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1.发明公开ADMINISTRATION OF PIRENZEPINE, METHYL SCOPOLAMINE AND OTHER MUSCARINIC RECEPTOR ANTAGONISTS FOR TREATMENT OF LIPID METABOLISM DISORDERS 失效哌仑西平，甲基东及其他毒蕈碱受体拮抗剂的脂质代谢紊乱的治疗管理
公开(公告)号：EP0764026A4
公开(公告)日：1997-12-29
申请号：EP95927259
申请日：1995-06-20
IPC分类号： A61K45/00 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/15 , A61K31/166 , A61K31/195 , A61K31/221 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/405 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/475 , A61K31/48 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K38/22 , A61K45/06 , A61P3/04 , G01N33/74 , A61K31/56 , A61K31/38 , A61K31/44 , A61K47/00
CPC分类号： A61K31/439 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/15 , A61K31/166 , A61K31/195 , A61K31/221 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/405 , A61K31/435 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/475 , A61K31/48 , A61K31/4985 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K38/2257 , A61K45/06 , G01N33/74 , Y10S514/824 , Y10S514/866 , A61K2300/00
摘要： Disclosed are methods for improving various aberrant metabolic indices in mammals including humans by administration of muscarinic (particularly M1) receptor antagonists alone or in combination with prolactin inhibiting compounds. Preferably the administration takes place at a predetermined time (or, if a combination of muscarinic receptor antagonist and prolactin inhibitor is used, at different predetermined times) during a 24-hour period when the administration is effective (or its effect more pronounced). The invention has application in the treatment of lipid and glucose metabolism disorders.
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