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公开(公告)号：EP1919920B1
公开(公告)日：2011-05-18
申请号：EP06813425.3
申请日：2006-08-14
发明人： RAWSON, Thomas, E. , SAFINA, Brian , DOTSON, Jennafer , ALIAGAS-MARTIN, Ignacio , HALLADAY, Jason , LIANG, Jun , RUETH, Matthias , ZHU, Bing-Yan , BROOKFIELD, Frederick , PRIME, Michael , ZHANG, Birong , LI, Jun, M. , Zhou, Aihe
IPC分类号： C07D487/04 , C07D491/04 , A61K31/4155 , A61P35/00
CPC分类号： C07D487/04 , C07D491/04
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula: (I) wherein A, X, Y, Z, Ra, Rb, Rc, R1 , R2, R3 and m are defined herein.
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2.发明公开HUMAN FCRN-BINDING MODIFIED ANTIBODIES AND METHODS OF USE 审中-公开富士康VERFAHREN ZUR VERWENDUNG的MENSCHLICHE FCRN-BINDUNGSMODIFIZIERTEANTIKÖRPER
公开(公告)号：EP2992012A1
公开(公告)日：2016-03-09
申请号：EP14721806.9
申请日：2014-04-25
发明人： HARTMANN, Guido , REGULA, Joerg Thomas , RUETH, Matthias , SCHAEFER, Wolfgang , SCHLOTHAUER, Tilman
IPC分类号： C07K16/22 , C07K16/46 , A61K39/395 , A61P27/02 , C07K16/28
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/54 , C07K16/2863 , C07K16/468 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要： Herein is reported the use of an antibody comprising an Fc-region with abolished FcRn binding for the transport of a soluble receptor ligand from the eye over the blood-ocular-barrier into the blood circulation.
摘要翻译： 本文报道了使用包含具有消除的FcRn结合的Fc区的抗体，以将可溶性受体配体从眼睛转移到血液屏障进入血液循环。
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3.发明公开TRICYCLIC AZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 有权三环唑酮衍生物及其制造和用作药物的用途
公开(公告)号：EP1885725A1
公开(公告)日：2008-02-13
申请号：EP06707595.2
申请日：2006-03-17
发明人： GEORGES, Guy , GOLLER, Bernhard , KRELL, Hans-Willi , LIMBERG, Anja , REIFF, Ulrike , RUEGER, Petra , RUETH, Matthias
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00 , A61P43/00 , C07D209/00 , C07D235/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述 化合物用于控制或预防诸如癌症的疾病。
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4.发明公开
公开(公告)号：EP1879894A1
公开(公告)日：2008-01-23
申请号：EP06707596.0
申请日：2006-03-17
发明人： GEORGES, Guy , GOLLER, Bernhard , KUENKELE, Klaus-Peter , LEMARCHAND, Aude , LIMBERG, Anja , REIFF, Ulrike , RUEGER, Petra , RUETH, Matthias
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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5.发明公开
公开(公告)号：EP1758897A1
公开(公告)日：2007-03-07
申请号：EP05779891.0
申请日：2005-03-31
IPC分类号： C07D413/14 , A61K31/422
CPC分类号： C07D413/14
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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6.发明公开FCRN-BINDING ABOLISHED ANTI-IGF-1R ANTIBODIES AND THEIR USE IN THE TREATMENT OF VASCULAR EYE DISEASES 有权FcRn的BINDUNGSVERHINDERNDE抗IGF-1R抗体及它们在血管疾病眼部治疗
公开(公告)号：EP2992011A1
公开(公告)日：2016-03-09
申请号：EP14721295.5
申请日：2014-04-25
发明人： HARTMANN, Guido , REGULA, Joerg Thomas , RUETH, Matthias , SCHAEFER, Wolfgang , SCHLOTHAUER, Tilman
CPC分类号： A61K39/3955 , A61K9/0048 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The invention provides anti-IGF-1R antibodies with abolished FcRn-binding and methods of using the same for the treatment of vascular eye diseases.
摘要翻译： 本发明提供了消除FcRn结合并使用相同的血管眼疾病的治疗方法的抗IGF-1R抗体。
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7.发明公开INCRETIN RECEPTOR LIGAND POLYPEPTIDE FC-REGION FUSION POLYPEPTIDES AND CONJUGATES WITH ALTERED FC-EFFECTOR FUNCTION 审中-公开融合多肽并与经修饰的Fc效应与Fc区INKRETINREZEPTOR-LIGANDPOLYPEPTIDEN的结合物
公开(公告)号：EP2863954A1
公开(公告)日：2015-04-29
申请号：EP13736683.7
申请日：2013-06-18
发明人： DIMARCHI, Richard D. , HOFFMANN, Eike , KOPETZKI, Erhard , RUETH, Matthias , TIEFENTHALER, Georg
IPC分类号： A61K47/48
CPC分类号： C07K16/46 , A61K47/68 , A61K47/6811 , C07K2317/71 , C07K2319/30
摘要： Herein is reported an Fc-region fusion polypeptide or Fc-region conjugate comprising one to four incretin receptor ligand polypeptides and a variant human Fc-region with a mutation of the amino acid residue at position 329 and at least one further mutation of at least one amino acid selected from the group comprising amino acid residues at position 228, 233, 234, 235, 236, 237, 297, 318, 320, 322 and 331 to a different residue, wherein the residues in the Fc-region are numbered according to the EU index of Kabat and its use as a medicament.
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8.发明公开TRICYCLIC LACTAM DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开三环内酰胺衍生物，制备方法及其作为药剂
公开(公告)号：EP1966213A1
公开(公告)日：2008-09-10
申请号：EP06829573.2
申请日：2006-12-13
发明人： GEORGES, Guy , GOLLER, Bernhard , KRELL, Hans-Willi , LIMBERG, Anja , REIFF, Ulrike , RUEGER, Petra , RUETH, Matthias , SCHUELL, Christine , STAHL, Mark
IPC分类号： C07D487/04 , A61K31/4164 , A61P35/00
CPC分类号： C07D487/04
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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公开(公告)号：EP1794148A1
公开(公告)日：2007-06-13
申请号：EP05785230.3
申请日：2005-09-23
发明人： BOYD, Edward , BROOKFIELD, Frederick , GEORGES, Guy , GOLLER, Bernhard , HUENSCH, Sabine , RUEGER, Petra , RUETH, Matthias , SCHEIBLICH, Stefan , SCHUELL, Christine , VON DER SAAL, Wolfgang , WARNE, Justin , WEIGAND, Stefan
IPC分类号： C07D403/12 , A61P35/00 , A61K31/502
CPC分类号： C07D403/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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公开(公告)号：EP1794148B1
公开(公告)日：2009-04-15
申请号：EP05785230.3
申请日：2005-09-23
发明人： BOYD, Edward , BROOKFIELD, Frederick , GEORGES, Guy , GOLLER, Bernhard , HUENSCH, Sabine , RUEGER, Petra , RUETH, Matthias , SCHEIBLICH, Stefan , SCHUELL, Christine , VON DER SAAL, Wolfgang , WARNE, Justin , WEIGAND, Stefan
IPC分类号： C07D403/12 , A61P35/00 , A61K31/502
CPC分类号： C07D403/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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