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1.发明公开COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS 审中-公开组合物和方法与PROTEINASEAKTIVIERTEN受体拮抗剂
公开(公告)号：EP1778652A2
公开(公告)日：2007-05-02
申请号：EP05791547.2
申请日：2005-08-19
申请人： EntreMed, Inc.
发明人： AGOSTON, Gregory, E. , HEMBROUGH, Todd, A. , LAVALLEE, Theresa, M. , SHAH, Jamshed, H. , SUWANDI, Lita , TRESTON, Anthony, M.
IPC分类号： C07D261/18 , C07D235/30 , C07D403/02
CPC分类号： C07D295/185 , C07D205/04 , C07D207/34 , C07D213/56 , C07D213/82 , C07D231/40 , C07D233/64 , C07D235/26 , C07D235/30 , C07D241/26 , C07D249/04 , C07D261/18 , C07D275/03 , C07D277/46 , C07D403/06 , C07D487/04
摘要： Compositions and methods comprising proteinase activated receptor antagonists are provided. More particularly, the present invention relates to the use of proteins, peptides and molecules that bind to proteinase activated receptor 2, and inhibit the processes associated with the activation of that receptor. More specifically, the present invention provides novel compositions and methods for the treatment of disorders and diseases such as those associated with abnormal cellular proliferation, angiogenesis, inflammation and cancer.
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公开(公告)号：EP1756139A2
公开(公告)日：2007-02-28
申请号：EP05736385.5
申请日：2005-03-11
发明人： AGOSTON, Gregory, E. , SHAH, Jamshed, H. , SUWANDI, Lita , LAVALLEE, Theresa, M. , TRESTON, Anthony
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formula I (I), or formula II (II), wherein Ra is selected from -OCH3, OCH2CH3 or -CCCH3; and Z is selected from >C(H)-OH, >C(H)-O-alkyl, >C(H)-O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
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公开(公告)号：EP1633367A2
公开(公告)日：2006-03-15
申请号：EP04809420.5
申请日：2004-05-28
申请人： EntreMed, Inc.
发明人： AGOSTON, Gregory, E , LAVALLEE, Theresa, M. , PRIBLUDA, Victor, S. , SHAH, Jamshed, H. , TRESTON, Anthony, M.
CPC分类号： C07J41/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula (I) wherein the variables are defined in the specification.
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公开(公告)号：EP1343803A2
公开(公告)日：2003-09-17
申请号：EP01968112.1
申请日：2001-08-24
申请人： EntreMed, Inc.
发明人： AGOSTON, Gregory , SHAH, Jamshed, H. , HUNSUCKER, Kimberly, A. , PRIBLUDA, Victor , LAVALLEE, Theresa, M. , GREEN, Shawn, J. , HERBSTRITT, Christopher, J. , ZHAN, Xiaoguo, H. , TRESTON, Anthony
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula (I), wherein the variables are defined in the specification.
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