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公开(公告)号：EP0980367A1
公开(公告)日：2000-02-23
申请号：EP98920094.4
申请日：1998-04-30
发明人： BACH, Nicholas, J. , BASTIAN, Jolie, A. , CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , PALKOWITZ, David, A. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , ZHANG, Minsheng
IPC分类号： C07D409/14
CPC分类号： C07D333/58 , C07D333/56 , C07D333/60 , C07D409/10 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及如本文所定义的新的式（I）化合物（及其药学上可接受的盐），其制备方法和中间体，包含式（I）的新化合物的药物制剂，以及式 （I）作为凝血酶抑制剂。
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公开(公告)号：EP0863755A1
公开(公告)日：1998-09-16
申请号：EP96940354.0
申请日：1996-10-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay, Y. , DENNEY, Michael, L. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , KOHN, Todd, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , PALKOWITZ, Alan, D. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , ZHANG, Minsheng
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula (I) as defined herein. It also provides novel compounds of formula (I), processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula (I).
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公开(公告)号：EP0863755B1
公开(公告)日：2004-12-15
申请号：EP96940354.2
申请日：1996-10-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay, Y. , DENNEY, Michael, L. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , KOHN, Todd, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , PALKOWITZ, Alan, D. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , ZHANG, Minsheng
IPC分类号： A61K31/34 , A61K31/38 , A61K31/40 , A61K31/42 , A61K31/395 , A61K31/425 , A61K31/435 , A61K31/495 , C07D211/06 , C07D241/02 , A61K31/44 , A61K31/445 , A61P7/02
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
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公开(公告)号：EP1019047B1
公开(公告)日：2003-11-05
申请号：EP98920057.1
申请日：1998-04-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , MULLANEY, Jeffrey, T. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , WILEY, Michael, R. , ZHANG, Minsheng
IPC分类号： A61K31/415 , A61K31/41 , C07D235/18 , A61P7/02
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
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公开(公告)号：EP1019047A1
公开(公告)日：2000-07-19
申请号：EP98920057.1
申请日：1998-04-30
发明人： BASTIAN, Jolie, A. , CHIRGADZE, Nickolay Y. , DENNEY, Michael, L. , FISHER, Matthew, J. , FOGLESONG, Robert, J. , HARPER, Richard, W. , JOHNSON, Mary, G. , KLIMKOWSKI, Valentine, J. , LIN, Ho-Shen , LYNCH, Michael, P. , MCCOWAN, Jefferson, R. , MILLER, Shawn, C. , MULLANEY, Jeffrey, T. , RICHETT, Michael, E. , SALL, Daniel, J. , SMITH, Gerald, F. , TAKEUCHI, Kumiko , TINSLEY, Jennifer, M. , WILEY, Michael, R. , ZHANG, Minsheng
IPC分类号： A61K31/415 , A61K31/41
CPC分类号： C07D231/12 , A61K31/4184 , A61K31/4196 , A61K31/497 , C07D233/56 , C07D235/18 , C07D249/08 , C07D403/12
摘要： This application relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.
摘要翻译： 本申请涉及如本文所定义的新的式（I）化合物及其药学上可接受的盐，其制备方法和中间体，包含式（I）的新化合物的药物制剂，以及式 I）作为凝血酶抑制剂。
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