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1.发明公开NOVEL OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES 有权NEUARTIGE BENZOXAZOLON-SUBSTITUIERTE ARYLAMIDE
公开(公告)号：EP2445889A1
公开(公告)日：2012-05-02
申请号：EP10729825.9
申请日：2010-06-15
发明人： DILLON, Michael, P. , CHEN, Li , FENG, Lichun , YANG, Minmin
IPC分类号： C07D233/32 , C07D263/20 , C07D401/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D473/00 , C07D207/27 , A61K31/497 , A61K31/423 , A61K31/421 , A61K31/506 , A61K31/501 , A61K31/402 , A61K31/4166
CPC分类号： A61K31/497 , C07D207/27 , C07D233/32 , C07D263/20 , C07D401/14 , C07D403/12 , C07D407/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D473/00
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and R
7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X
3 and/or a P2X
2/3 receptor antagonists and methods of making the compounds.摘要翻译： 式I：或其药学上可接受的盐，其中X，Y，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。
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公开(公告)号：EP2038264A1
公开(公告)日：2009-03-25
申请号：EP07730213.1
申请日：2007-06-18
发明人： CHEN, Li , FENG, Lichun , HAWLEY, Ronald Charles , YANG, Minmin
IPC分类号： C07D257/04 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/12 , C07D407/10 , C07D413/10 , C07D417/12 , C07D417/10 , C07D491/10 , C07D498/08 , A61K31/41 , A61K31/5377 , A61K31/382 , A61K31/541
CPC分类号： A61K31/41 , A61K31/4439 , A61K31/497 , A61K31/5377 , C07D241/12 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/10 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/08
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 and R 6 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds.
摘要翻译： 其中R 1是任选取代的四唑基，R 2是任选取代的苯基，任选取代的吡啶基或任选取代的噻吩基，并且R 3，R 4，R 5和R 6如本文所定义。 还提供了使用所述化合物治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的方法以及制备所述化合物的方法。
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3.发明公开BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME 审中-公开苯并咪唑衍生物，PROCESS所周之，它们作为FXR激动剂和含筹备PHARAMZEUTISCHE
公开(公告)号：EP2038259A1
公开(公告)日：2009-03-25
申请号：EP07765461.4
申请日：2007-06-18
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , GRETHER, Uwe , KUHN, Bernd , MARTIN, Rainer E. , NIESOR, Eric J. , PANDAY, Narendra , RICHTER, Hans , SCHULER, Franz , WAROT, Xavier Marie , WRIGHT, Matthew , YANG, Minmin
IPC分类号： C07D235/18 , C07D409/10 , C07D409/04 , C07D403/04 , C07D403/10 , A61K31/4184 , A61P3/00 , A61P25/00 , A61P35/00
CPC分类号： C07D235/18 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/06
摘要： The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
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公开(公告)号：EP2445889B1
公开(公告)日：2016-08-10
申请号：EP10729825.9
申请日：2010-06-15
发明人： DILLON, Michael, P. , CHEN, Li , FENG, Lichun , YANG, Minmin
IPC分类号： C07D233/32 , C07D263/20 , C07D401/14 , C07D403/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D473/00 , C07D207/27 , A61K31/497 , A61K31/423 , A61K31/421 , A61K31/506 , A61K31/501 , A61K31/402 , A61K31/4166
CPC分类号： A61K31/497 , C07D207/27 , C07D233/32 , C07D263/20 , C07D401/14 , C07D403/12 , C07D407/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D473/00
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公开(公告)号：EP2038264B1
公开(公告)日：2016-10-26
申请号：EP07730213.1
申请日：2007-06-18
IPC分类号： C07D241/12 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D471/04 , C07D405/12 , C07D407/10 , C07D413/10 , C07D417/10 , C07D417/12 , C07D491/10 , C07D491/107 , C07D498/08
CPC分类号： A61K31/41 , A61K31/4439 , A61K31/497 , A61K31/5377 , C07D241/12 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/10 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/08
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted tetrazolyl, R 2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R 3 , R 4 , R 5 and R 6 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist and methods of making the compounds.
摘要翻译： 式I化合物或其药学上可接受的盐，其中R 1为任选取代的四唑基，R 2为任选取代的苯基，任选取代的吡啶基或任选取代的噻吩基，R 3，R 4，R 5和R 6为 如本文所定义。 还提供了使用该化合物治疗由P2X 3和/或P2X 2/3受体拮抗剂介导的疾病的方法和制备该化合物的方法。
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