公开(公告)号：EP2791097A1

公开(公告)日：2014-10-22

申请号：EP12816705.3

申请日：2012-12-11

Applicant: Université Paris-Sud XI

Inventor： HUC, Vincent, Germain ,  MARTINI, Cyril

IPC: C07C41/30 ,  C07C43/253

CPC classification number: C07C41/30 ,  C07C43/23 ,  C07C2603/90 ,  C07C43/253

Abstract: The present invention relates to the high‑yield synthesis of p- (benzyloxy)calix[6, 7, 8]arenes. (no drawings)

Abstract translation: 通过使氢氧化铯与对 - （苄氧基）苯酚和多聚甲醛接触，以及包括这些对 - （苄氧基）杯[6， 7,8]芳烃。

公开(公告)号：EP2345629A4

公开(公告)日：2012-06-13

申请号：EP09819281

申请日：2009-10-09

Applicant: JAPAN TOBACCO INC

Inventor： MOTOMURA TAKAHISA ,  NAGAMORI HIRONOBU ,  SUZAWA KOICHI ,  ITO HIROTSUGU ,  MORITA TORU ,  KOBAYASHI SATORU ,  SHINKAI HISASHI

IPC: C07C35/52 ,  A61K31/045 ,  A61K31/05 ,  A61K31/085 ,  A61K31/10 ,  A61K31/121 ,  A61K31/136 ,  A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/235 ,  A61K31/277 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4196

CPC classification number: C07D205/04 ,  A61K31/045 ,  A61K31/05 ,  A61K31/085 ,  A61K31/10 ,  A61K31/121 ,  A61K31/136 ,  A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/235 ,  A61K31/277 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4523 ,  A61K31/5375 ,  C07C35/52 ,  C07C39/42 ,  C07C43/23 ,  C07C43/253 ,  C07C49/83 ,  C07C59/56 ,  C07C59/72 ,  C07C65/17 ,  C07C69/712 ,  C07C69/732 ,  C07C69/76 ,  C07C215/44 ,  C07C215/70 ,  C07C217/20 ,  C07C233/18 ,  C07C233/25 ,  C07C235/42 ,  C07C235/66 ,  C07C255/12 ,  C07C255/53 ,  C07C259/10 ,  C07C271/16 ,  C07C271/30 ,  C07C311/04 ,  C07C317/22 ,  C07C2603/18 ,  C07D207/04 ,  C07D211/06 ,  C07D213/30 ,  C07D213/56 ,  C07D231/12 ,  C07D239/26 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D295/08 ,  C07D295/18 ,  C07D295/192 ,  C07D333/22 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07F7/0818

公开(公告)号：EP1498406A1

公开(公告)日：2005-01-19

申请号：EP04015462.7

申请日：2000-10-26

Applicant: AstraZeneca AB

Inventor： Fagnou, Keith ,  Lautens, Mark, Prof. Dep. of Chemistry

IPC: C07C43/18 ,  C07C69/013

CPC classification number: C07D295/096 ,  C07B2200/07 ,  C07C41/01 ,  C07C43/196 ,  C07C43/23 ,  C07C43/253 ,  C07C45/71 ,  C07C49/84 ,  C07C67/24 ,  C07C69/013 ,  C07C69/732 ,  C07C205/38 ,  C07C215/44 ,  C07C217/52 ,  C07C255/54 ,  C07C271/24 ,  C07C311/20 ,  C07C2602/10 ,  C07D209/08 ,  C07D215/06 ,  C07D217/04 ,  C07D295/135 ,  C07F7/0818 ,  C07F7/1856 ,  C07C69/16 ,  C07C69/78 ,  C07C69/08 ,  C07C69/54 ,  C07C69/38

Abstract: The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.

Abstract translation: 本发明涉及制备含有水合萘环结构的对映体富集化合物的方法。 该方法包括使用铑作为催化剂和在膦配体的存在下，使异丁苯并苯并异戊二烯与亲核试剂反应。 合成的化合物可用于治疗各种疾病和病症的药物制剂中。

公开(公告)号：EP0626957B1

公开(公告)日：1999-03-03

申请号：EP94902933.4

申请日：1993-12-22

Applicant: CELLTECH THERAPEUTICS LIMITED

Inventor： WARRELLOW, Graham John ,  BOYD, Ewan Campbell ,  ALEXANDER, Rikki Peter

IPC: C07D405/06 ,  C07D409/06 ,  C07D233/64 ,  C07D213/30 ,  C07D213/38 ,  C07D213/55 ,  C07D213/36 ,  C07D213/40

CPC classification number: C07D213/30 ,  C07C43/243 ,  C07C43/247 ,  C07C43/253 ,  C07C65/26 ,  C07C69/94 ,  C07D213/36 ,  C07D213/38 ,  C07D213/40 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D405/06

Abstract: Compounds of general formula (1) are described, wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R6)-, where R6 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R?3 and R4¿, which may be the same or different, is each a group -(CH¿2?)nAr, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1, 2 or 3; R?5¿ is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent, selective and orally active PDE IV inhibitors and are useful in the prophylaxis and treatment of asthma and other diseases.

公开(公告)号：EP0382213B1

公开(公告)日：1995-05-10

申请号：EP90102488.5

申请日：1990-02-08

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Tanaka, Tatsuyoshi, 7-10 Nakanokoshi ,  Sakurai, Yoji, 59-3 Aza Seicho ,  Okazaki, Hiroshi, 57-1, Aza Hachikami ,  Hasegawa, Takashi, 86, Hoji, Aza Nagae ,  Fukuyama, Yoshiyasu

IPC: C07C39/21 ,  A61K31/05 ,  C07C39/15 ,  C07C39/367

CPC classification number: C07D207/26 ,  C07C39/15 ,  C07C39/21 ,  C07C39/367 ,  C07C43/1785 ,  C07C43/2055 ,  C07C43/215 ,  C07C43/23 ,  C07C43/253 ,  C07C43/295 ,  C07C45/46 ,  C07C46/02 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07C50/30 ,  C07C69/007 ,  C07C69/017 ,  C07C69/712 ,  C07C215/50 ,  C07C215/66 ,  C07C217/20 ,  C07C233/18 ,  C07C233/22 ,  C07C317/22 ,  C07C323/12 ,  C07C323/20 ,  C07D207/16 ,  C07D209/48 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/24 ,  C07D277/28 ,  C07D295/088 ,  C07D295/096 ,  C07D309/12

公开(公告)号：EP0486022A3

公开(公告)日：1993-01-13

申请号：EP91119451.2

申请日：1991-11-14

Applicant: Eisai Co., Ltd.

Inventor： Yoshimura, Hiroyuki ,  Abe, Shinya ,  Kawahara, Tetsuya ,  Shimomura, Naoyuki ,  Okano, Kazuo ,  Clark, Richard Steven John ,  Mori, Takashi ,  Miyazawa, Shuhei ,  Hashida, Ryoichi ,  Muramoto, Kenzo ,  Harada, Koukichi ,  Inoue, Takashi ,  Shirota, Hiroshi ,  Chiba, Kenichi ,  Kusube, Kenichi ,  Horie, Toru ,  Suzuki, Takeshi ,  Yamatsu, Isao

IPC: C07C59/64 ,  C07C59/52 ,  C07C59/90 ,  C07C39/40

CPC classification number: C07C255/41 ,  C07C39/40 ,  C07C43/202 ,  C07C43/23 ,  C07C43/253 ,  C07C45/00 ,  C07C47/575 ,  C07C59/52 ,  C07C59/64 ,  C07C59/72 ,  C07C59/90 ,  C07C69/734 ,  C07C69/738 ,  C07C251/48 ,  C07C2601/08

Abstract: The present invention concerns naphthalene derivatives of the formula:
with specific meanings for the substituents R 1 to R 4 and Y and Z. The above compounds are useful as medicaments for the treating of diseases resulting in an increased production of prostaglandin or leukotrines, for treating an inflammatory disease and for treating a disease selected from chronic rheumatoid arthritis, osteoarthritis, shoulder periarthritis, cervicobrachial syndrome and lumbago.

Abstract translation: 本发明涉及下式的萘衍生物：具有对取代基R 1至R 4以及Y和Z具有特定含义的下式：上述化合物可用作治疗导致产生增加的疾病的药物 的前列腺素或白细胞介素，用于治疗炎性疾病和治疗选自慢性类风湿性关节炎，骨关节炎，肩关节周围炎，子宫颈综合征和腰痛的疾病。

公开(公告)号：EP0313295A3

公开(公告)日：1990-07-11

申请号：EP88309721.4

申请日：1988-10-17

Applicant: PFIZER INC.

Inventor： Eggler, James Frederick ,  Marfat, Anthony ,  Melvin, Lawrence Sherman Jr.

IPC: C07D405/06 ,  C07D405/14 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D215/20 ,  C07D215/14 ,  C07D213/30 ,  C07C49/755 ,  C07C49/747 ,  C07D215/22

CPC classification number: C07D213/30 ,  C07C43/253 ,  C07C45/62 ,  C07C45/63 ,  C07C45/673 ,  C07C45/68 ,  C07C45/71 ,  C07C45/74 ,  C07C49/747 ,  C07C49/755 ,  C07D215/14 ,  C07D215/20 ,  C07D215/233 ,  C07D215/38 ,  C07D311/22 ,  C07D313/08 ,  C07D335/02 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, and intermediates useful in the synthesis thereof.

公开(公告)号：EP0343441A3

公开(公告)日：1990-05-09

申请号：EP89108533.4

申请日：1989-05-12

Applicant: BAYER AG

Inventor： Negele, Michael, Dr. ,  Bielefeldt, Dietmar, Dr. ,  Himmler, Thomas, Dr. ,  Marhold, Albrecht, Dr.

IPC: C07C43/247 ,  C07C323/00 ,  C07C47/55 ,  C07C205/00 ,  C07C217/00 ,  C07C43/225 ,  C07C69/767 ,  C07C63/74 ,  C07C265/00 ,  C07C69/94 ,  C07C65/28

CPC classification number: C07C309/42 ,  C07C43/247 ,  C07C43/253 ,  C07C45/71 ,  C07C47/575 ,  C07C49/84 ,  C07C65/28 ,  C07C205/36 ,  C07C205/37 ,  C07C217/84 ,  C07C233/25 ,  C07C255/54 ,  C07C265/12 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/16

Abstract: Neue fluorierte Bis-aryloxy-substituierte Alkene werden hergestellt durch Umsetzung von substituierten Phenolen mit Perhalogenalkenen und können als Elektroisolier­mittel verwendet werden.

Abstract translation: 新的氟化双芳氧基取代的烯烃通过取代的酚与全卤代烯烃的反应制备并可用作电绝缘剂。

公开(公告)号：EP2549863A4

公开(公告)日：2014-01-01

申请号：EP11760242

申请日：2011-03-24

Applicant: UNIV OHIO

Inventor： CHEN XIAOZHUO ,  BERGMEIER STEPHEN

IPC: A01N31/00 ,  A61K31/045

CPC classification number: C07C205/32 ,  A61K31/09 ,  A61K45/06 ,  C07C39/367 ,  C07C43/23 ,  C07C43/253 ,  C07C211/48 ,  C07C235/56 ,  C07D209/08 ,  C07D231/12 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D311/16 ,  C07D311/82 ,  C07D319/20

Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.

公开(公告)号：EP1553451A4

公开(公告)日：2009-12-16

申请号：EP03808872

申请日：2003-09-01

Applicant: IDEMITSU KOSAN CO

Inventor： UEDA MITSURU ,  ISHII HIROTOSHI

IPC: C07C43/253 ,  C07C69/712 ,  C07C69/736 ,  C07C69/96 ,  C07D309/04 ,  G03F7/004 ,  G03F7/039 ,  H01L21/027 ,  C07C39/17

CPC classification number: G03F7/0045 ,  C07C43/253 ,  C07C69/712 ,  C07C69/736 ,  C07C69/96 ,  C07C2603/74 ,  C07D309/04 ,  G03F7/0392