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公开(公告)号：EP0973725B1
公开(公告)日：2002-06-19
申请号：EP97911385.9
申请日：1997-10-16
发明人： GACSALYI, István , KLEBOVICH, Imre , BUDAI, Zoltán , LUKACS, Gyula , KAUFMANNE BOJTI, Erzsébet , SCHMIDT, Eva , GYERTYAN, István , BILKEI GORZO, András , BLASKO, Gábor , ABERMANN, Miklos , BALOGHNE NEMES, Katalin , GREZAL, Gyula , EGYED, András
IPC分类号： C07C217/00
CPC分类号： C07C217/12 , C07C2602/42 , Y02P20/55
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2.发明公开SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权取代的烷基氨基哒嗪酮衍生物，其制备方法和含有该化合物的药物组合物
公开(公告)号：EP1430034A1
公开(公告)日：2004-06-23
申请号：EP02767729.3
申请日：2002-09-26
发明人： BARK CZY, József , SIMIG, Gyula , KOTAY NAGY, Péter; , LEVAY, György , GACSALYI, István , MARTONNE MARKO, Bernadett , SCHMIDT, Eva , EGYED, András , KOMPAGNE, Hajnalka; , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikú , SZENASI, Gábor , WELLMANN, János , HARSING, Lászlú Gábor
IPC分类号： C07D237/22 , C07D401/12 , C07D403/12 , A61K31/50 , A61P25/22 , A61P25/28
CPC分类号： C07D401/12 , C07D237/22 , C07D403/12 , C07D405/12
摘要： New substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; X is hydrogen or halogen; R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Q and W independently from each other stand for -N= or -CH=; and R4 and R5 independently from each other represent hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof possess useful anxiolytic and cognition enhancing properties.
摘要翻译： 通式（I）的新取代的烷基氨基哒嗪酮衍生物，其中R1是氢或具有1-4个碳原子的烷基; X是氢或卤素; R2是氢或具有1-4个碳原子的烷基; n是1,2或3。 3; Q和W彼此独立地代表-N =或-CH =;且R 4和R 5彼此独立地表示氢，卤素，三氟甲基或具有1-4个碳原子的烷氧基）及其药学上可接受的酸加成盐具有 有用的抗焦虑和认知增强特性。
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3.发明公开SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS 审中-公开取代的烷基哒嗪酮对记忆和学习的薄弱环节处理
公开(公告)号：EP1567159A1
公开(公告)日：2005-08-31
申请号：EP03777020.3
申请日：2003-11-13
发明人： LEVAY, György , GACSALYI, István , MARKO, Bernadett , SCHMIDT,Eva , EGYED, András , KOMPAGNE, Hajnalka , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikó , SZENASI, Gábor , WELLMANN, János , HARSING, László Gábor , BARKOCZY, József , SIMIG, Gyula , KOTAY NAGY, Péter
IPC分类号： A61K31/501 , A61P25/28
CPC分类号： A61K31/501
摘要： The compounds of the general Formula I, wherein R1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R2 is hydrogen or lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R3 and Z together with the intermediate atoms form a piperazino ring; Q and W independently from each other stands for -CH= or -N=; and R4, R5 and R6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R4 and R5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.
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4.发明授权SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权取代的烷基氨基哒嗪酮衍生物，其制备方法和含有该化合物的药物组合物
公开(公告)号：EP1430047B1
公开(公告)日：2005-02-09
申请号：EP02762620.9
申请日：2002-09-26
发明人： BARKOCZY, Júzsef , SIMIG, Gyula , KOTAY NAGY, Péter , LEVAY, György , GACSALYI, István , MARTONNE MARKO, Bernadett , SCHMIDT, Eva , EGYED, András , KOMPAGNE, Hajnalka , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikú , SZENASI, Gábor , WELLMANN, János , HARSING, Lászlú, Gábor
IPC分类号： C07D401/12 , A61K31/50 , A61P25/22 , A61P25/28
CPC分类号： C07D401/12 , C07D237/22 , C07D403/12 , C07D405/12
摘要： The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.
摘要翻译： 本发明涉及通式（I）的新的取代的烷基氨基哒嗪酮衍生物，其中R 1是氢或具有1-4个碳原子的烷基; X和Y中的一个代表氢或卤素，另一个代表通式 （II）中，R2是氢或具有1-4个碳原子的烷基; n是1,2或3; R3代表氢，具有1-4个碳原子的烷基或芳基 - （C1-4烷基）; Z代表氧 ;或者R3和Z与它们之间的基团一起形成哌嗪环; R4代表氢，卤素，三氟甲基或具有1-4个碳原子的烷氧基）及其药学上可接受的酸加成盐。 本发明化合物可用于治疗抗焦虑症和认知障碍。
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公开(公告)号：EP1200442B8
公开(公告)日：2003-08-20
申请号：EP00944129.6
申请日：2000-07-04
发明人： GREFF, Zoltán , SZAB , Géza , BARK CZY, József , R TKAI, Zoltán , BLASK , Gábor , SIMIG, Gyula , GIGLER, Gábor , MARTONN MARK , Bernadett , L VAY, György , TIHANYI, Károly , EGYED, András , SIM , Annamária
IPC分类号： C07D491/04 , A61K31/551 , A61P25/00
CPC分类号： C07D491/04
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6.发明公开SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权取代ALKYLAMINOPYRIDAZINONDERIVATE，其制造方法SAME和药物制剂
公开(公告)号：EP1430047A1
公开(公告)日：2004-06-23
申请号：EP02762620.9
申请日：2002-09-26
发明人： BARKOCZY, Júzsef , SIMIG, Gyula , KOTAY NAGY, Péter , LEVAY, György , GACSALYI, István , MARTONNE MARKO, Bernadett , SCHMIDT, Eva , EGYED, András , KOMPAGNE, Hajnalka , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikú , SZENASI, Gábor , WELLMANN, János , HARSING, Lászlú, Gábor
IPC分类号： C07D401/12 , A61K31/50 , A61P25/22 , A61P25/28
CPC分类号： C07D401/12 , C07D237/22 , C07D403/12 , C07D405/12
摘要： The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.
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7.发明公开
公开(公告)号：EP1417206A1
公开(公告)日：2004-05-12
申请号：EP02755381.7
申请日：2002-07-24
发明人： BARKOCZY, Jozsef , KOTAY NAGY, Péter , SIMIG, Gyula , LEVAY, György , GACSALYI, István , EGYED, András , RACZNE BAJNOGEL, Judit , PALLAGI, Katalin , SCHMIDT, Eva , SZENASI, Gábor , MIKLOSNE KOVACS, Aniko , WELLMANN, János
IPC分类号： C07D413/14 , A61K31/50
CPC分类号： C07D413/14
摘要： The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. In formula I, R stands for a hydrogen atom or a C1-4 alkyl group, X and Y represent, independently, a hydrogen atom, a halogen atom or a group of the formula II, with the proviso that one of X and Y means always a group of the formula II, and then the other one stands for a hydrogen atom or a halogen atom, wherein in formula II n has a value of 1 or 2.
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8.发明授权PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS 失效Piperazinylalkylthiopyrimidine衍生物含有药物组合物及其方法
公开(公告)号：EP0901473B1
公开(公告)日：2002-03-13
申请号：EP96935194.9
申请日：1996-10-25
发明人： JAKOCZI, Iván , BOZSING, Dániel , RATZNE SIMONEK, Ildiko , GACSALYI, István , SZENASI, Gábor , SCHMIDT, Eva , MIKLESNE KOVACS, Aniko , BILKEI GORZO, András , BLASKO, Gábor , GYERTYAN, István , NEMETH, Gábor , SIMIG, Gyula , TIHANYI, Károly , EGYED, András
IPC分类号： C07D239/38 , C07D239/22 , C07D239/48 , C07D239/46 , A61K31/505
CPC分类号： C07D239/22 , C07D239/38 , C07D239/47 , C07D239/48
摘要： The invention refers to novel piperazinylalkylthiopyrimidine derivatives of formula (I) being suitable for the treatment of diseases due to pathological alterations of the central nervous system, pharmaceutical compositions containing the above derivatives, and a process for the preparation of the novel compounds.
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9.发明公开1,3-DIOXOLO/4,5-H//2,3/BENZODIAZEPINE DERIVATIVES AS AMPA/KAINATE RECEPTOR INHIBITORS 有权1-3二氧杂环戊烯/ 4.5-H // 2,3-苯并二氮杂衍生物作为AMPA /红藻氨酸受体抑制剂
公开(公告)号：EP1015457A1
公开(公告)日：2000-07-05
申请号：EP98939782.3
申请日：1998-08-07
发明人： BARKOCZY, Júzsef , CSELENYAK, Judit , RATKAI, Zoltán , SIMIG, Gyula , BALAZS, Lászlo , DOMAN, Imre , KOTAY NAGY, Péter , GREFF, Zoltán , SERES, Péter , SZABO, Géza , GACSALYI, István , GIGLER, Gábor , GYERTYAN, István , LEVAY, György , KOVACS, Attila , SIMO, Annamária , SZABADOS, Tamás , EGYED, András , VEGH, Miklos , TIHANYI, Károly
IPC分类号： C07D491/04 , A61K31/55
CPC分类号： C07D491/04
摘要： The invention refers to 1,3-dioxolo-/4,5-h//2,3/benzodiazepine derivatives of formula (I), a process for preparing these compounds and to pharmaceutical compositions containing these active substances, which are used to selectively inhibit Ampa/Kainate receptors.
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公开(公告)号：EP0973725A2
公开(公告)日：2000-01-26
申请号：EP97911385.9
申请日：1997-10-16
发明人： GACSALYI, István , KLEBOVICH, Imre , BUDAI, Zoltán , LUKACS, Gyula , KAUFMANNE BOJTI, Erzsébet , SCHMIDT, Eva , GYERTYAN, István , BILKEI GORZO, András , BLASKO, Gábor , ABERMANN, Miklos , BALOGHNE NEMES, Katalin , GREZAL, Gyula , EGYED, András
IPC分类号： C07C217/00
CPC分类号： C07C217/12 , C07C2602/42 , Y02P20/55
摘要： The new compound of Formula (I) and salts thereof possess valuable anxiolytic properties.
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