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    Naphthalene derivative
    7.
    发明公开
    Naphthalene derivative 失效
    Naphthalinderivate。

    公开(公告)号：EP0376288A1

    公开(公告)日：1990-07-04

    申请号：EP89124034.3

    申请日：1989-12-28

    申请人： Eisai Co., Ltd.

    发明人： Okita, Makoto ,  Shirota, Hiroshi ,  Tanaka, Masayuki ,  Kaneko, Toshihiko ,  Tagami, Katsuya ,  Hibi, Shigeki ,  Okamoto, Yasushi ,  Nomoto, Seiichiro ,  Suzuki, Takeshi ,  Chiba, Kenichi ,  Goto, Masaki ,  Hashida, Ryoichi ,  Ono, Hideki ,  Ohhara, Hideto ,  Sakurai, Hideki ,  Souda, Shigeru ,  Machida, Yoshimasa ,  Katayama, Kouichi ,  Yamatsu, Isao

    IPC分类号： C07C59/52 ,  C07C59/64 ,  C07C69/157 ,  C07C69/732 ,  C07C69/734 ,  C07D295/182 ,  C07C49/83 ,  C07C49/84 ,  C07C47/565 ,  C07C47/575 ,  A61K31/19

    CPC分类号： C07F7/1852 ,  C07C39/225 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/313 ,  C07C43/315 ,  C07C45/00 ,  C07C45/298 ,  C07C45/30 ,  C07C45/305 ,  C07C45/513 ,  C07C45/54 ,  C07C45/59 ,  C07C45/63 ,  C07C45/71 ,  C07C47/57 ,  C07C47/575 ,  C07C49/83 ,  C07C49/84 ,  C07C59/68

    摘要： A naphthalene derivative having the formula is new and useful for medicine.
    [wherein R 1 represents a hydrogen atom, a lower alkyl group or an acyl group;

    R 2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;
    R 3 and R 4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may be substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;
    R 5 represents a group of the formula, -OR?, (wherein R represents a hydrogen atom or a lower alkyl group), or a group of the formula,
    (wherein R 8 and R 9 are the same or different and represent a hydrogen atom or alower alkyl group or R 8 and R 9 can form, along with the nitrogen atom bonded with R 8 and R 9 , a ring which may contain an oxygen atom);
    R 6 independently represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, an amino group, an arylalkyl group, or an aryl group; and
    m is 0 or an integer of from 1 to 2, and n is 0 or an integer of from 1 to 4.]

    摘要翻译： 具有该式的萘衍生物是新的并且可用于药物。 [其中R 1表示氢原子，低级烷基或酰基; R 2独立地表示氢原子，低级烷基，低级烷氧基，卤素原子，环烷基，环烷基烷基，羟基，可被取代的芳基，芳基 可以被取代，杂芳基或杂芳基烷基; R 3和R 4相同或不同，表示氢原子，低级烷基，低级烯基，可以被取代的芳基，芳基可以被取代的芳基烷基，芳基烯基 芳基可以被取代的基团，环烷基，烷氧基烷基，杂芳基，杂芳基烷基，羧基，羧基烷基，氨基烷基或氰基; R 5表示下式基团-OR 7（其中R 7表示氢原子或低级烷基）或下式基团（其中R 8为 和R 9相同或不同，表示氢原子或低级烷基，或者R 8和R 9可以与与R 8和R 9键合的氮原子一起形成， 可能含有氧原子的环）; R 6独立地表示氢原子，卤素原子，低级烷基，低级烷氧基，羟基，氨基，芳基烷基或芳基。 m为0或1〜2的整数，n为0或1〜4的整数。]