公开(公告)号：EP3868838A3

公开(公告)日：2021-11-24

申请号：EP21154523.1

申请日：2021-02-01

申请人： Eisai R&D Management Co., Ltd. ,  SYSMEX CORPORATION

发明人： Hara, Daiki ,  Motoki, Takafumi ,  Kazuta, Yuji ,  Norimine, Yoshihiko ,  Amino, Hiroyuki ,  Suganuma, Masatoshi ,  Fujiyama, Shingo ,  Yamashita, Kazuto ,  Okada, Masaya ,  Nishikawa, Yoichi ,  Iwanaga, Shigeki

IPC分类号： C09B69/00 ,  C09B11/28 ,  C12Q1/6816 ,  G01N33/58 ,  C07F7/08 ,  G01N21/64

摘要： Disclosed is: a fluorescent dye consisting of a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy. The fluorescent dye has formula (I):

wherein A represents an optionally substituted C4-C7 heterocyclic ring which contains an Si atom.

公开(公告)号：EP3868838A2

公开(公告)日：2021-08-25

申请号：EP21154523.1

申请日：2021-02-01

申请人： Eisai R&D Management Co., Ltd. ,  SYSMEX CORPORATION

发明人： Hara, Daiki ,  Motoki, Takafumi ,  Kazuta, Yuji ,  Norimine, Yoshihiko ,  Amino, Hiroyuki ,  Suganuma, Masatoshi ,  Fujiyama, Shingo ,  Yamashita, Kazuto ,  Okada, Masaya ,  Nishikawa, Yoichi ,  Iwanaga, Shigeki

IPC分类号： C09B69/00 ,  C09B11/28 ,  C12Q1/6816 ,  G01N33/58 ,  C07F7/08 ,  G01N21/64

摘要： Disclosed is: a fluorescent dye consisting of a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy. The fluorescent dye has formula (I):

wherein A represents an optionally substituted C4-C7 heterocyclic ring which contains an Si atom.

公开(公告)号：EP4053842A1

公开(公告)日：2022-09-07

申请号：EP22160175.0

申请日：2022-03-04

申请人： SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  National Institute Of Advanced Industrial Science and Technology

发明人： Okada, Masaya ,  Shimaoka, Yuki ,  Iwanaga, Shigeki ,  Bando, Kazuki ,  Fujita, Katsumasa ,  Nawa, Yasunori ,  Fujita, Satoshi

IPC分类号： G16C20/20

摘要： Disclosed is an analytical method for analyzing a test substance contained in a measurement sample, the method comprising: generating a data set based on a plurality of optical spectra acquired from a plurality of locations in the measurement sample; inputting the data set into a deep learning algorithm having a neural network structure; and outputting information on the test substance, on the basis of an analytical result from the deep learning algorithm.

公开(公告)号：EP4053556A1

公开(公告)日：2022-09-07

申请号：EP22160173.5

申请日：2022-03-04

申请人： SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  National Institute Of Advanced Industrial Science and Technology

发明人： Shimaoka, Yuki ,  Okada, Masaya ,  Iwanaga, Shigeki ,  Bando, Kazuki ,  Fujita, Katsumasa ,  Nawa, Yasunori ,  Fujita, Satoshi

IPC分类号： G01N33/543

摘要： Disclosed is a preparation method for preparing a measurement sample comprising an aggregate of metal nanoparticles having an analyte bound thereto, the preparation method comprising: contacting the analyte with a linker to bind the analyte to the linker; and contacting the linker that has been bound to the analyte with the metal nanoparticles to bind the linker to the metal nanoparticles.

公开(公告)号：EP3217206A1

公开(公告)日：2017-09-13

申请号：EP17160079.4

申请日：2017-03-09

申请人： SYSMEX CORPORATION

发明人： Okada, Masaya ,  Iwanaga, Shigeki

IPC分类号： G02B21/00

CPC分类号： G02B27/0068 ,  G01N21/6458 ,  G02B21/0056 ,  G02B21/0064 ,  G02B21/0076

摘要： An optical device comprises a shared phase modulation mask configured to impart a first phase modulation to light of a first wavelength, and imparts a second phase modulation to light of a second wavelength, an irradiation optical system configured to cause the light of the first wavelength and the light of the second wavelength to enter the same incident region in the phase modulation mask, and a light collecting optical system configured to collect the light of the first phase-modulated first wavelength and the light of the second phase-modulated second wavelength to form an image corresponding to a point spread function.

摘要翻译： 一种光学器件，包括：共享相位调制掩模，被配置为对第一波长的光施加第一相位调制，并且对第二波长的光赋予第二相位调制;照射光学系统，被配置为引起第一波长的光;以及 第二波长的光进入相位调制掩模中的相同入射区域;以及光收集光学系统，配置为收集第一相位调制的第一波长的光和第二相位调制的第二波长的光以形成 对应于点扩散函数的图像。

公开(公告)号：EP4030169A1

公开(公告)日：2022-07-20

申请号：EP22151534.9

申请日：2022-01-14

申请人： Sysmex Corporation

发明人： Miura, Masahiro ,  Akama, Kenji ,  Kawai, Masaaki ,  Okada, Masaya ,  Shirai, Kentaro ,  Yoshida, Yuichiro ,  Yotoriyama, Tasuku ,  Notoya, Michitaka ,  Oue, Soichi

IPC分类号： G01N35/00 ,  C12Q1/6844

摘要： PROBLEM TO BE SOLVED: To provide a nucleic acid analysis method capable of reducing reagent cost and improving throughput while guaranteeing the accuracy of nucleic acid analysis. SOLUTION: In a diffusion analysis method, which is an example of an embodiment, a first sample set is prepared that includes a test sample prepared from a first subject sample and a reagent, and at least one control sample prepared from at least one of a positive control and a negative control, and a second sample set is prepared that includes a test sample prepared from a second subject sample and a reagent and does not contain at least one of the control samples contained in the first sample set. The nucleic acid amplification in the first sample set is measured in the first unit, the nucleic acid amplification in the second sample set is measured in the second unit, and the measurement result of each test sample contained in the first sample set and second sample set is analyzed based on the measurement result of the control sample contained in at least the first sample set.

公开(公告)号：EP3188125B1

公开(公告)日：2020-10-07

申请号：EP16205768.1

申请日：2016-12-21

申请人： SYSMEX CORPORATION ,  National University Corporation Tokyo Medical and Dental University

发明人： Hakamada, Kazumi ,  Aihara, Yuki ,  Okada, Masaya ,  Sato, Toshiyuki ,  Sekiya, Ichiro ,  Kobayashi, Eiji

IPC分类号： G06T5/50

公开(公告)号：EP3640702A2

公开(公告)日：2020-04-22

申请号：EP19200083.4

申请日：2019-09-27

申请人： SYSMEX CORPORATION

发明人： Okada, Masaya ,  Iwanaga, Shigeki

IPC分类号： G02B21/16 ,  G02B21/24 ,  G02B21/36 ,  G02B21/00 ,  G02B21/08 ,  G02B21/14

摘要： A microscope apparatus is provided with: a sample setting unit in which a sample is set; an imaging unit configured to image the sample set in the sample setting unit; a housing unit on which the sample setting unit is arranged, and which is configured to internally accommodate the imaging unit; a first light source configured to irradiate light for fluorescence excitation on the sample in the sample setting unit; a first cover configured to be movable to a first position that covers the sample setting unit and a second position that opens the sample setting unit; and a second cover configured to be movable within the first cover so as to be in a closed state that covers the sample setting unit and an open state that opens the sample setting unit; and a second light source arranged in a space covered with the second cover and configured to irradiate light on the sample in the sample setting unit.

公开(公告)号：EP3640702A3

公开(公告)日：2020-08-26

申请号：EP19200083.4

申请日：2019-09-27

申请人： SYSMEX CORPORATION

发明人： Okada, Masaya ,  Iwanaga, Shigeki

IPC分类号： G02B21/16 ,  G02B21/24 ,  G02B21/36 ,  G02B21/00 ,  G02B21/08 ,  G02B21/14

摘要： A microscope apparatus is provided with: a sample setting unit in which a sample is set; an imaging unit configured to image the sample set in the sample setting unit; a housing unit on which the sample setting unit is arranged, and which is configured to internally accommodate the imaging unit; a first light source configured to irradiate light for fluorescence excitation on the sample in the sample setting unit; a first cover configured to be movable to a first position that covers the sample setting unit and a second position that opens the sample setting unit; and a second cover configured to be movable within the first cover so as to be in a closed state that covers the sample setting unit and an open state that opens the sample setting unit; and a second light source arranged in a space covered with the second cover and configured to irradiate light on the sample in the sample setting unit.

公开(公告)号：EP3396381A1

公开(公告)日：2018-10-31

申请号：EP18166773.4

申请日：2018-04-11

申请人： SYSMEX CORPORATION

发明人： Akama, Kenji ,  Watanabe, Toshihiro ,  Okada, Masaya ,  Yamashita, Kazuto ,  Ganguly, Akshay ,  Iwanaga, Shigeki

IPC分类号： G01N33/68 ,  G01N33/543 ,  G01N33/58 ,  G01N21/64

CPC分类号： G01N33/54326 ,  C07K16/18 ,  C07K2317/70 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/533 ,  G01N33/54353 ,  G01N33/5436 ,  G01N33/54366 ,  G01N33/582 ,  G01N33/6896 ,  G01N2333/4709

摘要： Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.