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公开(公告)号：EP2558464B1
公开(公告)日：2014-06-18
申请号：EP11715201.7
申请日：2011-04-12
发明人： ACKERMANN, Jean , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , SCHULZ-GASCH, Tanja , WERTHEIMER, Stanley
IPC分类号： C07D471/10 , A61K31/438 , A61P3/00
CPC分类号： C07D471/10
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公开(公告)号：EP2430023B1
公开(公告)日：2013-12-11
申请号：EP10718183.6
申请日：2010-05-10
发明人： ACKERMANN, Jean , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , SCHULZ-GASCH, Tanja , WERTHEIMER, Stanley
IPC分类号： C07D471/10 , A61K31/438 , A61P3/00
CPC分类号： C07D471/10
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公开(公告)号：EP1996563B1
公开(公告)日：2012-03-21
申请号：EP07726290.5
申请日：2007-02-02
发明人： ACKERMANN, Jean , BLEICHER, Konrad , CECCARELLI, Simona, M. , CHOMIENNE, Odile , MATTEI, Patrizio , OBST SANDER, Ulrike
IPC分类号： C07D241/42 , C07D263/56 , C07D265/14 , C07D265/36 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04 , C07D498/04 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61P3/00
CPC分类号： C07D265/36 , C07D241/42 , C07D263/56 , C07D265/14 , C07D267/14 , C07D279/16 , C07D413/12 , C07D417/12 , C07D491/04
摘要： The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPTl and can be used as medicaments.
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公开(公告)号：EP1725546A1
公开(公告)日：2006-11-29
申请号：EP05715587.1
申请日：2005-02-28
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , HIRTH, Georges , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , WRIGHT, Matthew, Blake
IPC分类号： C07D403/12 , A61K31/4155 , A61P9/00
CPC分类号： C07D403/12
摘要： This invention is concerned with compounds of the formula (I), wherein one of R6, R7 and R8 is (II), and R1 to R15 and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
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公开(公告)号：EP2603510A1
公开(公告)日：2013-06-19
申请号：EP11741230.4
申请日：2011-08-10
发明人： ACKERMANN, Jean , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , SCHULZ-GASCH, Tanja , WERTHEIMER, Stanley
IPC分类号： C07D471/10 , A61P3/10 , A61K31/438
CPC分类号： C07D471/10
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 and n are as described herein, compositions including the compounds and methods of using the compounds.摘要翻译： 本发明提供具有通式（I）的新化合物，其中R 1，R 2和n如本文所述，包括该化合物的组合物和使用该化合物的方法。 该化合物可用作激素敏感性脂肪酶（HSL）的抑制剂，用于治疗糖尿病，代谢综合征和肥胖症。
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公开(公告)号：EP2507239A1
公开(公告)日：2012-10-10
申请号：EP10782616.6
申请日：2010-11-26
发明人： ACKERMANN, Jean , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , SCHULZ-GASCH, Tanja , WERTHEIMER, Stanley
IPC分类号： C07D471/10 , A61K31/438 , A61P3/00 , A61P3/10
CPC分类号： C07D471/10
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein R1, R2, R3 and n have the significance given in claim 1.
摘要翻译： 式（I）化合物及其药学上可接受的盐可以以药物组合物的形式使用，其中R1，R2，R3和n具有权利要求1中给出的含义。
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7.发明公开PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS 有权哌啶和它们用于肥胖，糖尿病的治疗，动脉粥样硬化血脂异常
公开(公告)号：EP2480532A1
公开(公告)日：2012-08-01
申请号：EP10739338.1
申请日：2010-07-27
发明人： ACKERMANN, Jean , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , WERTHEIMER, Stanley
IPC分类号： C07D211/44 , C07D211/58 , C07D409/12 , A61K31/435 , A61K31/44 , A61K31/4436 , A61P3/00
CPC分类号： C07D211/44 , C07D211/58 , C07D409/12
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A
1 , A
2 , R
1 , R
2 , R
3 and R
4 have the significance given in claim 1.-
公开(公告)号：EP2430023A1
公开(公告)日：2012-03-21
申请号：EP10718183.6
申请日：2010-05-10
发明人： ACKERMANN, Jean , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , SCHULZ-GASCH, Tanja , WERTHEIMER, Stanley
IPC分类号： C07D471/10 , A61K31/438 , A61P3/00
CPC分类号： C07D471/10
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein n, m, A, R
1 and R
2 have the significance given in claim 1. The compounds are useful as HSL inhibitors for the treatment of diabetes dyslipidemia, atherosclerosis and obesity.-
9.发明授权
公开(公告)号：EP1781608B1
公开(公告)日：2009-10-21
申请号：EP05772210.0
申请日：2005-08-08
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus
IPC分类号： C07D209/08 , A61K31/405 , A61P3/10 , A61P3/06
CPC分类号： C07D209/08
摘要： This invention is concerned with compounds of the formula (I), wherein one of R6, R7, R8 and R9 is formula (II), and X, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
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公开(公告)号：EP1725546B1
公开(公告)日：2008-10-08
申请号：EP05715587.1
申请日：2005-02-28
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , HIRTH, Georges , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , WRIGHT, Matthew, Blake
IPC分类号： C07D403/12 , A61K31/4155 , A61P9/00
CPC分类号： C07D403/12
摘要： This invention is concerned with compounds of the formula (I), wherein one of R6, R7 and R8 is (II), and R1 to R15 and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译： 本发明涉及式（I）化合物，其中R 6，R 7和R 8中的一个是（II），并且R 1至R 15和n如说明书中所定义，且所有对映异构体和药学上可接受的盐和/或酯 它们。 本发明进一步涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。
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