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1.发明授权METHODS AND NUCLEIC ACIDS FOR ANALYSES OF COLORECTAL CELL PROLIFERATIVE DISORDERS 有权方法和核酸是否存在问题在大肠癌细胞的增殖分析
公开(公告)号：EP1636386B1
公开(公告)日：2015-08-05
申请号：EP04777046.6
申请日：2004-06-23
申请人： Epigenomics AG
发明人： LOFTON-DAY, Cathy , MODEL, Fabian , SLEDZIEWSKI, Andrew , RUJAN, Tamas , LEWIN, Jörn , DISTLER, Juergen
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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2.发明公开
公开(公告)号：EP1478778A2
公开(公告)日：2004-11-24
申请号：EP03714760.0
申请日：2003-02-27
申请人： Epigenomics AG
发明人： ADORJAN, Peter , BURGER, Matthias , MAIER, Sabine , NIMMRICH, Inko , BECKER, Evelyne , LESCHE, Ralf , RUJAN, Tamas , SCHMITT, Armin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
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3.发明公开
公开(公告)号：EP1554407A2
公开(公告)日：2005-07-20
申请号：EP03808704.5
申请日：2003-10-01
申请人： Epigenomics AG
发明人： FOEKENS, John , HARBECK, Nadia , KÖNIG, Thomas , MAIER, Sabine , MARTENS, John , MODEL, Fabian , NIMMRICH, Inko , RUJAN, Tamas , SCHMITT, Armin , SCHMITT, Manfred , LOOK, Maxime, P. , MARX, Almuth , HÖFLER, Heinz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
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4.发明公开METHODS AND NUCLEIC ACIDS FOR ANALYSES OF COLORECTAL CELL PROLIFERATIVE DISORDERS 有权方法和核酸是否存在问题在大肠癌细胞的增殖分析
公开(公告)号：EP1636386A2
公开(公告)日：2006-03-22
申请号：EP04777046.6
申请日：2004-06-23
申请人： Epigenomics AG
发明人： LOFTON-DAY, Cathy , MODEL, Fabian , SLEDZIEWSKI, Andrew , RUJAN, Tamas , LEWIN, Jörn , DISTLER, Juergen
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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公开(公告)号：EP1525328A1
公开(公告)日：2005-04-27
申请号：EP03784164.0
申请日：2003-08-01
申请人： Epigenomics AG
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2600/156
摘要： The invention describes a method for amplifying nucleic acids, such as DNA with means of an enzymatic amplification step, such as a polymerase chain reaction, specified for template nucleic acids of low complexity, e.g. pre-treated DNA, like but not limited to DNA pre-treated with bisulfite is disclosed. The invention is based on the use of specific oligo-nucleotide primer molecules to solely amplify specific pieces of DNA. It is disclosed how to optimize the primer design for a PCR if the template DNA is of low complexity.
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公开(公告)号：EP1525328B1
公开(公告)日：2010-01-20
申请号：EP03784164.0
申请日：2003-08-01
申请人： Epigenomics AG
CPC分类号： C12Q1/6858 , C12Q2600/156
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公开(公告)号：EP1554407B1
公开(公告)日：2009-07-29
申请号：EP03808704.5
申请日：2003-10-01
申请人： Epigenomics AG
发明人： FOEKENS, John , HARBECK, Nadia , KÖNIG, Thomas , MAIER, Sabine , MARTENS, John , MODEL, Fabian , NIMMRICH, Inko , RUJAN, Tamas , SCHMITT, Armin , SCHMITT, Manfred , LOOK, Maxime, P. , MARX, Almuth , HÖFLER, Heinz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
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8.发明授权
公开(公告)号：EP1478778B1
公开(公告)日：2009-05-13
申请号：EP03714760.0
申请日：2003-02-27
申请人： Epigenomics AG
发明人： ADORJAN, Peter , BURGER, Matthias , MAIER, Sabine , NIMMRICH, Inko , BECKER, Evelyne , LESCHE, Ralf , RUJAN, Tamas , SCHMITT, Armin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
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9.发明公开EPIGENETIC METHODS AND NUCLEIC ACIDS FOR THE DETECTION OF LUNG CELL PROLIFERATIVE DISORDERS 审中-公开表观遗传学方法和核酸对肺癌细胞增殖紊乱的检测
公开(公告)号：EP1812589A2
公开(公告)日：2007-08-01
申请号：EP05789981.7
申请日：2005-09-30
申请人： Epigenomics AG
发明人： PLUM, Achim , RUJAN, Tamas , MAIER, Sabine , LESCHE, Ralf , GRAHAM, Alexander , SOUTH, Marie , BAILEY IACONA, Rennee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/16 , C12Q2531/113 , C12Q2523/125
摘要： The invention provides methods, nucleic acids and kits for detecting, classifying and/or distinguishing between or among lung cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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