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1.发明授权
公开(公告)号：EP1254895B1
公开(公告)日：2007-05-23
申请号：EP01901413.3
申请日：2001-01-18
发明人： YAMAMOTO, Noboru , SUZUKI, Yuichi , KIMURA, Manami , NIIDOME, Tetsuhiro , IIMURA, Yoichi , TERAMOTO, Tetsuyuki , KANEDA, Yoshihisa , KANEKO, Toshihiko , KURUSU, Nobuyuki , SHINMYO, Daisuke , YOSHIKAWA, Yukie , HATAKEYAMA, Shinji
IPC分类号： C07D333/26 , A61K31/495 , A61K31/381 , A61P9/10
CPC分类号： C07D207/337 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/14 , C07D209/42 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/64 , C07D213/36 , C07D213/57 , C07D213/74 , C07D215/06 , C07D215/12 , C07D215/227 , C07D215/38 , C07D217/04 , C07D217/22 , C07D235/14 , C07D235/30 , C07D241/04 , C07D243/08 , C07D261/08 , C07D263/20 , C07D263/32 , C07D263/58 , C07D271/06 , C07D277/28 , C07D277/42 , C07D277/82 , C07D295/145 , C07D295/185 , C07D295/192 , C07D295/215 , C07D307/52 , C07D307/54 , C07D307/81 , C07D319/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/60 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D405/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D471/10 , C07D487/08
摘要： Novel compounds exhibiting excellent calcium antagonism, particularly neuroselective calcium antagonism, namely, compounds of the general formula (I), salts of the same, or hydrates of both wherein Ar is a group derived from an optionally substituted 5- to 14-membered aromatic ring, or the like; the ring A is one member selected from among piperazine, homopiperazine, piperidine and so on; the ring B is an optionally substituted C3-14 hydrocarbon ring or the like; E is a single bond, -CO-, or the like; X is a single bond, oxygen, or the like; R1 is hydrogen, halogeno, hydroxyl, or the like; and D?1, D2, W1 and W2¿ are each independently a single bond or optionally substituted C¿1-6? alkylene.
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2.发明授权N-ARYL-SUBSTITUTED CYCLIC AMINE DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT 有权N-芳基取代的环胺衍生物与医学认为本作为活性成分的
公开(公告)号：EP1375496B1
公开(公告)日：2007-07-04
申请号：EP02707189.3
申请日：2002-03-27
发明人： OKADA, Toshimi , KURUSU, Nobuyuki , TANAKA, Keigo , YOSHIKAWA, Seiji , SHINMYO, Daisuke , WATANABE, Nobuhisa , IKUTA, Hironori , HIYOSHI, Hironobu , SAEKI, Takao , YANAGIMACHI, Mamoru , ITO, Masashi
IPC分类号： C07D401/04 , C07D401/14 , C07D451/14 , C07D453/02 , C07D491/113 , A61K31/435 , A61K31/439
CPC分类号： C07D401/04 , A61K31/435 , A61K31/439 , A61K31/4545 , C07D401/14 , C07D453/04 , C07D491/10
摘要： A compound having excellent squalene synthetase inhibitory activity. It is a compound (I) represented by the following general formula, a salt thereof, or a hydrate of either. (I) In the formula, R1 means optionally substituted vinyl or an optionally substituted aromatic ring; n is an integer of 0 to 2; X, Y, and Z are the same or different and each means optionally substituted carbon, nitrogen, etc.; CyA means an optionally substituted 5- to 14-membered nonaromatic cyclic amino group optionally containing oxygen or sulfur; W means -C=C-, etc.; and A means a group of the formula (II) (wherein R8 represents hydrogen, hydroxy, etc.; B2 represents optionally substituted carbon or nitrogen; and c is 0 or 1), etc.
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公开(公告)号：EP2181992B8
公开(公告)日：2013-06-26
申请号：EP08828870.9
申请日：2008-08-28
发明人： KIMURA, Teiji , KITAZAWA, Noritaka , KANEKO, Toshihiko , SATO, Nobuaki , KAWANO, Koki , ITO, Koichi , TAKAISHI, Mamoru , SASAKI, Takeo , YOSHIDA, Yu , UEMURA, Toshiyuki , DOKO, Takashi , SHINMYO, Daisuke , HASEGAWA, Daiju , MIYAGAWA, Takehiko , HAGIWARA, Hiroaki
IPC分类号： C07D403/10 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/522 , A61K31/5383 , A61K31/5517 , A61P25/00 , A61P25/28 , A61P43/00 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D403/10 , C07D471/04 , C07D487/04 , C07D498/04
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4.发明授权NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS 有权含氮缩合杂环化合物及其作为β淀粉样蛋白生成抑制剂
公开(公告)号：EP2401276B1
公开(公告)日：2013-06-05
申请号：EP10708824.7
申请日：2010-02-24
发明人： KITAZAWA, Noritaka , SHINMYO, Daisuke , ITO, Koichi , SATO, Nobuaki , HASEGAWA, Daiju , UEMURA, Toshiyuki , WATANABE, Toru
IPC分类号： C07D471/04 , A61K31/4439 , C07D471/18 , C07D487/04 , C07D498/04 , C07D417/14
CPC分类号： C07D417/14 , C07D471/04 , C07D471/18 , C07D487/04 , C07D498/04
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公开(公告)号：EP2181992B1
公开(公告)日：2013-05-01
申请号：EP08828870.9
申请日：2008-08-28
发明人： KIMURA, Teiji , KITAZAWA, Noritaka , KANEKO, Toshihiko , SATO, Nobuaki , KAWANO, Koki , ITO, Koichi , TAKAISHI, Mamoru , SASAKI, Takeo , YOSHIDA, Yu , UEMURA, Toshiyuki , DOKO, Takashi , SHINMYO, Daisuke , HASEGAWA, Daiju , MIYAGAWA, Takehiko , HAGIWARA, Hiroaki
IPC分类号： C07D403/10 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/522 , A61K31/5383 , A61K31/5517 , A61P25/00 , A61P25/28 , A61P43/00 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D403/10 , C07D471/04 , C07D487/04 , C07D498/04
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6.发明公开NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS 有权含氮缩合杂环化合物及其作为β淀粉样蛋白生成抑制剂
公开(公告)号：EP2401276A1
公开(公告)日：2012-01-04
申请号：EP10708824.7
申请日：2010-02-24
发明人： KITAZAWA, Noritaka , SHINMYO, Daisuke , ITO, Koichi , SATO, Nobuaki , HASEGAWA, Daiju , UEMURA, Toshiyuki , WATANABE, Toru
IPC分类号： C07D471/04 , A61K31/4439 , C07D471/18 , C07D487/04 , C07D498/04 , C07D417/14
CPC分类号： C07D417/14 , C07D471/04 , C07D471/18 , C07D487/04 , C07D498/04
摘要： A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
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公开(公告)号：EP2181992A1
公开(公告)日：2010-05-05
申请号：EP08828870.9
申请日：2008-08-28
发明人： KIMURA, Teiji , KITAZAWA, Noritaka , KANEKO, Toshihiko , SATO, Nobuaki , KAWANO, Koki , ITO, Koichi , TAKAISHI, Mamoru , SASAKI, Takeo , YOSHIDA, Yu , UEMURA, Toshiyuki , DOKO, Takashi , SHINMYO, Daisuke , HASEGAWA, Daiju , MIYAGAWA, Takehiko , HAGIWARA, Hiroaki
IPC分类号： C07D403/10 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/522 , A61K31/5383 , A61K31/5517 , A61P25/00 , A61P25/28 , A61P43/00 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D403/10 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Disclosed is a compound represented by the formula (I):
or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by Aβ, wherein Ar 1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar 2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X 1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.摘要翻译： 公开了由式（I）表示的化合物或其药理学上可接受的盐，其作为A 2诱导的疾病的治疗或预防剂是有效的，其中Ar 1表示可被C1- 6烷基等; Ar 2表示可被C 1-6烷氧基取代的苯基等; X 1表示双键等; Het表示可以被C 1-6烷基等取代的三唑基等。
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