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公开(公告)号:EP1511740A1
公开(公告)日:2005-03-09
申请号:EP03728782.8
申请日:2003-05-22
发明人: DAHNKE, Karl, Robert , GAJEWSKI, Robert, Peter , JONES, Charles, David , LINEBARGER, Jared, Harris , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , SIMARD, Todd, Parker , YEE, Ying, Kwong , BUNEL, Emilio, Enrique , STITES, Ryan, Edward
IPC分类号: C07D333/38 , C07D333/16 , C07D333/18 , C07D333/22 , C07D409/12 , C07D409/06 , C07D333/34 , C07D413/04 , C07D409/04 , A61K31/381 , A61K31/401 , A61K31/41 , A61K31/4245 , A61P19/10
CPC分类号: C07F9/655345 , C07D333/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12 , C07D413/04
摘要: The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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公开(公告)号:EP1511740B1
公开(公告)日:2009-07-08
申请号:EP03728782.8
申请日:2003-05-22
发明人: DAHNKE, Karl, Robert , GAJEWSKI, Robert, Peter , JONES, Charles, David , LINEBARGER, Jared, Harris , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , SIMARD, Todd, Parker , YEE, Ying, Kwong , BUNEL, Emilio, Enrique , STITES, Ryan, Edward
IPC分类号: C07D333/38 , C07D333/16 , C07D333/18 , C07D333/22 , C07D409/12 , C07D409/06 , C07D333/34 , C07D413/04 , C07D409/04 , A61K31/381 , A61K31/401 , A61K31/41 , A61K31/4245 , A61P19/10
CPC分类号: C07F9/655345 , C07D333/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12 , C07D413/04
摘要: The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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