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公开(公告)号：EP0963370A1
公开(公告)日：1999-12-15
申请号：EP97952325.0
申请日：1997-12-08
发明人： FISHER, Matthew, J. , FRANCISKOVICH, Jeffry, Bernard , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , SCARBOROUGH, Robert, M. , SMYTH, Mark , SU, Ting
CPC分类号： C07C311/06 , C07C311/19 , C07C2601/14 , C07D211/62
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
摘要翻译： 公开了与哺乳动物整联蛋白相关的新化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗血栓形成或再狭窄病症。
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2.发明公开SPIRO COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION 失效螺环化合物作为抑制剂纤维蛋白原依赖性血小板聚集
公开(公告)号：EP0854869A1
公开(公告)日：1998-07-29
申请号：EP96936093.0
申请日：1996-09-27
发明人： FISHER, Matthew, J. , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , MULLANEY, Jeffrey, T. , PAAL, Michael , RÜHTER, Gerd , RUTERBORIES, Kenneth, J. , SCARBOROUGH, Robert, M. , SCHOTTEN, Theo , STENZEL, Wolfgang
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要： This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
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3.发明授权SPIRO COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION 失效螺环化合物作为抑制剂纤维蛋白原依赖性血小板聚集
公开(公告)号：EP0854869B1
公开(公告)日：2004-08-25
申请号：EP96936093.2
申请日：1996-09-27
发明人： FISHER, Matthew, J. , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , MULLANEY, Jeffrey, T. , PAAL, Michael , RÜHTER, Gerd , RUTERBORIES, Kenneth, J. , SCARBOROUGH, Robert, M. , SCHOTTEN, Theo , STENZEL, Wolfgang
IPC分类号： C07D221/20 , A61K31/435 , C07D498/10 , C07D471/10 , C07D401/06 , C07D263/52 , A61K31/42
CPC分类号： C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
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公开(公告)号：EP0963370B1
公开(公告)日：2003-03-19
申请号：EP97952325.5
申请日：1997-12-08
发明人： FISHER, Matthew, J. , FRANCISKOVICH, Jeffry, Bernard , JAKUBOWSKI, Joseph, A. , MASTERS, John, J. , SCARBOROUGH, Robert, M. , SMYTH, Mark , SU, Ting
IPC分类号： C07C311/00 , C07D211/04 , A61K31/18 , A61K31/445
CPC分类号： C07C311/06 , C07C311/19 , C07C2601/14 , C07D211/62
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公开(公告)号：EP1183234A1
公开(公告)日：2002-03-06
申请号：EP00937699.7
申请日：2000-05-24
发明人： SONG, Yonghong , CLIZBE, Lane , MARLOWE, Charles , SCARBOROUGH, Robert, M. , SU, Ting , ZHU, Bing-Yan
IPC分类号： C07C311/46 , A61K31/18 , A61P7/02
CPC分类号： C07D231/12 , C07C311/46 , C07C317/32 , C07C2601/08 , C07C2601/10 , C07D233/56 , C07D249/08 , C07D307/54 , C07D307/68 , C07D413/04
摘要： The present application relates to compounds of the general formula A-Y-D-E-G-J-K-L, wherein A, Y, D, E, G, J, K and L have the meanings given in the description, having activity against mammalian factor Xa. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP1181270A2
公开(公告)日：2002-02-27
申请号：EP00937701.1
申请日：2000-05-24
IPC分类号： C07C311/00
CPC分类号： C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP0977772A1
公开(公告)日：2000-02-09
申请号：EP98914657.6
申请日：1998-04-13
发明人： ZHU, Bing-Yan , SCARBOROUGH, Robert, M. , SU, Ting
CPC分类号： C07K5/06113 , A61K8/63 , A61K38/00 , A61Q7/00 , A61Q7/02 , C07K5/02 , C07K5/06104 , C07K5/06139
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了具有抗哺乳动物因子Xa活性的新化合物，其盐及其组合物。 这些化合物在体外或体内用于预防或治疗凝血障碍。
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公开(公告)号：EP0975625A1
公开(公告)日：2000-02-02
申请号：EP98915442.2
申请日：1998-04-13
IPC分类号： C07D401/06 , C07D241/08 , C07D295/20 , C07D417/12 , A61K31/495
CPC分类号： C07D295/205 , C07D211/26 , C07D241/08 , C07D243/08 , C07D295/15 , C07D401/06 , C07D401/12 , C07D417/12 , C07D417/14
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP0939758A1
公开(公告)日：1999-09-08
申请号：EP97911690.0
申请日：1997-10-10
CPC分类号： C07D413/14 , A61K38/00 , C07D417/12 , C07D417/14 , C07F5/025 , C07K5/06026 , C07K5/0821
摘要： Novel compound, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP0937073A2
公开(公告)日：1999-08-25
申请号：EP97912697.0
申请日：1997-10-10
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0202 , C07K5/06191
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. Their formula is (I) where the meaning of the various symbols is provided in the description.
摘要翻译： 公开了与哺乳动物因子Xa有关的新型化合物，其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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