公开(公告)号：EP3188125B1

公开(公告)日：2020-10-07

申请号：EP16205768.1

申请日：2016-12-21

申请人： SYSMEX CORPORATION ,  National University Corporation Tokyo Medical and Dental University

发明人： Hakamada, Kazumi ,  Aihara, Yuki ,  Okada, Masaya ,  Sato, Toshiyuki ,  Sekiya, Ichiro ,  Kobayashi, Eiji

IPC分类号： G06T5/50

公开(公告)号：EP3188125A1

公开(公告)日：2017-07-05

申请号：EP16205768.1

申请日：2016-12-21

申请人： SYSMEX CORPORATION ,  National University Corporation Tokyo Medical and Dental University

发明人： Hakamada, Kazumi ,  Aihara, Yuki ,  Okada, Masaya ,  Sato, Toshiyuki ,  Sekiya, Ichiro ,  Kobayashi, Eiji

IPC分类号： G06T5/50

摘要： A method comprises obtaining a first cell image of a cell by a first observation method, obtaining a second cell image of the cell by a second observation method that is different from the first observation method, and determining the region of the cell based on the first cell image and the second cell image.

摘要翻译： 一种方法包括：通过第一观察方法获得细胞的第一细胞图像，通过不同于第一观察方法的第二观察方法获得细胞的第二细胞图像，以及基于第一观察方法确定细胞的区域 细胞图像和第二细胞图像。

公开(公告)号：EP2198774B1

公开(公告)日：2018-09-26

申请号：EP09015799.1

申请日：2009-12-21

申请人： SYSMEX CORPORATION

发明人： Okada, Seiki ,  Asakura, Yoshihiro ,  Sato, Toshiyuki ,  Hagino, Kei ,  Kojima, Junko ,  Kikkawa, Yasuo

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC分类号： A61B5/14532 ,  A61B5/14514 ,  A61B5/14865 ,  A61B5/7242 ,  A61B2562/0295

摘要： An in vivo component measurement method comprises steps of: extracting a tissue fluid from a biological body into an extraction medium and accumulating an objective component and an inorganic ion in the extracted tissue fluid; acquiring ion information on a quantity of the accumulated inorganic ion; acquiring a component information on a quantity of the accumulated objective component; and acquiring an analysis value on the quantity of the objective component based on the ion information and the component information.

公开(公告)号：EP3138491A1

公开(公告)日：2017-03-08

申请号：EP16186294.1

申请日：2016-08-30

申请人： SYSMEX CORPORATION ,  Mie University

发明人： Suminaka, Chihiro ,  Sato, Toshiyuki ,  Yano, Yutaka ,  Suzuki, Toshinari ,  Uemura, Mei

IPC分类号： A61B5/145 ,  A61B5/1486

CPC分类号： G01N27/3272 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1486 ,  A61B10/0233 ,  C12Q1/006 ,  G01N27/3273 ,  G01N33/49

摘要： Disclosed is a method for analyzing a concentration state of a measurement target component in blood, the method including: obtaining a value regarding an amount of the measurement target component in a collection member in which tissue fluid has been accumulated in advance, the tissue fluid having been extracted for a predetermined extraction time period from an organism which had been subjected to a process for accelerating the extraction of the tissue fluid; obtaining a value of an area under a blood concentration time curve of the measurement target component on the basis of the value regarding the amount of the measurement target component; and calculating a value regarding a ratio of a time period during which a concentration of the measurement target component has exceeded a predetermined concentration relative to the extraction time period, on the basis of the value of the area under the blood concentration time curve.

摘要翻译： 本发明公开了一种分析血液中的测定对象成分的浓度状态的方法，其特征在于，包括：获取关于预先组织液积聚的收集部件中的测定对象成分的量的值，所述组织液具有 从已经进行加速组织液提取的过程的生物体提取预定的提取时间段; 根据与测定对象成分量相关的值，求出测定对象成分的血液浓度时间曲线下面积的值; 基于血液浓度时间曲线下的面积的值，计算出测定对象成分的浓度相对于提取时间段超过预定浓度的时间段的比值。

公开(公告)号：EP2302544A3

公开(公告)日：2016-09-21

申请号：EP10175561.9

申请日：2010-09-07

申请人： SYSMEX CORPORATION

发明人： Okada, Seiki ,  Sato, Toshiyuki ,  Yamada, Kaya ,  Seko, Akinobu ,  Nakamura, Teiji ,  Totsuka, Sachi

IPC分类号： G06F19/00

CPC分类号： G06F19/3475 ,  G06F19/00 ,  G06F19/3456 ,  G16H15/00

摘要： A postprandial blood glucose estimating apparatus for estimating a value related to postprandial blood glucose of a subject, comprising: an input receiving part for receiving an input of information relating to an amount of energy in a food belonging to carbohydrate-containing food group which contains carbohydrates, and information relating to an amount of energy in a food belonging to a first food group that is different from the carbohydrate-containing food group; and an estimating part for estimating a value related to a postprandial glucose level when the subject consumes the food belonging to the carbohydrate-containing food group and the food belonging to the first food group, based on the information relating to the amount of energy in the food belonging to the carbohydrate-containing food group and the information relating to the amount of energy in the food belonging to the first food group, is disclosed.

公开(公告)号：EP2937415A1

公开(公告)日：2015-10-28

申请号：EP15161821.2

申请日：2015-03-31

申请人： SYSMEX CORPORATION

发明人： Kobayashi, Eiji ,  Sato, Toshiyuki ,  Akama, Kenji ,  Hori, Nobuyasu ,  Shibayama, Masaki ,  Aihara, Yuki ,  Kadowaki, Masakazu

IPC分类号： C12N5/078 ,  C12N5/0775 ,  A01N1/02 ,  C12M3/00

CPC分类号： C12N5/0644 ,  A01N1/0247 ,  C12N5/0603 ,  C12N5/0607 ,  C12N5/0652 ,  C12N5/0663 ,  C12N5/0679 ,  C12N5/0696 ,  C12N2506/11 ,  C12N2506/1353

摘要： Disclosed is a method for obtaining differentiated cells and/or differentiated cell products, including the steps of: introducing undifferentiated cells into a perfused organ or living tissue; subjecting the undifferentiated cells to perfusion culture together with the organ or living tissue so as to allow the undifferentiated cells to differentiate; collecting a perfusion culture solution that contains the resulting differentiated cells and/or differentiated cell products; and obtaining the differentiated cells and/or differentiated cell products contained in the collected perfusion culture solution.

摘要翻译： 公开了一种用于获得分化的细胞和/或分化的细胞产物，包括以下步骤的方法：将未分化细胞成灌注器官或活组织; 与器官对所述未分化的细胞，以灌注培养一起或活组织，以便允许未分化细胞分化; 收集灌注培养液做包含所得分化细胞和/或分化的细胞制品; 以及获得所述分化的细胞和/或包含在所收集的灌注培养溶液分化细胞产品。

公开(公告)号：EP2238891A1

公开(公告)日：2010-10-13

申请号：EP10158110.6

申请日：2010-03-29

申请人： SYSMEX CORPORATION

发明人： Sato, Toshiyuki ,  Okada, Seiki

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/14514

摘要： The invention provides A method for predicting a concentration fluctuation of a measurement target component in the blood, comprising steps of: obtaining an initial value of the amount relating to the measurement target component in a subject (S0); obtaining, as a first measurement value, a value of an area under the blood concentration time curve of the measurement target component during a first extraction period (S2,S3,S4,S9); obtaining, as a second measurement value, a value of an area under the blood concentration time curve of the measurement target component during a second extraction period (S6,S7,S8,S9); and predicting the concentration fluctuation of the measurement target component in the blood from the initial value, the first measurement value and the second measurement value (S10,S11), as well as a device for predicting a concentration fluctuation of a measurement target component in the blood.

摘要翻译： 本发明提供了在血液中预测的测量对象成分的浓度波动，包括​​以下步骤的方法：在被检体（S0）与测定对象成分的量的初始值的获取; 获得，作为第一测量值，所述测定对象成分的血中浓度时间曲线下的区域的在第一提取周期（S2，S3，S4，S9）的值; 获得，作为第二测量值，所述测定对象成分的血中浓度时间曲线下的区域的过程中的第二提取周期（S6，S7，S8，S9）的值; 和预测在从初始值，所述第一测量值和第二测量值（S10，S11）的血液中的测定对象成分的浓度波动，以及用于在预测的测量对象成分的浓度波动的装置 血。

公开(公告)号：EP2937415B1

公开(公告)日：2018-11-21

申请号：EP15161821.2

申请日：2015-03-31

申请人： SYSMEX CORPORATION

发明人： Kobayashi, Eiji ,  Sato, Toshiyuki ,  Akama, Kenji ,  Hori, Nobuyasu ,  Shibayama, Masaki ,  Aihara, Yuki ,  Kadowaki, Masakazu

IPC分类号： C12N5/078 ,  C12N5/0775 ,  A01N1/02 ,  C12M3/00 ,  C12N5/071

CPC分类号： C12N5/0644 ,  A01N1/0247 ,  C12N5/0603 ,  C12N5/0607 ,  C12N5/0652 ,  C12N5/0663 ,  C12N5/0679 ,  C12N5/0696 ,  C12N2506/11 ,  C12N2506/1353

摘要： Disclosed is a method for obtaining differentiated cells and/or differentiated cell products, including the steps of: introducing undifferentiated cells into a perfused organ or living tissue; subjecting the undifferentiated cells to perfusion culture together with the organ or living tissue so as to allow the undifferentiated cells to differentiate; collecting a perfusion culture solution that contains the resulting differentiated cells and/or differentiated cell products; and obtaining the differentiated cells and/or differentiated cell products contained in the collected perfusion culture solution.

公开(公告)号：EP2399519A1

公开(公告)日：2011-12-28

申请号：EP11170507.5

申请日：2011-06-20

申请人： SYSMEX CORPORATION

发明人： Kikkawa, Yasuo ,  Sato, Toshiyuki

IPC分类号： A61B5/151

CPC分类号： A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150717 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194

摘要： To provide a micropore forming apparatus capable of increasing the amount of interstitial fluid extracted from micropores formed in the skin of a subject. The micropore forming apparatus includes a skin contact part that has a plurality of microneedles for piercing the skin of the subject, and a force exerting means for exerting a force on the skin contact part toward the skin of the subject. The force exerting means is configured so as to exert a force on the microneedles toward the skin at a position at which the microneedles of the skin contact part are to pierce the skin of the subject.

公开(公告)号：EP2233068A1

公开(公告)日：2010-09-29

申请号：EP10156880.6

申请日：2010-03-18

申请人： SYSMEX CORPORATION

发明人： Asakura, Yoshihiro ,  Sato, Toshiyuki ,  Okada, Seiki ,  Tarutani, Jun ,  Endo, Chika

IPC分类号： A61B5/00 ,  A61B5/151

CPC分类号： A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150358 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/157 ,  A61B2562/0295

摘要： A puncture device (1) which punctures a skin of a subject for extracting a tissue fluid from a puncture site of the subject. The puncture device included a timer (140); a notifying section which notifies a user that specific time measured by the time has passed; a puncture mechanism which punctuates the skin; and an interlock mechanism which caused the timer to start time measurement in conjunction with a punctuate action by the puncture mechanism.

摘要翻译： 1.一种穿刺装置（1），其从被检体的穿刺部位刺穿被检体的皮肤，以从组织液中提取组织液。 穿刺装置包括定时器（140）; 通知部，其通知用户通过时间测量的具体时间; 刺穿皮肤的穿刺机构; 以及联锁机构，其使定时器与穿刺机构的标点动作结合起始时间测量。