公开(公告)号：EP1554407B1

公开(公告)日：2009-07-29

申请号：EP03808704.5

申请日：2003-10-01

申请人： Epigenomics AG

发明人： FOEKENS, John ,  HARBECK, Nadia ,  KÖNIG, Thomas ,  MAIER, Sabine ,  MARTENS, John ,  MODEL, Fabian ,  NIMMRICH, Inko ,  RUJAN, Tamas ,  SCHMITT, Armin ,  SCHMITT, Manfred ,  LOOK, Maxime, P. ,  MARX, Almuth ,  HÖFLER, Heinz

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.

公开(公告)号：EP1478778B1

公开(公告)日：2009-05-13

申请号：EP03714760.0

申请日：2003-02-27

申请人： Epigenomics AG

发明人： ADORJAN, Peter ,  BURGER, Matthias ,  MAIER, Sabine ,  NIMMRICH, Inko ,  BECKER, Evelyne ,  LESCHE, Ralf ,  RUJAN, Tamas ,  SCHMITT, Armin

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/154 ,  Y10T436/143333

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.

公开(公告)号：EP1554407A2

公开(公告)日：2005-07-20

申请号：EP03808704.5

申请日：2003-10-01

申请人： Epigenomics AG

发明人： FOEKENS, John ,  HARBECK, Nadia ,  KÖNIG, Thomas ,  MAIER, Sabine ,  MARTENS, John ,  MODEL, Fabian ,  NIMMRICH, Inko ,  RUJAN, Tamas ,  SCHMITT, Armin ,  SCHMITT, Manfred ,  LOOK, Maxime, P. ,  MARX, Almuth ,  HÖFLER, Heinz

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.

公开(公告)号：EP1458893A2

公开(公告)日：2004-09-22

申请号：EP02798327.9

申请日：2002-12-10

申请人： Epigenomics AG

发明人： BURGER, Matthias ,  FIELD, John, K. ,  GENC, Bülent ,  LILOGLOU, Triantafillos ,  BECKER, Evelyne ,  MAIER, Sabine ,  NIMMRICH, Inko

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/16 ,  C12Q2531/113 ,  C12Q2523/125 ,  C12Q2521/331 ,  C12Q2565/627

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differen­tiation, diagnosis, treatment and/or monitoring of lung cell proliferative disorders, or the pre­disposition to lung cell proliferative disorders.

公开(公告)号：EP1451354A2

公开(公告)日：2004-09-01

申请号：EP02787817.2

申请日：2002-11-25

申请人： Epigenomics AG

发明人： BURGER, Matthias ,  CALDWELL, Charles ,  GENC, Bülent ,  BECKER, Evelyne ,  MAIER, Sabine ,  NIMMRICH, Inko

IPC分类号： C12Q1/68

CPC分类号： C12Q1/683 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2523/125 ,  C12Q2521/331 ,  C12Q2525/107

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of lymphoid cell proliferative disorders, or the predisposition to lymphoid cell proliferative disorders.

公开(公告)号：EP1692316A2

公开(公告)日：2006-08-23

申请号：EP04820431.7

申请日：2004-12-13

申请人： Epigenomics AG

发明人： FOEKENS, John ,  HARBECK, Nadia ,  KÖNIG, Thomas ,  MAIER, Sabine ,  MARTENS, John ,  MODEL, Fabian ,  NIMMRICH, Inko ,  SCHMITT, Manfred ,  LESCHE, Ralf ,  DIETRICH, Dimo ,  MÜLLER, Volkmar Department of Genecology, ,  KLUTH, Antje ,  SCHWOPE, Ina ,  HARTMANN, Oliver ,  ADORJAN, Peter ,  MARX, Almuth ,  HÖFLER, Heinz

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell prolif­erative disorder of the breast tissues, to endocrine treatment.

公开(公告)号：EP1478778A2

公开(公告)日：2004-11-24

申请号：EP03714760.0

申请日：2003-02-27

申请人： Epigenomics AG

发明人： ADORJAN, Peter ,  BURGER, Matthias ,  MAIER, Sabine ,  NIMMRICH, Inko ,  BECKER, Evelyne ,  LESCHE, Ralf ,  RUJAN, Tamas ,  SCHMITT, Armin

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/154 ,  Y10T436/143333

摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.

公开(公告)号：EP1399589A2

公开(公告)日：2004-03-24

申请号：EP02726213.8

申请日：2002-03-26

申请人： Epigenomics AG

发明人： ADJORAN, Peter ,  LESCHE, Ralf ,  BECKER, Evelyne ,  MAIER, Sabine ,  MODEL, Fabian ,  NIMMRICH, Inko

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y02A90/24 ,  Y02A90/26

摘要： The present invention provides methods and computer program products for epigenetic feature selection. The invention enables the selection of relevant epigenetic features prior to further data analysis. The invention is preferably used for interpretation of large scale DNA methylation analysis data.