公开(公告)号：EP2705180A4

公开(公告)日：2015-04-22

申请号：EP12782179

申请日：2012-05-03

申请人： ELWHA LLC

发明人： HYDE RODERICK A ,  KINDSVOGEL WAYNE R ,  SWEENEY ELIZABETH A ,  WOOD JR LOWELL L

IPC分类号： C40B30/04 ,  C07K16/00 ,  C40B40/10 ,  G01N33/53

CPC分类号： C07K16/00

摘要： Embodiments disclosed herein relate to methodology, and kits thereof for identifying particular disease-associated antibodies partially based on comparative binding to a mimotope array. Isolation of identified disease-associated antibodies and uses thereof are also described.

公开(公告)号：EP2794858A4

公开(公告)日：2015-05-20

申请号：EP12859056

申请日：2012-12-20

申请人： ELWHA LLC

发明人： HYDE RODERICK A ,  KINDSVOGEL WAYNE R

IPC分类号： C12N5/0781 ,  A61K35/17 ,  A61K39/00 ,  C07K16/00 ,  C07K16/10 ,  C07K16/12 ,  C07K16/30 ,  C07K16/44

CPC分类号： A61K35/17 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/6012 ,  A61K2039/6081 ,  C07K16/00 ,  C07K16/1018 ,  C07K16/109 ,  C07K16/1271 ,  C07K16/3069 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/14 ,  C07K2317/622 ,  C07K2317/76 ,  C12N5/0635 ,  C12N2510/00

摘要： Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated recombinant cell line includes an isolated B lymphocyte cell line capable of expressing at least one endogenous membrane immunoglobulin reactive to a first antigen and at least one exogenously incorporated nucleic acid encoding at least one secreted immunoglobulin reactive to a second antigen.

摘要翻译： 组合物和方法用于盘上分离的B淋巴细胞细胞系产生一个或多个免疫球蛋白游离缺失英寸 一种分离的重组细胞系包括能够表达至少一种内源免疫球蛋白膜反应性第一抗原和至少一种外源引入核酸编码至少一种免疫球蛋白分泌的反应性第二抗原的分离的B淋巴细胞细胞系。

公开(公告)号：EP3185816A4

公开(公告)日：2018-05-02

申请号：EP15835975

申请日：2015-08-25

申请人： ELWHA LLC

发明人： BANGERA MAHALAXMI GITA ,  DUNCAN WILLIAM DAVID ,  HYDE RODERICK A ,  KINDSVOGEL WAYNE R ,  SWEENEY ELIZABETH A

IPC分类号： A61F2/00 ,  A61F2/04 ,  A61K35/74 ,  A61K35/741 ,  A61K35/745 ,  A61K35/747 ,  A61L29/08

CPC分类号： A61F5/0076 ,  A61F2/04 ,  A61F2002/045 ,  A61F2210/0004 ,  A61F2210/0057 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2240/001 ,  A61K35/74 ,  A61K35/741 ,  A61K35/745 ,  A61K35/747 ,  A61K38/168 ,  A61K2035/115 ,  A61L27/54 ,  A61L29/08 ,  A61L29/148 ,  A61L29/16 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/604 ,  A61L2300/62 ,  A61L2420/02 ,  A61L2420/06

摘要： A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the inner surface and the outer surface, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.

公开(公告)号：EP2971288A4

公开(公告)日：2016-12-07

申请号：EP14773595

申请日：2014-03-11

申请人： ELWHA LLC

发明人： HYDE RODERICK A ,  KINDSVOGEL WAYNE R ,  MCKNIGHT GARY L

IPC分类号： C40B40/02 ,  C12N5/0783 ,  G06F19/00

CPC分类号： A61K39/00 ,  A61K2039/5156 ,  G06F19/18 ,  G06F19/20