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公开(公告)号：EP1983047A1
公开(公告)日：2008-10-22
申请号：EP07708219.6
申请日：2007-02-08
发明人： YOSHIDA, Shigeto , OHBA, Yoshio , HARIGUCHI, Norimitsu , MIZUKOSHI, Masami , KAWASAKI, Masanori , MATSUMOTO, Makoto , GOTO, Yoshihiro
CPC分类号： C12N15/86 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , C07K14/005 , C07K2319/02 , C07K2319/43 , C12N2710/14143 , C12N2760/16134 , C12N2830/205 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： A recombinant transfer vector capable of expressing a foreign gene fused to a viral gene under the control of dual promoters and a recombinant baculovirus, and methods for production thereof, as well as pharmaceuticals comprising the recombinant baculovirus as an active ingredient.
摘要翻译： 能够在双重启动子和重组杆状病毒的控制下表达与病毒基因融合的外源基因的重组转移载体及其制备方法，以及包含重组杆状病毒作为活性成分的药物。
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2.发明公开BACULOVIRAL VECTORS WITH A DUAL VERTEBRATE AND BACULOVIRUS PROMOTER CONTROLLING AN IMMUNOGENIC FUSION GENE. 有权WITH A杆状病毒载体监测的免疫原性融合脊椎动物和杆状病毒双启动子
公开(公告)号：EP2191002A2
公开(公告)日：2010-06-02
申请号：EP08792433.8
申请日：2008-08-06
发明人： YOSHIDA, Shigeto , KAWASAKI, Masanori , MATSUMOTO, Makoto , OHBA, Yoshio , SAITO, Masahiro , GOTO, Yoshihiro , INAGAKI, Katsuya , MIZUKOSHI, Masami , HARIGUCHI, Norimitsu , HIROTA, Kuniko
IPC分类号： C12N15/866 , A61K39/145 , A61K39/015
CPC分类号： C07K16/1018 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K14/445 , C07K16/205 , C07K2319/735 , C12N7/00 , C12N15/86 , C12N2710/14122 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , C12N2830/15 , C12N2830/60 , C12N2830/85 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient.
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3.发明授权BACULOVIRAL VECTORS WITH A DUAL VERTEBRATE AND BACULOVIRUS PROMOTER CONTROLLING AN IMMUNOGENIC FUSION GENE. 有权WITH A杆状病毒载体监测的免疫原性融合脊椎动物和杆状病毒双启动子
公开(公告)号：EP2191002B1
公开(公告)日：2016-04-13
申请号：EP08792433.8
申请日：2008-08-06
发明人： YOSHIDA, Shigeto , KAWASAKI, Masanori , MATSUMOTO, Makoto , OHBA, Yoshio , SAITO, Masahiro , GOTO, Yoshihiro , INAGAKI, Katsuya , MIZUKOSHI, Masami , HARIGUCHI, Norimitsu , HIROTA, Kuniko
IPC分类号： C12N15/866 , A61K39/145 , A61K39/015
CPC分类号： C07K16/1018 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K14/445 , C07K16/205 , C07K2319/735 , C12N7/00 , C12N15/86 , C12N2710/14122 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , C12N2830/15 , C12N2830/60 , C12N2830/85 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient.
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公开(公告)号：EP2626418B1
公开(公告)日：2020-12-09
申请号：EP11830662.0
申请日：2011-10-04
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公开(公告)号：EP2757373A1
公开(公告)日：2014-07-23
申请号：EP12832236.9
申请日：2012-09-13
发明人： SUGIYAMA, Haruo , OJI, Yusuke , KATSURAGI, Kiyonori , TANAKA, Hideaki , SOGO, Shinji , GOTO, Yoshihiro , OHMOTO, Yasukazu , IWATA, Husako
IPC分类号： G01N33/53 , C07K14/82 , C12N15/09 , A61K39/00 , G01N33/574
CPC分类号： G01N33/574 , A61K39/0011 , C07K14/82 , G01N33/57407 , G01N33/57419 , G01N33/57426 , G01N33/57488 , G01N33/6854
摘要： Provided is an invention relating to a method for measuring an anti-WT1 antibody in a sample allowing measurement and evaluation of the anti-WT1 antibody with higher accuracy and to use of the method. The method for measuring an anti-WT1 antibody in a sample includes using a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 294-449 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides and/or a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 181-324 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides.
摘要翻译： 本发明涉及一种测定样品中的抗WT1抗体的方法的发明，其能够更准确地测定和评价抗WT1抗体并使用该方法。 用于测量样品中抗WT1抗体的方法包括使用对抗WT1抗体具有抗原性的多肽，所述抗WT1抗体选自包含SEQ ID NO：1中294-449位氨基酸序列的多肽， 多肽和包含在构成每个这些多肽的氨基酸序列中具有1至数个氨基酸的缺失，取代或添加的氨基酸序列的多肽和/或对抗WT1抗体具有抗原性的多肽，所述抗WT1抗体选自多肽 其包含SEQ ID NO：1中的位置181-324的氨基酸序列，多肽的部分多肽，以及包含在氨基酸序列中具有一至几个氨基酸的缺失，取代或添加的氨基酸序列的多肽 构成这些多肽中的每一种。
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公开(公告)号：EP2626418A1
公开(公告)日：2013-08-14
申请号：EP11830662.0
申请日：2011-10-04
IPC分类号： C12N5/0783 , A61K31/711 , A61K35/12 , A61K35/76 , A61K38/00 , A61K48/00 , A61P35/00 , C07K16/32 , C12N5/0784 , C12N5/0786 , C12Q1/02 , C07K14/82
CPC分类号： C07K7/08 , A61K35/17 , A61K39/0011 , A61K2039/5158 , A61K2039/57 , C07K14/82 , C12N5/0636 , C12N5/0638 , C12N2501/2302 , C12N2501/2307
摘要： The present invention relates to a method for activating helper T cells, which includes the step of activating helper T cells by adding a WT1 peptide to antigen presenting cells, wherein the WT1 peptide has the ability to bind to any MHC class II molecule of an HLA-DRB1*0101 molecule, an HLA-DRB1*0401 molecule, an HLA-DRB1*0403 molecule, an HLA-DRB1*0406 molecule, an HLA-DRB1*0803 molecule, an HLA-DRB1*0901 molecule, an HLA-DRB1*1101 molecule, an HLA-DRB3*0202 molecule, an HLA-DRB4*0101 molecule, an HLA-DPB1*0201 molecule or an HLA-DPB1*0301 molecule, and the like.
摘要翻译： 本发明涉及一种激活辅助性T细胞的方法，其包括通过向抗原呈递细胞添加WT1肽来激活辅助性T细胞的步骤，其中WT1肽具有结合HLA的任何MHC II类分子的能力 -DRB1 * 0101分子，HLA-DRB1 * 0401分子，HLA-DRB1 * 0403分子，HLA-DRB1 * 0406分子，HLA-DRB1 * 0803分子，HLA-DRB1 * 0901分子，HLA-DRB1 HLA-DRB3 * 0202分子，HLA-DRB4 * 0101分子，HLA-DPB1 * 0201分子或HLA-DPB1 * 0301分子等。
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