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公开(公告)号：EP1238103B1
公开(公告)日：2009-01-07
申请号：EP00960085.9
申请日：2000-09-08
发明人： SHUBER, Anthony, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
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公开(公告)号：EP1238103A2
公开(公告)日：2002-09-11
申请号：EP00960085.9
申请日：2000-09-08
发明人： SHUBER, Anthony, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
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3.发明公开PRIMER EXTENSION METHODS UTILIZING DONOR AND ACCEPTOR MOLECULES FOR DETECTING NUCLEIC ACIDS 审中-公开“引物延伸”的方法，使用的供体和受体分子对于核酸的检测
公开(公告)号：EP1131468A2
公开(公告)日：2001-09-12
申请号：EP99968045.7
申请日：1999-11-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6818 , C12Q1/6827 , C12Q1/6886 , C12Q2600/16 , C12Q2535/125 , C12Q2525/186 , C12Q2565/101 , C12Q2533/101
摘要： Methods are provided for selective nucleic acid sequence detection in primer extension reactions of high specificity. These methods are useful for detecting small amounts of mutant nucleic acid in a heterogeneous biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.
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4.发明授权METHODS FOR IMPROVING SENSITIVITY AND SPECIFICITY OF SCREENING ASSAYS FOR CANCER AND PRECANCER 有权方法来提高癌症和癌前体的敏感性和筛选方法的特异性
公开(公告)号：EP1185693B1
公开(公告)日：2006-08-23
申请号：EP00918364.1
申请日：2000-03-24
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Methods of the invention comprise assays for markers indicative of cancer or precancer. Assays of the invention are performed on samples obtained from a patient by non-invasive or minimally-invasive methods. The invention provides nucleic acid indicia of cancer or precancer with high sensitivities and high specificities for detection.
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5.发明授权METHODS FOR THE DETECTION OF CLONAL POPULATIONS OF TRANSFORMED CELLS IN A GENOMICALLY HETEROGENEOUS CELLULAR SAMPLE 失效过程识别转化细胞的克隆种群异质分布基因组的细胞？REN PROBE
公开(公告)号：EP0815263B1
公开(公告)日：2004-04-21
申请号：EP96944531.1
申请日：1996-12-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q2600/156 , C12Q2545/114 , C12Q2535/125 , C12Q2535/131
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公开(公告)号：EP1644529A2
公开(公告)日：2006-04-12
申请号：EP04776825.4
申请日：2004-06-21
发明人： SHUBER, Anthony, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Methods of the invention generally include measuring a quantitative amount of nucleic acid in a patient sample, and optionally, performing additional disease testing on the patient. Methods of the invention are useful in screening disease in a patient, such as cancer.
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公开(公告)号：EP1343917A2
公开(公告)日：2003-09-17
申请号：EP99962837.3
申请日：1999-11-22
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q1/6827 , C12Q2600/156 , C12Q2535/131 , C12Q2565/519 , C12Q2527/125
摘要： The present invention provides methods for the preparation of stool samples to increase the yield of relevant DNA, and further provides methods for isolating and analyzing target DNA for characteristics indicative of colorectal cancer. Methods for screening patients for the presence of cancerous or pre-cancerous colorectal lesions are also provided.
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公开(公告)号：EP1203100A2
公开(公告)日：2002-05-08
申请号：EP00953902.4
申请日：2000-08-09
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2533/101 , C12Q2535/101
摘要： Methods for detecting nucleotide deletions in biological samples are described. Methods of the invention are particularly useful for detecting deletions in regions of polynucleotide repeats. In particular, methods of the invention are useful to detect deletions at the BAT26 locus.
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公开(公告)号：EP1169479A2
公开(公告)日：2002-01-09
申请号：EP00921839.7
申请日：2000-04-07
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/57419 , G01N33/57473
摘要： The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer.
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公开(公告)号：EP1155147A1
公开(公告)日：2001-11-21
申请号：EP00904537.8
申请日：2000-01-24
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/1003 , C12Q2527/125
摘要： Methods for extracting DNA from a biological sample that result in a higher yield of target DNA than conventional methods. More particularly, methods for extracting DNA include exposing the biological sample to inhibitors of DNA degradation.
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