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1.发明公开PRIMER EXTENSION METHODS UTILIZING DONOR AND ACCEPTOR MOLECULES FOR DETECTING NUCLEIC ACIDS 审中-公开“引物延伸”的方法，使用的供体和受体分子对于核酸的检测
公开(公告)号：EP1131468A2
公开(公告)日：2001-09-12
申请号：EP99968045.7
申请日：1999-11-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6818 , C12Q1/6827 , C12Q1/6886 , C12Q2600/16 , C12Q2535/125 , C12Q2525/186 , C12Q2565/101 , C12Q2533/101
摘要： Methods are provided for selective nucleic acid sequence detection in primer extension reactions of high specificity. These methods are useful for detecting small amounts of mutant nucleic acid in a heterogeneous biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.
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2.发明授权METHODS FOR IMPROVING SENSITIVITY AND SPECIFICITY OF SCREENING ASSAYS FOR CANCER AND PRECANCER 有权方法来提高癌症和癌前体的敏感性和筛选方法的特异性
公开(公告)号：EP1185693B1
公开(公告)日：2006-08-23
申请号：EP00918364.1
申请日：2000-03-24
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Methods of the invention comprise assays for markers indicative of cancer or precancer. Assays of the invention are performed on samples obtained from a patient by non-invasive or minimally-invasive methods. The invention provides nucleic acid indicia of cancer or precancer with high sensitivities and high specificities for detection.
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3.发明授权METHODS FOR THE DETECTION OF CLONAL POPULATIONS OF TRANSFORMED CELLS IN A GENOMICALLY HETEROGENEOUS CELLULAR SAMPLE 失效过程识别转化细胞的克隆种群异质分布基因组的细胞？REN PROBE
公开(公告)号：EP0815263B1
公开(公告)日：2004-04-21
申请号：EP96944531.1
申请日：1996-12-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q2600/156 , C12Q2545/114 , C12Q2535/125 , C12Q2535/131
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公开(公告)号：EP1261739A2
公开(公告)日：2002-12-04
申请号：EP01914503.6
申请日：2001-02-27
CPC分类号： B01L3/0265 , B01L3/5025 , B01L2200/0605 , G01N2035/00247
摘要： The invention provides apparatus and methods for dividing a sample, into a plurality of subsamples without the need for pipetting or for other manual operations. Sample is placed, via inlet (2) into sample reservoir (4) in fluid communication with a main charging channel (1) which, in turn, is in fluid communication with a plurality of fractionation channels (5), with valves and vents and terminal purge channel (9). Prior to its use, the plate described above is mated with a receptacle plate, for receiving subsample via fractionation channel valves (6), and to a lid which seals the channels against leakage. The sealed device is subjected to centrifugation in order to distribute sample.
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公开(公告)号：EP1343917A2
公开(公告)日：2003-09-17
申请号：EP99962837.3
申请日：1999-11-22
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q1/6827 , C12Q2600/156 , C12Q2535/131 , C12Q2565/519 , C12Q2527/125
摘要： The present invention provides methods for the preparation of stool samples to increase the yield of relevant DNA, and further provides methods for isolating and analyzing target DNA for characteristics indicative of colorectal cancer. Methods for screening patients for the presence of cancerous or pre-cancerous colorectal lesions are also provided.
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公开(公告)号：EP1169479A2
公开(公告)日：2002-01-09
申请号：EP00921839.7
申请日：2000-04-07
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/57419 , G01N33/57473
摘要： The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer.
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公开(公告)号：EP1169479B1
公开(公告)日：2006-06-28
申请号：EP00921839.7
申请日：2000-04-07
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/57419 , G01N33/57473
摘要： The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer.
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公开(公告)号：EP0817968B1
公开(公告)日：2003-08-06
申请号：EP96946136.7
申请日：1996-12-20
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6806 , C12Q1/6858 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/57419
摘要： The present invention provides methods for screening for the presence of a subpopulation of cancerous or precancerous cells in a heterogeneous cellular sample, such as a stool sample. The methods take advantage of the recognition that cellular debris from cancerous and precancerous cells is deposited onto only a longitudinal stripe of stool as the stool is forming in the colon. Accordingly, methods of the invention comprise obtaining a representative sample, such as a cross-sectional sample of stool in order to ensure that any cellular debris that is shed by colonic cells is obtained in the sample.
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9.发明公开
公开(公告)号：EP1185693A2
公开(公告)日：2002-03-13
申请号：EP00918364.1
申请日：2000-03-24
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Methods of the invention comprise assays for markers indicative of cancer or precancer. Assays of the invention are performed on samples obtained from a patient by non-invasive or minimally-invasive methods. The invention provides nucleic acid indicia of cancer or precancer with high sensitivities and high specificities for detection.
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