公开(公告)号：EP1539962A1

公开(公告)日：2005-06-15

申请号：EP04761767.5

申请日：2004-09-10

申请人： Ecopia Biosciences Inc.

发明人： MCALPINE, James, B. ,  FARNET, Chris, M. ,  ZAZOPOULOS, Emmanuel ,  SORENSEN, Dan

IPC分类号： C12N15/52 ,  C12N15/63 ,  C12P17/06 ,  C12P17/16 ,  C07D309/10 ,  C07D493/04 ,  C12P1/04 ,  C12N1/20 ,  A61P31/04 ,  A61K31/35 ,  C12P21/02 ,  C12N15/31 ,  C12N9/00 ,  C07K14/195

CPC分类号： C07C279/14 ,  C07C2601/10 ,  C07D309/10 ,  C07H5/04 ,  C07H5/06 ,  C12N15/52 ,  C12P7/42 ,  C12P13/001 ,  C12P13/02 ,  C12P17/06 ,  C12P17/16 ,  C12P19/44 ,  C12R1/01 ,  Y10S435/821

摘要： Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. Formula (I) One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC™ 43491 or a mutant or variant such as the strain IDAC-220604-1. Another method for obtaining the compounds is post-biosynthesis chemical modification of the compounds obtained by cultivation. Novel polynucleotide sequences and encoded proteins for the biosynthesis of the polyene polyketides are also presented.

摘要翻译： 已经发现新型多烯聚酮化合物，其药学上可接受的盐，前药和衍生物具有抗生素活性。 获得化合物的一种方法是通过种植侧寄生菌ATCC 43491或突变体或变体例如菌株IDAC-220604-1。 获得化合物的另一种方法是通过培养获得的化合物的后生物合成化学修饰。 还提出了用于多烯聚酮化合物的生物合成的新型多核苷酸序列和编码的蛋白质。