公开(公告)号：EP1506962A2

公开(公告)日：2005-02-16

申请号：EP04025700.8

申请日：2001-10-19

申请人： Eisai Co. Ltd.

发明人： Funahashi, Yasuhiro ,  Tsuruoka, Akihiko ,  Matsukura, Masayuki ,  Haneda, Toru ,  Fukuda, Yoshio ,  Kamata, Junichi ,  Takahashi, Keiko ,  Matsushima, Tomohiro ,  Miyazaki, Kazuki ,  Nomoto, Ken-ichi ,  Watanabe, Tatsuo ,  Obaishi, Hiroshi ,  Yamaguchi, Atsumi ,  Suzuki, Sachi ,  Nakamura, Katsuji ,  Mimura, Fusalo ,  Yamamoto, Yuji ,  Matsui, Junji ,  Matsui, Kenji ,  Yoshiba, Takako ,  Suzuki, Yasuyuki ,  Arimoto, Itaru

IPC分类号： C07D213/74 ,  C07D213/75 ,  C07D215/48 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/47 ,  A61P35/00

CPC分类号： C07D213/73 ,  A61K31/4706 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/519 ,  C07D207/34 ,  C07D213/26 ,  C07D213/68 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/18 ,  C07D215/233 ,  C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D239/34 ,  C07D239/42 ,  C07D239/47 ,  C07D239/88 ,  C07D249/04 ,  C07D261/14 ,  C07D277/48 ,  C07D307/68 ,  C07D319/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Compounds represented by the following general formula:
[wherein A g is an optionally substituted 5- to 14-membered heterocyclic group, etc.; X g is -O-, -S-, etc.; Y g is an optionally substituted C 6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and T g1 is a group represented by the following general formula:
(wherein E g is a single bond or -N(R g2 )-, R g1 and R g2 each independently represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, etc. and Z g represents a C 1-8 alkyl group, a C 3-8 alicyclic hydrocarbon group, a C 6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.

摘要翻译： 由以下通式表示的化合物：其中A是下式表示的另外任意取代的基团：其中X是氧原子，硫原子，-SO-或-SO 2; Y是任选取代的C 6-14芳基，任选取代的5至14元芳族杂环基或任选取代的C 1-6亚烷基; E是单键或-NR 2 - 。

公开(公告)号：EP1506962A3

公开(公告)日：2005-03-02

申请号：EP04025700.8

申请日：2001-10-19

申请人： Eisai Co. Ltd.

发明人： Funahashi, Yasuhiro ,  Tsuruoka, Akihiko ,  Matsukura, Masayuki ,  Haneda, Toru ,  Fukuda, Yoshio ,  Kamata, Junichi ,  Takahashi, Keiko ,  Matsushima, Tomohiro ,  Miyazaki, Kazuki ,  Nomoto, Ken-ichi ,  Watanabe, Tatsuo ,  Obaishi, Hiroshi ,  Yamaguchi, Atsumi ,  Suzuki, Sachi ,  Nakamura, Katsuji ,  Mimura, Fusalo ,  Yamamoto, Yuji ,  Matsui, Junji ,  Matsui, Kenji ,  Yoshiba, Takako ,  Suzuki, Yasuyuki ,  Arimoto, Itaru

IPC分类号： C07D213/74 ,  C07D213/75 ,  C07D215/48 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/47 ,  A61P35/00

CPC分类号： C07D213/73 ,  A61K31/4706 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/519 ,  C07D207/34 ,  C07D213/26 ,  C07D213/68 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D215/18 ,  C07D215/233 ,  C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D239/34 ,  C07D239/42 ,  C07D239/47 ,  C07D239/88 ,  C07D249/04 ,  C07D261/14 ,  C07D277/48 ,  C07D307/68 ,  C07D319/06 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： A compound represented by the following general formula: wherein A is a further optionally substituted group represented by the formula: X is an oxygen atom, a sulfur atom, -SO- or -SO 2 ; Y is an optionally substituted C 6-14 aryl group, an optionally substituted 5- to 14-membered aromatic heterocyclic group or an optionally substituted C 1-6 alkylene group; E is a single bond or -NR 2 -.

摘要翻译： 由下列通式表示的化合物：其中A为由下式表示的另外任选取代的基团：X为氧原子，硫原子，-SO-或-SO 2; Y是任选取代的C 6-14芳基，任选取代的5至14元芳族杂环基或任选取代的C 1-6亚烷基; E是单键或-NR 2 - 。

公开(公告)号：EP0472053A2

公开(公告)日：1992-02-26

申请号：EP91113256.1

申请日：1991-08-07

申请人： Eisai Co., Ltd.

发明人： Yoshino, Hiroshi ,  Ueda, Norihiro ,  Sgumi, Hiroyuki ,  Niijima, Jun ,  Kotake, Yoshihiko ,  Okada, Toshimi ,  Koyanagi, Nozomu ,  Watanabe, Tatsuo ,  Asada, Makoto ,  Yoshimatsu, Kentaro ,  Iijima, Atsumi ,  Nagasu, Takeshi ,  Tsukahara, Kappei ,  Kitoh, Kyosuke

IPC分类号： C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D213/74 ,  C07D239/48 ,  C07D239/50 ,  C07D239/42 ,  C07D333/38 ,  C07D307/68 ,  C07F9/58 ,  C07H15/203

CPC分类号： C07D213/74 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D239/42 ,  C07D239/48 ,  C07D239/50 ,  C07D307/68 ,  C07D333/38 ,  C07F9/588 ,  C07H15/203 ,  C07H15/26

摘要： To provide new sulfonamide derivatives having an excellent antitumor activity and only a low toxicity and a process for producing them.
Sulfonamide derivatives of the general formula (I):
wherein preferably R 1 represents a lower alkoxy group, R 2 , R 3 , R 4 , R 5 , R 6 and R 7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent = N- or = CH-, E represents an aromatic 6- membered cyclic group (which may have 1 or 2 nitrogen atoms in the ring) which may be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R 1 which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R 2 and R 3 which are each a hydrogen atom, A and B which are each = CH- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded, or pharmacologically acceptance salts of them.

摘要翻译： 提供具有优异的抗肿瘤活性和低毒性的新型磺酰胺衍生物及其生产方法。 通式（I）的磺酰胺衍生物：其中优选R 1表示低级烷氧基，R 2，R 3，R 4，R 5，R 6和 R 7可以相同或不同，各自表示氢原子，卤素原子或低级烷基，A和B可以相同或不同，各自表示= N-或= CH-， E表示芳族6元环基（其可以在环中具有1或2个氮原子），其可被1至3个可以彼此相同或不同的取代基取代，条件是R“ 1，其可以被保护的氢原子，低级烷基，硝基或氨基，R 2和R 3各自为氢原子，A和B各自为CH-和E， 是可以被1〜3个可以相同或不同的取代基G所取代的苯基，或它们的药理学接受盐。

公开(公告)号：EP0472053B1

公开(公告)日：1998-06-17

申请号：EP91113256.1

申请日：1991-08-07

申请人： Eisai Co., Ltd.

发明人： Yoshino, Hiroshi ,  Ueda, Norihiro ,  Sgumi, Hiroyuki ,  Niijima, Jun ,  Kotake, Yoshihiko ,  Okada, Toshimi ,  Koyanagi, Nozomu ,  Watanabe, Tatsuo ,  Asada, Makoto ,  Yoshimatsu, Kentaro ,  Iijima, Atsumi ,  Nagasu, Takeshi ,  Tsukahara, Kappei ,  Kitoh, Kyosuke

IPC分类号： C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D213/74 ,  C07D239/48 ,  C07D239/50 ,  C07D239/42 ,  C07D333/38 ,  C07D307/68 ,  C07F9/58 ,  C07H15/203

CPC分类号： C07D213/74 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D239/42 ,  C07D239/48 ,  C07D239/50 ,  C07D307/68 ,  C07D333/38 ,  C07F9/588 ,  C07H15/203 ,  C07H15/26

公开(公告)号：EP0472053A3

公开(公告)日：1994-08-10

申请号：EP91113256.1

申请日：1991-08-07

申请人： Eisai Co., Ltd.

发明人： Yoshino, Hiroshi ,  Ueda, Norihiro ,  Sgumi, Hiroyuki ,  Niijima, Jun ,  Kotake, Yoshihiko ,  Okada, Toshimi ,  Koyanagi, Nozomu ,  Watanabe, Tatsuo ,  Asada, Makoto ,  Yoshimatsu, Kentaro ,  Iijima, Atsumi ,  Nagasu, Takeshi ,  Tsukahara, Kappei ,  Kitoh, Kyosuke

IPC分类号： C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D213/74 ,  C07D239/48 ,  C07D239/50 ,  C07D239/42 ,  C07D333/38 ,  C07D307/68 ,  C07F9/58 ,  C07H15/203

CPC分类号： C07D213/74 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D239/42 ,  C07D239/48 ,  C07D239/50 ,  C07D307/68 ,  C07D333/38 ,  C07F9/588 ,  C07H15/203 ,  C07H15/26

摘要： To provide new sulfonamide derivatives having an excellent antitumor activity and only a low toxicity and a process for producing them. Sulfonamide derivatives of the general formula (I):
wherein preferably R 1 represents a lower alkoxy group, R 2 , R 3 , R 4 , R 5 , R 6 and R 7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent = N- or = CH-, E represents an aromatic 6- membered cyclic group (which may have 1 or 2 nitrogen atoms in the ring) which may be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R 1 which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R 2 and R 3 which are each a hydrogen atom, A and B which are each = CH- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded, or pharmacologically acceptance salts of them.