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    METHOD FOR MEASUREMENT OF EQUOL IN BIOLOGICAL SAMPLE BY IMMUNOASSAY, KIT FOR THE MEASUREMENT, AND METHOD FOR DETERMINATION OF EQUOL PRODUCTION ABILITY OF SUBJECT
    2.
    发明公开
    METHOD FOR MEASUREMENT OF EQUOL IN BIOLOGICAL SAMPLE BY IMMUNOASSAY, KIT FOR THE MEASUREMENT, AND METHOD FOR DETERMINATION OF EQUOL PRODUCTION ABILITY OF SUBJECT 有权
    方法在生物样品利用一个免疫检测，KIT为确定EQUOLHERSTELLUNGSKAPAZITÄT一个人测量和测量方法测EQUOLGEHALTS的

    公开(公告)号：EP2431740A1

    公开(公告)日：2012-03-21

    申请号：EP10774917.8

    申请日：2010-05-11

    申请人： Eiken Kagaku Kabushiki Kaisha ,  Otsuka Pharmaceutical Co., Ltd.

    发明人： MINEKAWA,Takayuki ,  SHINDOME, Kumiko ,  ABE, Katsushi ,  OKUMA, Hiroshi ,  ANDO, Chieko ,  ABIRU, Yasuhiro

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5308 ,  C07K16/44

    摘要： An object of the present invention is to provide a method for measuring equal in a biological sample by an immunological method, a kit for the measurement, and a method for determining equol-producing ability of a subject.
    The measurement method of the present invention is characterized in that S-equol is used as at least one antigen selected from the group consisting of a standard antigen used for the preparation of a standard curve and a labeled antigen that competes with equol in a biological sample. The kit of the present invention is characterized in including S-equol as at least one antigen selected from the group consisting of the standard antigen and the labeled antigen. The determination method of the present invention includes steps of measuring equal in a biological sample derived from a subject who has ingested soybean isoflavane by an immunological method using S-equol as at least one antigen selected from the group consisting of the standard antigen and the labeled antigen, and determining an equol-producing ability of the subject based on the measured value of equol obtained in the above step.

    摘要翻译： 本发明的一个目的是提供一种用于在免疫学方法测量相等的生物样品中通过提供一种方法，用于测量的试剂盒，以及用于受试者的确定性采矿雌马酚产生能力的方法。 本发明的测定方法中也S-雌马酚被用作选自用于标准曲线的制备和标记抗原的标准抗原中的至少一种抗原与雌马酚做竞争的生物样品中的特征 ， 本发明的试剂盒中，包括S-牛尿酚的特征为选自以下的标准抗原和标记的抗原中的至少一种抗原。 本发明的测定方法包括使用S-牛尿酚测量从谁已经通过免疫学方法摄取大豆isoflavanes的受试者的生物样品中的相等的步骤选自下组的标准抗原和标记的选择的至少一种抗原 抗原，以及基于在上述工序中得到的雌马酚的测量值的受试者的雌马酚产生能力的确定性挖掘。

    FERMENTATION PRODUCT CONTAINING EQUOL-PRODUCING MICROORGANISM HAVING MAINTAINED EQUOL-PRODUCING ABILITY, AND METHOD FOR PRODUCING SAME
    5.
    发明公开
    FERMENTATION PRODUCT CONTAINING EQUOL-PRODUCING MICROORGANISM HAVING MAINTAINED EQUOL-PRODUCING ABILITY, AND METHOD FOR PRODUCING SAME 有权
    含有产生维持平衡能力的平衡产生微生物的发酵产物及其制备方法

    公开(公告)号：EP2335500A1

    公开(公告)日：2011-06-22

    申请号：EP09814682.2

    申请日：2009-09-18

    申请人： Otsuka Pharmaceutical Co., Ltd. ,  Otsuka Foods Co., Ltd.

    发明人： ISONO, Yoshikazu ,  MORI, Hisako ,  UENO, Tomomi ,  ENDO, Rieko ,  KUMEMURA, Megumi ,  ABIRU, Yasuhiro ,  UCHIYAMA, Shigeto

    IPC分类号： A23L1/20 ,  A23C9/123 ,  A23C9/13

    CPC分类号： C12P17/06 ,  A23C9/1236 ,  A23C9/1315 ,  A23C11/106 ,  A23L11/09 ,  A23L29/065 ,  A23L33/135 ,  A23Y2240/00 ,  C07D311/60

    摘要： An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained.
    When producing a fermented material by using an (equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pit 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.

    摘要翻译： 本发明的目的在于提供一种含有雌马酚产生微生物的发酵产物，该微生物处于维持雌马酚产生能力的活细胞状态。 在以（牛尿酚产生微生物，大豆粉或豆浆为原料）制造发酵物的情况下，（1）在大豆黄素类物质的存在下，使用产生牛尿酚的微生物，在厌氧条件下进行发酵而制备母发酵剂 （2）在大肠杆菌5.0或更高的大豆黄素种类的存在下，通过使用所述母发酵剂，在厌氧条件下通过发酵制备发酵起始剂，以及（3）通过使用所述大块发酵制备发酵材料 在含有大豆粉或豆浆的培养基中进行发酵，能够制造含有维持雌马酚的生产能力的活细胞状态的微生物的发酵物。

    ENZYME INVOLVED IN SYNTHESIS OF EQUOL
    8.
    发明公开
    ENZYME INVOLVED IN SYNTHESIS OF EQUOL 有权
    AN DER合成VON EQUOL BETEILIGTES ENZYM

    公开(公告)号：EP2228441A1

    公开(公告)日：2010-09-15

    申请号：EP08867315.7

    申请日：2008-12-25

    申请人： Otsuka Pharmaceutical Co., Ltd.

    发明人： SHIMADA, Yoshikazu ,  YASUDA, Setsuko ,  TAKAHASHI, Masayuki ,  HAYASHI, Takashi ,  MIYAZAWA, Norihiro ,  ABIRU, Yasuhiro ,  OHTANI, Tadaaki ,  SATO, Ikutaro

    IPC分类号： C12N9/02 ,  C12N15/09 ,  C12P17/18

    CPC分类号： C12P17/06 ,  C12N9/00 ,  C12N9/0073 ,  C12N9/93

    摘要： An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes.
    The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.

    摘要翻译： 本发明的目的是提供与雌马酚合成相关的酶，编码这些酶的基因，以及使用酶和基因产生雌马酚及其中间体的方法。 本发明提供二氢黄豆苷元合成酶，四氢黄豆苷元合成酶，雌马酚合成酶，以及编码这些酶的基因。 本发明还提供了使用这些酶合成二氢黄豆苷元，四氢黄豆苷元和/或雌马酚的方法。