , A61K31/42
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
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3.发明公开SPIRO COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION 失效螺环化合物作为抑制剂纤维蛋白原依赖性血小板聚集
公开(公告)号：EP0854869A1
公开(公告)日：1998-07-29
申请号：EP96936093.0
申请日：1996-09-27
发明人： FISHER, Matthew, J. , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , MULLANEY, Jeffrey, T. , PAAL, Michael , RÜHTER, Gerd , RUTERBORIES, Kenneth, J. , SCARBOROUGH, Robert, M. , SCHOTTEN, Theo , STENZEL, Wolfgang
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要： This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
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公开(公告)号：EP1027051A1
公开(公告)日：2000-08-16
申请号：EP98922073.6
申请日：1998-04-30
发明人： CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , PALKOWITZ, Alan, D. , RICHETT, Michael, E. , SALL, Daniel, Jon , SMITH, Gerald, Floyd , TAKEUCHI, Kumiko , ZHANG, Minsheng
IPC分类号： A61K31/445 , A61K31/38
CPC分类号： C07D333/58 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D333/56 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of defined compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及如本文所定义的新的式（I）化合物（及其药学上可接受的盐），其制备方法和中间体，包含式（I）的新化合物的药物制剂以及式 （I）作为凝血酶抑制剂。
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公开(公告)号：EP1027051B1
公开(公告)日：2005-01-05
申请号：EP98922073.6
申请日：1998-04-30
发明人： CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , PALKOWITZ, Alan, D. , RICHETT, Michael, E. , SALL, Daniel, Jon , SMITH, Gerald, Floyd , TAKEUCHI, Kumiko , ZHANG, Minsheng
IPC分类号： A61K31/445 , A61K31/38 , A61K31/40 , C07D409/10
CPC分类号： C07D333/58 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D333/56 , C07D409/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP1019047B1
公开(公告)日：2003-11-05
申请号：EP98920057.1
申请日：1998-04-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , MULLANEY, Jeffrey, T. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , WILEY, Michael, R. , ZHANG, Minsheng
IPC分类号： A61K31/415 , A61K31/41 , C07D235/18 , A61P7/02
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
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公开(公告)号：EP0963370B1
公开(公告)日：2003-03-19
申请号：EP97952325.5
申请日：1997-12-08
发明人： FISHER, Matthew, J. , FRANCISKOVICH, Jeffry, Bernard , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , SCARBOROUGH, Robert, M. , SMYTH, Mark , SU, Ting
IPC分类号： C07C311/00 , C07D211/04 , A61K31/18 , A61K31/445
CPC分类号： C07C311/06 , C07C311/19 , C07C2601/14 , C07D211/62
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公开(公告)号：EP1019047A1
公开(公告)日：2000-07-19
申请号：EP98920057.1
申请日：1998-04-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , MULLANEY, Jeffrey, T. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , WILEY, Michael, R. , ZHANG, Minsheng
IPC分类号： A61K31/415 , A61K31/41
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
摘要： This application relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及如本文所定义的新的式（I）化合物及其药学上可接受的盐，其制备方法和中间体，包含式（I）的新化合物的药物制剂，以及式 I）作为凝血酶抑制剂。
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